Department of Pathology

  

Clinical Pathology Case of the Month

In July 1995, the Department of Pathology began highlighting a new clinical pathology case every month, to be called the Case of the Month. Normally, these are cases of greater than normal clinical interest, cases with unusual symptoms and/or diagnostic findings, or cases involving rare diseases or conditions. Below is a link to the current Clinical Pathology Case of the Month. Also listed below are previous cases which have been highlighted as Case of the Month.

Disclaimer: Review of the Case of the Month is intended for educational purposes ONLY, NOT for research.

Previous Cases

• December 2022:  An Elderly Man with Acute Thrombocytopenia Requiring Cardiac Transplantation
• November 2022:  Acute Kidney Injury and Rhabdomyolysis
• October 2022:  Evaluation of a suspected seizure
• September 2022:  A Young Woman with Easy Bruising (CP-0922, Secure Access)
  
• May 2022:  A Woman in Her Late 80s with Anemia (CP-0522)
  
• April 2022:  A Patient with a Medial Thigh "Lump" Thought to Be a Hematoma (CP-0322)
  
• March 2022:  A Male in His 50s with a Renal Mass (CP-0322)
  
• February 2022:  A Young Woman with Abdominal Pain (CP-0222)
  
• January 2022:  Isolated elevated Gamma Glutamyl Transferase (GGT) Concentrations (CP-0122)
• December 2021:  A Man in his Late 60s with Low Appetite and Weight Loss (CP-1221)
  
• November 2021:  Germline GATA2 Mutation in Myelodysplasia-related Acute Myeloid Leukemia (CP-1121)
  
• October 2021:  An Adult Male with Right-sided Weakness and Aphasia (CP-1021)
  
• September 2021:  A Newborn with Severe Hypoglycemia and Hypothermia (CP-0921)
  
• June 2021:  Adult Male with an Unusual Follicular Lymphoma Transformation (CP-0621)
  
• May 2021:  A Post-transplant Elderly Man with Abdominal Pain (CP-0521)
  
• April 2021:  A Female Child with 21q Deletion (CP-0421)
  
• Feburary 2021:  An Adult Male with Restricted Peripheral Vision and Nystagmus (CP-0221)
  
• February 2021:  An Elderly Man with Lung Adenocarcinoma (CP-0221)
  
• January 2021:  Kidd Alloimmunization During Pregnancy
  
• December, 2020:  An Infant with Failure to Thrive and Developmental Regression
  
• November 2020:  Necrotizing Lymphadenitis in a Young Toddler Boy
  
• October 2020:  A Patient with Altered Mental Status
  
• March 2020:  Anti-Microbial Refractory Fungal Infection in a Patient with Severe Neutropenia
  
• February 2020:  A Male Undergoing Therapeutic Drug Monitoring for Busulfan Dosing
  
• January 2020:  The KMT2A Partial Tandem Duplication: Recurrent Cryptic Alteration in AML with Normal Karyotype
  
• December, 2019:  A Female with Chief Complaints of Fever, Productive Cough, Night Sweats and Weight Loss
  
• November, 2019:  A Female Infant with Fever and Pancytopenia
  
• October, 2019:  An Elderly Male with Respiratory Distress Following Transfusion
  
• September, 2019:  Severe Acidosis in an Adult Female
  
• April 2019:  A Young Adult Male with Early Satiety and Leukocytosis of 50 x 10⁹/L
  
• February 2019:  Molecular Testing of a Metastatic Subcutaneous Lesion
  
• December, 2018:  A Female in Her 60's with Diplopia
  
• November, 2018:  A Male Toddler with Developmental Delays and Behavioral Issues
  
• October, 2018:  A Male with Recent Traumatic Splenectomy
  
• September, 2018:  An Elderly Female with Anemia
  
• May 2018:  A Bioterror Agent in the Laboratory
  
• April 2018:  An Elderly Man with an Unusual Peripheral Blood Smear
• March 2018:  Undetectable Luteinizing Hormone Levels in a Precocious Puberty Evaluation
  
