Steven H. Swerdlow, MD
Professor of Pathology


Dr. Swerdlow is the director of the Division of Hematopathology. He oversees a nine member division of hematopathology that has a broad range of investigative, educational and clinical service responsibilities. As the only specialized hematopathology resource in the UPMC Health System, he oversees activities and labortories that benefit the numerous UPMC facilities. He also personally participates in all these activities and serves as an internationally known hematopathologist promoting our department in varied venues in the U.S. and around the world.

Office Location:
Hill Building, 3rd Floor, Room 359
3477 Euler Way
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-578-9423
Fax: 412-647-4008
Email: swerdlowsh@upmc.edu

Education

  • MD - Harvard Medical School, 1975
  • AB - summa cum laude, with honors in Biology, 1971

Certifications

National Board of Medical Examiners, 1976

American Board of Pathology:

  • Anatomic & Clinical Pathology, 1979
  • Recertification, 2013 (2013-2023)
  • Continuing of Certification Participant, 2012-Present

Specialties

Hematopathology

Awards and Honors

  • Listed in America's Top Doctors (US News & World Report top 1% in specialty), 2001-2021
  • Outstanding Teaching in Clinical Pathology Resident Award, 1994, 2001, 2009
  • Trustee and Immediate Past-President, American Board of Pathology
  • Listed in Best Doctor in Pittsburgh, Pittsburgh Magazine, 2013- 2021
  • Berard-Dorsman founders Award (Society for Hematopathology), 2015
  • The Harvey Goldman Master Teacher of the Year Award, United States and Canadian Academy Pathology, 2017
  • Elected Member, International Lymphoma Study Group

Clinical Expertise

Dr. Swerdlow's expertise is in hematopathology with an emphasis on lymph node and related tissue diagnostic hematopathology using a multiparameter approach that incorporates morphology, flow cytometric and immunohistochemical phenotype, cytogenetic, molecular, and clinical data. He is also responsible for oversight of the Division's varied clinical activities that include general hematology laboratories, a flow cytometry laboratory, and a variety of diagnostic services.

Research Interests

Some current areas of investigation include multiparameter investigations of select cutaneous B-Cell lymphomas, high grade B-cell lymphomas including the "double hit" lymphomas and B-lymphoblastic neoplasms, and varied subsets of small B-cell lymphomas. More recently he also been involved with issues related to pathology education and assesment at the postgraduate level. He remains actively involved in developing and reviewing the classification of lymphoma.

