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High Throughput Genome Center

Depathment of Pathology

School of Medicine

University of Pittsburgh


Selected Recent Publications Utilizing HTGC

  1. Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK (2018). Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice. Am J Pathol. 2018 Jul 20. [link]
  2. Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK (2018). TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling. Hepatology. [link]
  3. Danielle Bell, Junyan Tao, Minakshi Poddar, Sucha Singh, Tirthadipa Pradhan-Sundd, Sarangarajan Ranganathan, Miss Morgan Preziosi, Laura Molina, Maria Chikina, Jianhua Luo and Satdarshan P Monga (2018). Hepatocyte-derived lipocalin 2 is a potential serum biomarker reflecting tumor burden in hepatoblastoma. American Journal of Pathology, 188(8):1895-1909. [link]
  4. Duangrat Tantikanlayaporn, Irina L Tourkova, Quitterie Larrouture, Jianhua Luo, Pawinee Piyachaturawat, Michelle R Witt, Harry C Blai and Lisa J Robinson (2018). Sphingosine-1-Phosphate Modulates the Effect of Estrogen in Human Osteoblasts. Journal of Bone and Mineral Research Plus. [link]
  5. Tourkova, I. L., Liu, L., Sutjarit, N., Larrouture, Q. C., Luo, J., Robinson, L. J., & Blair, H. C. (2017). Adrenocorticotropic hormone and 1, 25-dihydroxyvitamin D 3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes. Laboratory Investigation, 97(9), 1072. [link]
  6. Dong-Mei He, Bao-Guo Ren, Silvia Liu, Lang-Zhu Tan, Kathleen Cieply, George Tseng, Yan P. Yu and Jian-Hua Luo (2017). Oncogenic Activity of Amplified Miniature Chromosome Maintenance 8 in Human Malignancies. Oncogene 36, 3629-3639. [link]
  7. Zhang-Hui Chen, Yan P. Yu, Ze-Hua Zuo, Joel B. Nelson+, George K. Michalopoulos, Satdatshan Monga, Silvia Liu, George Tseng and Jian-Hua Luo (2017). Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene. Nature Biotechnology 35, 543-550. [link]
  8. Zhang-Hui Chen, Yan P. Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B. Nelson, Arjun Pennathur, Satdarshan P Monga, James D. Luketich, George K. Michalopoulos and Jian-Hua Luo (2017). MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology, 153:1120–1132. [link]
  9. Changshun Yu, Shengmin Yan, Bilon Khambu, Xiaoyun Chen, Zheng Dong, Jianhua Luo, George K. Michalopoulos, Shangwei Wu, Xiao-Ming Yin (2016). Gene Expression Analysis Indicates Divergent Mechanisms in DEN-induced Carcinogenesis in Wild Type and Bid-deficient Livers. PLOS ONE, 11(5): e0155211. [link]
  10. Ze-Hua Zuo, Yan P. Yu, Amantha Martin and Jian-Hua Luo (2017). Cellular stress response 1 down-regulates the expression of epidermal growth factor receptor and platelet-derived growth factor receptor through inactivation of splicing factor 3A3. Molecular Carcinogenesis, 56(2):315-324. [link]
  11. Liu, Silvia; Tsai, Wei-Hsiang; Ding, Ying; Chen, Rui; Fang, Zhou; Huo, Zhiguang; Kim, Sung Hwan; Ma, Tianzhou; Chang, Ting-Yu; Priedigkeit, Nolan; Lee, Adrian; Luo, Jianhua; Wang, Hsei-Wei; Chung, I-Fang and Tseng, George (2016). Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Research 44: e47. [link]
  12. Yan P. Yu, Silvia Liu, Zhiguang Huo, Amantha Martin, Joel B. Nelson, George C. Tseng and Jian-Hua Luo (2015). Genomic copy number variations in the genomes of leukocytes predict prostate cancer clinical outcomes. PLOS ONE, 10(8):e0135982. [link]