• February 2018:  Thyroid, or Not Thyroid -- That Is the Question
  
• January 2018:  Molecular Testing of a Thyroid Nodule in an Elderly Woman
• December 2017:  Monoclonal IgG/kappa in a Woman in Her 80s
  
• November 2017:  A Male Newborn with Bruising and Petechia
  
• October, 2017:  A 2-week Old Neonate with Refractory Thrombocytopenia Not Responding to Random Donor Platelets
  
• September, 2017:  A Premature Infant with Persistent Anemia
  
• May 2017:  Excessively High Acylcarnitine Values in the New Born Screen of Premature Infant
  
• April 2017:  A Pediatric Male with Acute Myeloid Leukemia (AML) and Severe Neutropenia
• March 2017:  A Male Teenager with Complaint of Weakness, Nausea, and Vomiting(Restricted Access)
  
• February 2017:  A 3-year-old Boy with Asperger's Syndrome (Restricted Access, CP-0217)
  
• January 2017 Genomic Analysis of a Renal Mass in a Toddler
• December 2016:  A Woman in Her Late 30's with a History of Recurrent Scalp Lesion
  
• November 2016:  A Young Boy with Liver Transplantation
  
• October 2016:  A Young Child with Short Stature, Hypoplastic Thumb and Pancytopenia
  
• September 2016:  A Gentleman with a Lump in his Jaw
  
• March 2016:  A Female in Her Early 60s with Worsened Joint Pain after Initiation of Immunotherapy
  
• January 2016:  A Male in His 20s with Hematuria, Hypertension, Seizure and Aplastic Anemia (Restricted Access, CP-0116)
  
• November 2015:  A case of unexplained cerebral sinus thrombosis
  
• September 2015:  A 53-year-old male with leukocytosis and a neutrophilic left shift
  
• July 2015:  A 31 year old male with aggressive behavior and fever
  
• June 2015:  A 30-year-old woman with intermittent joint pain in her wrists and ankles
  
• May 2015:  A woman in her 30s with urticaria, flushing, and cramping abdominal pain
  
• April 2015:  A 76-year old female with nephrotic range proteinuria and urine albumin to protein ratio less than 10%
  
• January 2015:  A man with chronic liver disease and headaches
  
• December 2014:  A 52 year-old male with angiokeratomas, anhydrosis, and acral paresthesias (Restricted Access)
  
• November 2014:  A 30 year old male with a right corneal abrasion
  
• October 2014:  A 24 year-old female in labor at 38 weeks with a positive HIV screen
  
• June 2014:  A 55-year-old man with hemoglobin of 6.5 g/dL
  
• May 2014:  A 66-year-old female with complaint of weakness
  
• April 2014:  A 56 year-old Female with a Serum hCG of 5 mIU/ml
  
• March 2014:  A 64 year old male with a lung nodule
  
• February 2014:  A five-day old female with an abnormal newborn screen
  
• January 2014:  A 48 year old male with hip pain, confusion, headaches and blurry vision
  
• December 2013:  A 22 year old male with chronic cough and weight loss
  
• November 2013:  An eighteen month boy with parental complaints of fussiness and pallor
  
• October 2013:  A 66 year old female with excessive fatigue
  
• September 2013:  AA 55-year-old male presents to the ED
  
• July 2013   An 82 year old female with thrombocytopenia
• June 2013:  A 63-year-old woman with a thyroid nodule
• May 2013:  A 66 year old male with back pain and hemoptysis
• April 2013:  A 21-year-old female with a bladder mass
• March 2013:  A 49 year old female with nausea and vomiting
  
• February 2013:  A 79 year-old female with abdominal pain and bloody urine after dialysis session
  
• January 2013:  A 25 year old female with complaints of a severe headache and agitation
  
