Wells' Lab - Hidenori Shiraha

Okayama University Graduate School of Medicine and Dentistry
Department of Medicine and Medical Science (Medicine 1)
2-5-1 Shikata-cho
Okayama 700-8558, Japan
Phone +81-86-235-7219
FAX +81-86-235-7345



Institution Degree Conferred Field of study
Okayama University, Japan MD 1992 Medicine
Okayama University, Japan PhD 1996 Internal Medicine 
Okayama University, Japan Research fellow 1996-97  Hepatology
University of Alabama at Birmingham Postdoctoral 1997-99 Cell Biology fellow
University of Pittsburgh Postdoctoral 2002 Cell Biology fellow


1. T Tamura, N Koide, H Hada, H Shiraha, and T Tsuji (1995). Gene expression of liver-specific proteins in hepatocyte spheroids in primary culture. Acta Medica Okayama 49(3):161-167

2. T Ito, M Ukida, K Yamamoto, H Kobashi, Y Morimoto, M Mikami, M Omoto, S Nakanishi, K Shinmen,T  Nagano, S Matsumoto, M Nakamura, R Okamoto, S Fujioka, N Omori, K Ujike, H Shiraha, and T Tsuji (1995). Diagnostic accuracy of laparoscopic liver biopsy in chronic liver disease, Comparison of laparoscopic and US-guided liver biopsy results.Digestive Endoscopy 7: 261-265

3. H Shiraha, N Koide, H Hada, K Ujike, K, M Nakamura, T Shinji, S Gotoh, and T Tsuji (1996). Improvement of serum amino acid profile in hepatic failure with the bio-artificial liver using multicellular hepatocyte spheroids. Biotechnologies and Bioengineering 50: 416-421

4. T Morita, H Hada, N Koide, T Shinji, H Shiraha, M Nakamura, K Ujike, M Wato, H Shimomura, and T Tsuji (1996). Detection of hepatitis C virus RNA in circulating immune complexes by RT-PCR. Hepato-Gastroenterology43(9):582-585

5. H Hada, N Koide, T Morita, H Shiraha, T Shinji, M Nakamura, K Ujike, N Takayama, T Oka, T Hanafusa, Y Yumoto, K Hamazaki, and T Tsuji (1996). Promoter-independent loss of mRNA and protein of the Rb gene in a human hepatocellular carcinoma. Hepato-Gastroenterology 43(11): 1185-1189

6. T Shinji. N Koide. H Hada. S Sasaki. T Oka. N Takayama. H Shiraha. K Ujike. M Nakamura.  T Hanafusa. Y Yumoto. T Tsuji (1997). Reciprocal gene expression of rat fibroglycan and beta-actin during the course of regeneration after D-galactosamine liver injury. Hepato-Gastroenterology 44(13): 239-244

7. T Shinji. N Koide. T Hanafusa. H Hada. T Oka. N Takayama. H Shiraha. M Nakamura. K Ujike. Y Yumoto. T Tsuji (1998). Point mutations in the S and pre-S2 genes observed in two hepatitis B virus carriers positive for antibody to hepatitis B surface antigen. Hepato-Gastroenterology 45(20): 500-502

8. A Wells, K Gupta, P Chang, S Swindle, A Glading, H Shiraha (1998). Epidermal growth factor receptor-mediated motility in fibroblasts. Microscopy Research and Technique 43: 395-411

9. H Shiraha, K Gupta, A Glading, and A Wells (1999). IP-10 inhibits EGF-induced motility by decreasing EGF receptor-mediated calpain activity. Journal of Cell Biology 146(1); 243-253, 1999

10. H Shiraha, K Gupta, KA Drabik, A Wells (2000).  Preferential loss of epiderml growth factor receptor results in reduced responsiveness in aging dermal fibroblasts.  Journal of Biological Chemistry 275, 19343-19351.