Microscopic Description -- history of colonic adenocarcinoma


The normal small intestinal villi and crypts are well represented (FIGURE 1). Further along the mucosal surface of this slide, there is an abrupt transition from the benign appearing columnar epithelium to more hyperchromatic nuclei and adenomatous appearing epithelium (FIGURE 2). The architecture is that of a villous adenoma. The progression of this adenoma towards a well differentiated mucin producing adenocarcinoma is evident by the nuclear stratification, prominent nucleoli, increased nuclear to cytoplasmic ratio, and nuclear pleomorphism (FIGURES 3, FIGURE 4, and FIGURE 5). There is also evidence of invasion into the muscularis mucosa with extension through the bowel wall. The invasive adenocarcinoma approached the hepatic capsule but did not invade the hepatic parenchyma (FIGURE 6).



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