• December 2012:  An 81 year-old woman with complaint of weakness
  
• November 2012:  A 2.5 months old female with neurologic symptoms
  
• October 2012:  A 3 year old male with fatigue and hepatomegaly
  
• September 2012:  A 75 year-old man with back pain
  
• Auguest 2012:  A 53 year old male with intermittent fevers, night sweats, and a chronic cough
• June 2012:  Elevated troponin in a 41 year old male with ST elevations
• April 2012:  A 22 year old female with weight gain, fatigue, facial swelling, increased thirst, and increased frequency of urination, pneumonia, and leukocytosis
• March 2012:  A 61 year old male with pneumonia and leukocytosis
  
• February 2012:  Genetic Testing in Hirschsprung Disease
  
• January 2011:  A 20 year old male with persistent cough
  
• December 2011:  A 46 year old female with shortness of breath
  
• November 2011:  A 4-month-old boy with new onset seizures
  
• October 2011:  A 49 year old male with tooth pain
  
• September 2011:  Two patients with red urine
  
• August 2011
  Case 1
  Case 2
  
• July 2011:  An 80-year old male with peripheral blood lymphocytosis
  
• June 2011
  Case 1
  Case 2
  Case 3
  
• May 2011:  A 57-year-old male with chronic hepatitis C and IL28B CT genotype
  
• April 2011:  A 46 year old female with inconsistent thyroglobulin concentrations
  
• March 2011:  A 42-year-old male with sudden onset of suprapubic and pelvic discomfort
  
• February 2011:  A 54-year-old woman with recent onset of pancytopenia of unknown etiology
  
• January 2011:  A 61 year old female with a recent venous thrombosis and a wild-type MTHFR 677 genotype
  
• December 2010:  A 57 year old man with a systemic disease and an intracerebral hemorrhage
  
• November 2010:  A 63 year-old male with confusion and fluent aphasia
  
• October 2010:  A 62 year old woman with a family history of a neurodegenerative disorder
  
• September 2010:  A 30-year old man with a 30-pound weight loss in one month
  
• August 2010:  A 37 year-old woman with a “mole” on her calf
  
• July 2010:  An 86 year-old female with a history of hematolymphoid neoplasia (Purged)
  
• June 2010:  A 7 week old male with ambiguous genitalia and history of Hirschprung disease
  
• May 2010:  A 67-year old man with high fever, fatigue and weight loss
  
• April 2010:  Vaginal culture of a pregnant woman
  
• March 2010:  A young man with influenza
  
• February 2010:  Antibodies to dsDNA
  
• February 2010:  Recurrent pneumonia and pain crises in a young female patient
  
• December 2009:  A 7-year-old boy with polyuria, polydipsia, and enuresis
  
• November 2009:  A fifty-year-old male with muscle weakness and hypokalemia
  
• October 2009:  An eight-year-old boy with staring episodes
  
• September 2009:  A 33 year old, pregnant female with neutrophilia
  
• August 2009:  A 21 year-old male with severe headaches
  
• July 2009:  A 61 year-old female with abdominal pain and leukocytosis (Purged)
  
• June 2009:  A 38-year-old female with recurrent miscarriages
  
• May 2009:  A 54 year-old female with fever and chills
  
• April 2009:  A 13 year-old girl with short stature
  
• March 2009:  A 19-year-old male with febrile illness, respiratory failure, and hepatosplenomegaly
  
• February 2009:  A 57 year old male with hepatitis C infection, lymphoma and renal disease
  
• January 2009:  A 25 year-old male with high fever
  
• December 2008:  Urinary bicarbonaturia in a 27 year old male
  
• November 2008:  A 77 year-old male with diarrhea
  
• October 2008:  A 76 year old transplant patient with fever
  
• September 2008:  A patient with fatal respiratory distress immediately after transplant surgery
  
• August 2008:
      Case 1 A 74-year-old man with anemia
      Case 2 A 21-year old male with history of intravenous drug abuse
  
• June 2008:  Persistent hand arthralgias and swelling in an otherwise healthy 45 y/o male
  
• May 2008:
      Case 1 A 50-year old Caucasian female with a pituitary mass
      case 2 A 19-year-old female with fever, rash and lymphadenopathy for one month
  