  13. Wang T, Guan W, Lin J, Boutaoui N, Canino G, Luo J, Celedón JC, Chen W (2015). A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data. Epigenetics 10(7):662-9. [link]
  14. Ze-Hua Zuo, Yan P. Yu, Ying Ding, Silvia Liu, Amantha Martin, George Tseng and Jian-Hua Luo (2015). Oncogenic activity of miRNA 650 in prostate cancer is mediated by suppression of CSR1 expression. American Journal of Pathology 185(7):1991-9. [link]
  15. Jian-Hua Luo, Silvia Liu, Ze-Hua Zuo, Rui Chen, George C. Tseng and Yan P. Yu (2015). Discovery and classification of fusion transcripts in prostate cancer and normal prostate tissue. American Journal of Pathology 185(7):1834-45. [link]
  16. Zhang-Hui Chen, Yan P. Yu, George Michalopoulos, Joel Nelson and Jian-Hua Luo (2015). The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-met and platelet derived growth factor receptor. Journal of Biological Chemistry, 290(3):1404-11. [link]
  17. Kelly Koral, Shirish Paranjpe, William Bowen, Wendy Mars, Jianhua Luo and George K. Michalopoulos (2015). Leukocyte Specific Protein-1: a novel regulator of hepatocellular proliferation and migration deleted in human HCC. Hepatology 61(2):537-47. [link]
  18. Irina L. Tourkova, Michelle R. Witt, La Li,a Quitterie Larrouture, Li Liu, Jianhua Luo, Lisa J. Robinson, and Harry C. Blair (2014). Follicle Stimulating Hormone Receptor in Mesenchymal Stem Cells Integrates Effects of Glycoprotein Reproductive Hormones. Marrow-Annals of the New York Academy of Sciences, 2015 Jan;1335(1):100-9. [link]
  19. Yan P. Yu, Ying Ding, Zhanghui Chen, Silvia Liu, Amantha Michalopoulos, Rui Chen, Zulfiqar G. Gulzar, Bing Yang, Kathleen Cieply, Alyssa Luvison, Bao-Guo Ren, James D. Brooks, David Jarrard, Joel B. Nelson, George Michalopoulos, George C. Tseng and Jian-Hua Luo (2014). Novel fusion transcripts associate with progressive prostate cancer. American Journal of Pathology, 184, 2840-9. [link]
  20. Yan P. Yu, Amantha Martin, Ding Ying, George Tseng and Jian-Hua Luo (2014). High Fidelity Copy Number Analysis of Formalin-Fixed and Paraffin-Embedded Tissues Using Affymetrix Cytoscan HD Chip. PLOS ONE 9(4):e92820. [link]
  21. Lindsey M. Kelly, Guillermo Barila, Pengyuan Liu, Viktoria N Evdokimova, Sumita Trivedi, Federica Panebianco, Manoj Gadhi, Sally E. Carty Steven Hodak, Jianhua Luo, Sanja Dacic, Yan P Yu, Marina N Nikiforova, Robert L. Ferris, Daniel L. Altschuler and Yuri E Nikiforov (2014). Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer. The Proceedings of National Academy of Sciences of USA, 111(11):4233-8. [link]
  22. Yan P. Yu, Ying Ding, Rui Chen, Serena G. Liao, Bao-Guo Ren, Amantha Michalopoulos, George Michalopoulos, Joel Nelson, George C. Tseng and Jian-Hua Luo (2013). Whole genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer. American Journal of Pathology 183, 1960-1970. [link]
  23. Sarah E. Gibson, Jianhua Luo, Malini Sathanoori, Jun Liao, Urvashi Surti, George K. Michalopoulos and Steven H. Swerdlow (2014). Whole Genome Single Nucleotide Polymorphism Array Analysis is Complementary to Classical Cytogenetic Analysis in the Evaluation of Lymphoid Proliferations. American Journal of Clinical Pathology 141, 247-255. [link]