Roderick J. Tan, MD, PhD
Assistant Professor of Medicine.

Dr. Tan is an Assistant Professor of medicine.

Office Location:
828A Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-624-4008
Lab Telephone: 412-648-9399

Research Interests

Dr. Tan is interested in unraveling the molecular mechanisms underlying the development of acute kidney injury and chronic kidney disease and fibrosis utilizing both in vivo and in vitro approaches. In particular, he is assessing novel ways in which the glomerular and tubular compartment cross-talk in disease, and how the Nrf2/Keap1 pathway can be leveraged to prevent CKD. He is also studying how the Wnt/beta-catenin pathway and matrix metalloproteinases affect renal injury.

Selected Publications

  1. Rush BM, Small SA, Stolz DB, Tan RJ. An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney. J Vis Exp. 2018 Nov 1;(141). doi: 10.3791/58162. PubMed PMID: 30451231; PubMed Central PMCID: PMC6688477.
  2. Jobbagy S, Tan RJ. Nitrolipids in kidney physiology and disease. Nitric Oxide. 2018 Mar 29;. doi: 10.1016/j.niox.2018.03.021. [Epub ahead of print] Review. PubMed PMID: 29605557; PubMed Central PMCID: PMC6163094.
  3. Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep. 2016 Nov 2;6:36185. doi: 10.1038/srep36185. PubMed PMID: 27804998; PubMed Central PMCID: PMC5090361.
  4. Tan RJ, Zhou D, Liu Y. Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury.Kidney Dis (Basel). 2016 Oct;2(3):136-144. doi: 10.1159/000446336. Epub 2016 May 21. Review. PubMed PMID: 27921041; PubMed Central PMCID: PMC5123005.
  5. Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol. 2015 Oct;26(10):2447-59. doi: 10.1681/ASN.2014060613. Epub 2015 Feb 2. PubMed PMID: 25644107; PubMed Central PMCID: PMC4587687.
  6. Tan RJ, Zhou L, Zhou D, Lin L, Liu Y. Endothelin receptor a blockade is an ineffective treatment for adriamycin nephropathy. PLoS One. 2013;8(11):e79963. doi: 10.1371/journal.pone.0079963. eCollection 2013. PubMed PMID: 24265790; PubMed Central PMCID: PMC3825716.