• April 2008:  A 61-year-old female with abdominal discomfort and jaundice
  
• March 2008:  A 53-year-old male found convulsing in a cemetery
  
• February 2008:  A 17 year-old girl with Raynaud's phenomenon
  
• January 2008:  A 54 year-old male with one episode of vomiting, cognitive alteration, and left leg weakness
  
• December 2007:  An 11-year-old girl with symptoms of hyperthyroidism
  
• November 2007:  A 36 year-old kidney transplant recipient with increased creatinine
  
• October 2007:  Sinusitis in a 20-year-old Male with Aplastic Anemia
  
• September 2007:  A 23 year-old man with left knee pain
  
• August 2007:  A 10 year old female with pruritic lacy rash
  
• July 2007:  An 82-year-old man with moderate thrombocytopenia
  
• June 2007:  A 62 year-old male with pain in the right clavicular region
  
• May 2007:  Differentiating Transfusion Associated Circulatory Overload from Transfusion-Related Acute Lung Injury
  
• April 2007:  Small colony variant-Staphylococcus aureus
  
• March 2007:  Two young patients with abdominal pain
  
• February 2007:
      Case 1 A 9-year-old girl with recurrent bilateral ovarian masses
      Case 2 A 4-year-old girl with fever and pain in the lower extremities
  
• January 2007:  5-month-old twins with turricephaly
  
• December 2006:   A 3-month-old girl with hypotonia
• November 2006:  A 10-year-old male with decreased complement
• October 2006:  An one year-old boy with delayed speech
• September 2006:  A 7 year old boy with massive splenomegaly
  
• August 2006:  A 25 Year-Old Male with Fever
  
• July 2006:  A 2-year-old boy with hypotonia and developmental delay
  
• June 2006:  A 56-year-old female with anemia and leukocytosis
  
• May 2006:  A 36 year-old man with abdominal pain
  
• April 2006:  A 74-year-old male with mycosis fungoides now with increased circulating immature mononuclear cells
  
• March 2006: 
  Case A and Case B
  
• February 2006:  A 68-year-old man with upper gastrointestinal bleeding
  
• January 2006:  A newborn with trisomy 21 and elevated level of C5-hydroxy acylcarnitine
  
• December 2005:  Transfusion-Refractory Anemia: Immune Or Non-Immune Hemolysis?
  
• November 2005:  A 61-year-old woman with chronic lymphocytic leukemia, pancytopenia and abdominal pain
  
• October 2005:  A woman in her 80s with bowel obstruction
  
• September 2005:  A One-year-old child with Megakaryoblastic Leukemia (Purged)
  
• August 2005:  A 10 month-old girl with hypotonia
  
• July 2005:  Ghost mycobacteria on Gram stain
  
• June 2005:  A 32 year old man with severe pancytopenia
  
• May 2005:  A 57-year-old male with persistent leukocytosis
  
• April 2005:  A 15-year-old male with progressive loss of central vision and macular edema
  
• March 2005:  A pregnant woman in early 40s with thrombocytopenia
  
• February 2005:  A lung transplant patient with nausea, vomiting and dehydration
  
• January 2005:  A 12 year-old boy presented with substernal chest pain
  
• December 2004:  A man in his 80s with multiple cutaneous nodules
  
• November 2004:  A 49-year-old white woman found dead in her bed
  
• October 2004:  Esophageal perforation with an unusual etiology
  
• September 2004:  Anemia and thrombocytopenian in a newborn
  
• August 2004:  A woman in her 40s with left flank pain and symptoms of ureteral obstruction
  
• July 2004:  A middle-aged man with intractable lower back pain
  
• June 2004:  A female in her 20s with pharyngitis, odynophagia, dysphagia
  
• May 2004:  A man in his 70's who has monoclonal gammopathy of undetermined significance, or does he?
  