Selected Publications

View Dr. Swerdlow's publications on PubMed

Peer-Reviewed Articles

  • Chen, B.J., Ruminy, P., Roth, C.G., Bisig, B., Mankel, B., Steinhilber, J., Bohers, E., Jardin, F., Fend, F., Swerdlow, S.H., Copie-Bergman, C., de Leval, L., Quintanilla-Martinexz, L., "Cyclin D1-positive Mediastinal Large B-Cell Lymphoma with Copy Number Gains of CCND1 Gene: A Study of 3 Cases with Nonmediasinal Disease". Am J Surg Pathol. 2019, 43 (1):110-120
  • Martìn-Garcia, D., Navarro, A., Valdés-Mas, R., Clot, G., Gutiérrez-Abril, Prieto, M., J., Ribera-Cortada, I., Woroniecka, R., Rymkiewicz, G., Bens, S., de Leval, L., Rosenwald, A., Ferry, J.A., Hsi, E.D., Fu, K., Delabie, J., Weisenburger, D., de Jong, D., Climent, F., O'Connor, B.J., Swerdlow, S.H., Torrents, D., Beltran, S., Espinet, B., Gonzàlez-Farré, B., Veloza, L., Costa, D.,Matutes, E., Siebert, R., Ott, G., Quintanilla-Martinez, L, Jaffe, E.S., López-Otín, C., Salaverria, I., Puente, X.S., Campo, E., Beà, S., "Immunoglobulin light chain enhancer hijacking activates CCND2 and CCND3 in cyclin D1-negative mantle cell lymphoma" Blood, 2019,133 (9): 940-951
  • Selove, W., Picarsic, J., Swerdlow, S.H., "Langerin Staining identifies most littoral cell angiomas but not most over splenic angiomatous lesions". Hum Pathol., 2019, 83: 42-49
  • Willemze, R., Cerroni, L., Kempf, W., Berti, E., Facchetti, F., Swerdlow, S.H., Jaffe, E.S., "The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas" Blood. 2019 18:133(16):1703-1714.
  • Lontos, K., Tsagianni, A., Yuan, J.M., Normolle, D., Boyiadzis, M., Hou, J.Z., Swerdlow, S.H., Dorritie, K. "Location matters in early stage nodal diffuse large B-cell lymphoma, (Letter), Leuk Lymphoma, 2019, 60(1):250-253
  • Agha, M.E., Monaghan, S.A., Swerdlow, S.H., "More on Blastic Plasmacytoid Dendritic-cell Neoplasms", (letter) N Engl J Med. 2019, 380(7):696-697.
  • Qayyum, S., Bullock, G., Swerdlow, S.H., Brower, R., Nikiforova, M., Aggarwal, N., "Diagnostic utility of isolated tube C positivity in T-cell receptor beta testing using BIOMED-2 primers". Am J Clin Pathol. 2019, 151 (4):386-394.
  • Soma, L., Kovach, A., Siddon, A., Beck, R., Gibson, S., Swerdlow, S.H., Kim, A., Wu, D., Jones, D., Cook, J., Prakash, S., Rosago, F., Crane, G., Bradley, K., Weinberg, O., Sargent, R., "Molecular and Cytogenetic Education in Hematopathology Fellowship: Proceedings from the Society for Hematopathology, 2018 Program Directors Meeting", Am J Clin Pathol, 2019 Sept 9;152(4):438-445
  • Leeman-Neill, R.J., Swerdlow, S.H, Burnes, C.L., Melan, M.A., Nikiforova, M., Surti, U., Aggarwal, N., Low-Level BCR-ABL1 Transcripts in Individuals without Overt Hematologic Malignancy, Leuk Res, (Letter), 2019, 81:98-101
  • Cascione, L., Rinaldi, A., Bruscaggin, A., Tarantelli, C., Arribas, A., Kwee, I., Pecciarini, L., Mensah, A., Spina, V., Chung, E., Dirnhofer, S., Tzankov, A., Young, K., Traverse-Glehen, A., Gaidano, G., Swerdlow, S.H., Gascoyne, R., Rabadan, R., Ponzoni, M., Bhagat, G., Rossi. D., Zucca, E., Bertoni, F., "Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses" Haematologica, 2019 Dec;104(12):e558-e561.
  • Swerdlow, S.H., Monaghan, S., Douglas, A., Johnson, K., Johnson, R.L., "Harmonization of training, training requirements, board certification and practice of hematopathology", Am J Clin Pathol, 2019; 152:625-637
  • Carlsen, E.D., Swerdlow, S.H., Cook, J.R., Gibson, S.E., "Class-switched primary cutaneous marginal zone lymphomas are frequently IgG4-positive and have features distinct from IgM-positive cases", Am J Surg Pathol, 2019 Oct;43(10):1403-1412
  • Fuster, C., Martin-Garcia, D., Balagué, O., Navarro, A., Nadeu, F., Costa, D., Prieto, M., Salaverria, I., Espinet, B., Rivas-Delgado, A., Terol, M.J., Giné, E., Forcada, P., Ashton-Key, M., Puente, X. S., Swerdlow, S.H., Beá, S., Campo, E., "Cryptic insertions of the IG light chain enhancer region near CCND1 in t(11;14)-negative mantle cell lymphoma" (letter) Haematologica, 2020 Aug;105(8):e408-e411.
  • Egan, C., Laurent, C., Alejo, J., Pileri, S., Campo, E., Swerdlow, S.H., Piris, M., Chan, W., Warnke, R., Gasoyne, R. D., Xi, L., Raffeld, M., Pittaluga, S., Jaffe, E. S., "Expansion of PD1-positive T cells in nodal marginal zone lymphoma - a potential diagnostic pitfall" American Journal of Surgical Pathology, 2020, May;44(5):657-664
  • Barasch, N.J.K., Liu, Y.C, Ho, J., Bailey, N., Aggarwal, N., Cook, J.R., Swerdlow, S.H., "The Molecular Landscape and Other Distinctive Features of Primary Cutaneous Follicle Center Lymphoma" Hum Pathol. 2020 Dec;106:93-105
  • Wang, X. J., Moore, E. M., Swerdlow, S. H., Aggarwal, N., "Light chain restricted plasmacytoid cells in hyperplastic germinal centers: A clinicopathologic investigation" American Journal of Clinical Pathology 2021 (in press)(selected for CME activity)

Reviews, invited published papers, proceedings of conferences abd symposia, monographs, books and book chapters:

  • Ferry, J.A., Jansen, P.M., Swerdlow, S.H., Cutaneous involvement in primarily extracutaneous B-cell lymphomas and leukaemias, In: Elder, D., Massi, D., Scolyer, R., Willemze, R., (Eds): WHO Classification of Skin Tumors, 4th Edition, IARC, Lyon, 2018: 266-269
  • Kempf, W., Duncan, L.M., Swerdlow, S.H., Willemze, R., Primary Cutaneous Marginal Zone (MALT) Lymphoma, In: Elder, D., Massi, D., Scolyer, R., Willemze, R., (Eds): WHO Classification of skin tumours, 4th Edition, IARC, Lyon , 2018: 256-257
  • Swerdlow, S.H., Cook, J.R., "As the world turns, evolving lymphoma classifications - past, present and future", Human Pathology, 2020, 95:55-77 (Invited review for 50th Anniversary Issue)
  • Gibson, S.E., Swerdlow, S. H., "How I Diagnose Primary Cutaneous Marginal Zone Lymphoma" Am J Clin Pathol. 2020, 154:428-449. (selected for CME activity)
  • Swerdlow, S.H., Akilov, O., "Case 15, De novo expression of CD26 on Sezary cells as an indicator of the disease progression in a patient with Sezary syndrome". Cutaneous Lymphomas. Unusual Cases (3rd edition) Burg, G., LeBoit, P.E., Kempf, W., Müller, B., (Eds. of prior edition) Springer Nature Switzerland, 2021, Pages 32-33
  • Swerdlow, S.H, Webber, S.A "Definitions and Pathology of PTLD", in Post-Transplant Lymphoproliferative Disorders (2nd edition), Dharnidharka, VR, Green, M, Webber, SA, Trappe, RU (Eds), Springer Nature Switzerland, 2021, pages 9-26