Contributed by Laura Favazza, DO and Arivarasan Karunamurthy, MD, Department of Pathology, University of Pittsburgh Medical Center
This is a female in her late 40s with a history of uveal melanoma in her left eye status post plaque radiation, four years ago. She now presents with multiple subcutaneous lesions, as well as lung and liver lesions. A subcutaneous lesion on the back was biopsied.
SURGICAL PATHOLOGY REPORT
SOFT TISSUE, RIGHT BACK, EXCISION: METASTATIC MELANOMA, CONSISTENT WITH A UVEAL PRIMARY, INVOLVING FIBROADIPOSE TISSUE (see comment).
COMMENT: Per the patient's electronic medical record, a history of a widely metastatic uveal melanoma is noted. The biopsy specimen consists of a pigmented spindle cell neoplasm. An immunohistochemical stain for Sox10 is positive within the neoplastic cells; while, BAP1 shows loss of nuclear expression. Based on the histologic findings and immunoprofile, the neoplasm is consistent with a metastatic melanoma from the patient's known uveal primary.
Oncomine testing is performed.