• April 2004:  A man in his 50s with fever, headache, and sore throat
  
• March 2004:  A baby boy with failure to thrive and respiratory insufficiency
  
• February 2004:  An unusual pelvic mass in a female in her 60s
  
• January 2004:  A male in his 30s scheduled for Liver transplant
  
• December 2003:  A male in his 50s with chronic anemia
  
• November 2003:  A female in her 20s with Refsum's disease
  
• October 2003:  A female in her 40s with repeated episodes of flushing, headache, shortness of breath, tachycardia and hypotension
  
• September 2003:  Myelodysplastic syndrome and bone marrow transplant engraftment failure
  
• August 2003:  A male in his 40s with severely compromised vision
  
• July 2003:  A female in her 40s with severe transfusion reaction (Purged)
  
• June 2003:  A teenager girl with severe behavioral problems
  
• May 2003:  A man in his 40s with severe headaches after a fall
  
• April 2003:  A young boy with microcephaly and developmental delay
  
• March 2003:  A female her 30s with sinus pressure, headache and gingival hyperplasia (Purged)
  
• February 2003:  Familial adenomatous polyposis: A molecular diagnostic approach
  
• January 2003:  A 15-year-old male with elevated ammonia levels
  
• December 2002:  A 58-year-old male with parasites in his blood
  
• November 2002:  A 38 year-old female with elevated tricyclic antidepressant levels
  
• October 2002:  A 2-year-old boy with prolonged oral bleeding
  
• September 2002:  Rheumatoid arthritis and peripheral leukocytosis
  
• August 2002:  Two weeks in Africa
  
• July 2002:  A 60-year-old male with fever, chills, and shortness of breath
  
• June 2002:  A 14-year old female with emesis and cyanosis
  
• May 2002:  A 56-year old male with dog bites
  
• April 2002:  A 56 year old female with post transfusion hemolysis
  
• March 2002:  A 78-year-old male presented with a history of cervical adenopathy
  
• February 2002:  A 79-year old male with right neck mass
  
• January 2002:  A 55 year old male with drop in hemoglobin following platelet transfusion
  
• December 2001:  A 40 year old man with a enlarged right axillary lymph node
  
• November 2001:  A 56 year old female with one lymph node metastasis and two oral squamous cell tumors
  
• October 2001:  An 83-year-old with post-operative bleeding
  
• September 2001:  Transfusion therapy in a 60-year-old with immunoglobulin deficiency
  
• August 2001:  A 75-year-old woman with duodenal submucosal mass and anemia
  
• July 2001:  A 69 year-old female with bloody urine following transfusion
  
• June 2001:  A 58 year old female with chronic myeloid leukemia
  
• May 2001:  A girl in coma
  
• April 2001:  A 77-year-old with acute onset of epistaxis
  
• March 2001:  A 42-year-old African male with diarrhea and urinary frequency
  
• February 2001:  A 72 year-old male with lymphocytosis (Purged)
  
• January 2001:  A 16 year old female with left Inguinal and bilateral breast masses
  
• December 2000:  A newborn with petechiae
  
• November 2000:  A 3 year-old female with anemia and thrombocytopenia
  
• October 2000:  A 4 year old girl with chronic otitis media
  
• September 2000:  A 68 years old white female with worsening anemia, thrombocytopenia, renal insufficiency
  
• August 2000:  A 51 year old male with fatigue, easy bruising and cellulitis (Purged)
  
• July 2000:  A 30 year old plumber with a flank mass for several months
  
• June 2000:  A 41 year old male with swelling and ulceration of the uvula and soft palate
  
• May 2000:  A 47 year old woman with increased thirst, lethargy and a body weight gain
  
• April 2000:  A 75 year old female with bilateral pneumonia
  
• March 2000:  A 21 year old male with a cystic tumor in his right thigh
  
• February 2000:  A 46-year-old HIV-positive man with a destructive palate lesion
  
• January 2000:  A 40 year old white female with left internal carotid artery thrombosis
  
• December 1999:  A 36 years old male with left internal carotid artery thrombosis
  
• November 1999:  A 39 year-old female with a cavitary lesion in the right upper lung lobe
  
• October 1999:  A 62-year-old male with fatigue and malaise
  
• September 1999:  A 67-year-old male with intermittent confusion, fever of unknown origin, and lower extremity weakness
  
• August 1999:  Cervical lymphadenopathy in a young female
  
• July 1999:  A 78 year old man with rectal mass
  
• June 1999:  A 47 year old man with monoclonal protein in his serum
  
• May 1999:  A 68 year-old female with extremely labored breathing
  
• April 1999:  An eighty-one year old woman with an axillary mass
  
• March 1999:  A 75-year-old male with oligoarthritis and localized swellings
  
• February 1999:  A 68-year-old woman witha history of bilateral back pain and fever
  
• January 1999:  Profiles of total CK, CK-MB and troponin I in two cases of acute myocardial infarction
  
• December 1998:  A 79 year old white male with pain, swelling and decreased function of left knee
  
• Novembr 1998:  A 39 year old woman with fatigue and weight loss
  
• October 1998:  A 24 year-old female with transfusion reaction
  
• September 1998:  A 66 year old man with macrocytic anemia (Purged)
  
• August 1998:  A 29 year old man with anosmia and decreased vision in the right eye
  
• July 1998:  A 74 year old man with sepsis
  
• June 1998:  A 25 year old women with renal failure, anemia and thrombocytopenia
  
• May 1998:  A 68 year old man with fevers
  
• April 1998:  A 74-year-old male with a history of chronic lymphocytic leukemia (CLL) and malignant melanoma (Purged)
  
• March 1998:  A 76 year old white male with dyspnea and leukocytosis (Purged)
  
• February 1998:  A 22 year old male with postoperative abdominal discomfort
  
• January 1998:  A 68 year old man with an anterior mediastinal mass
  
• December 1997:  A 36 year old female with multiple myxomas and thyroid cancer
  
• November 1997:  A 37 year old man with fever and a hilar pulmonary mass
  
• October 1997:  Lash's Bitters: biochemical analysis of a historical proprietary medicine
  
• September 1997:  A neonate with intracranial hemorrhage and seizure activity
  
• August 1997:  A 20 year old woman with anemia and abdominal pain
  
• July 1997:  A fifty-eight year old female with dizziness and headache
  
• June 1997:  Transfusion reaction in a fifty-eight year old man
  
• May 1997:  A 3 1/2 month old child with anemia, neutropenia, and lactic acidosis
  
• April 1997:  Sixty seven year old woman with abnormal preoperative RBC type and crossmatch testing
  
• March 1997:  A thirty-three year old male with a permanent intravascular catheter
  
• February 1997:  Twenty-six year old female with peritonitis
  
• January 1997:  Three week old baby girl with loss of body weight, facial and skeletal anormalies
  
• December 1996:  Twenty-two year old male with acute leukemia, nodular skin lesion, and splenomegaly
  
• November 1996:  Two month old boy with symptoms and signs of insecticite poisoning
  
• October 1996:  Fifty-two year old woman with skin and soft tissue infection of the left foot
  
• September 1996:  Three-week old infant with hemangioma and severe thrombocytopenia
  
• August 1996:  Sixty-five year old male with abdominal pain
  
• July 1996:  Twenty-nine year old female with Systemic Lupus Erythematosis
  
• June 1996:  Twenty-nine year old female with fever and hemoptysis
  
• May 1996:  Fever and severe rigors during transfusion in a 55-year-old woman
  
• April 1996:  White Matter Lesions
  
• March 1996:  Severe Headache and Fever
  
• February 1996:  Sore Throat and Leukocytosis (Purged)
  
• January 1996:  Fever, Purpura, and Hypotension
  
• December 1995:  Mesenteric Adenopathy
  
• November 1995:  Confusion, Agitation and Unresponsiveness
  
• October 1995:  Intermittent Fevers
  
• September 1995:  Anemia
  
• August 1995:  Lymphadenopathy
  
• July 1995:  Hypercalcemia

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