Samuel A. Yousem, MD
E. Leon Barnes Professor of Anatomic Pathology

Dr. Yousem Dr. Yousem is the Vice Chairman of Anatomic Pathology Services at UPMC, Director of the Division of Anatomic Pathology, and Co-Director of the Community Pathology Division.

Office Location:
Department of Pathology C620
UPMC Presbyterian
200 Lothrop Street
Pittsburgh, PA 15213-2582
Contact Information:
Office Telephone: 412-647-6193
Fax: 412-647-3399


  • BS - 1977, Duke University
  • MD - 1981, University of Maryland School of Medicine

Clinical Expertise

Dr. Yousem is a general surgical pathologist who has devoted the last ten years of his practice to focus on thoracic pathology. This expertise extends from inflammatory to neoplastic thoracic pathology. Perhaps his greatest impact has been in the area of pulmonary allograft pathology where Dr. Yousem, working at Stanford University and The University of Pittsburgh defined the histopathology of pulmonary allograft rejection and its variations and has been responsible for the three major revisions of international standards creating a working formulation for the standardization of nomenclature in the diagnosis of lung rejection. This effort most recently has focused on defining criteria for antibody mediated rejection in the lung allograft. At the same time Dr. Yousem has a great interest in chronic fibrosing interstitial lung disease, and has written extensively on the pathology of usual interstitial pneumonia, nonspecific interstitial pneumonia, respiratory bronchiolitis, smoking induced interstitial fibrosis, and pulmonary vasculitis.

In recent years, working with his colleague Sanja Dacic, MD PhD, his academic focus has been on the specific molecular drivers of pulmonary neoplasia, their association with specific histopathologies, and the prediction of biologic behavior based on molecular and histopathologic alterations. This interest has extended to a wide variety of unusual pulmonary malignancies, where the molecular pathology has in large part been defined by our molecular thoracic group, including studies of bronchioalveolar carcinoma/adenocarcinoma in situ, atypical adenomatous hyperplasia, sclerosing hemangioma of lung, chemodectomas, Langerhans cell histiocytosis, adenosquamous carcinoma and micropapillary adenocarcinoma. Dr. Yousem leads one of the most academically productive and internationally recognized sections in thoracic pathology in the world and as a result, he was recently presented with an endowed chair, the E. Leon Barnes Professor of Anatomic Pathology.

Research Interests

As indicated above, Dr. Yousem has focused his energies on three areas of pathology: inflammatory lung disease, pathology of lung allografts, and the molecular alterations in pulmonary neoplasia. In each of these areas he is certainly regarded as one of the world leaders in correlating special studies including immunohistochemistry, fluorescence in situ hybridization, and molecular techniques with histopathology in an attempt to expand the differential diagnosis, prognostic importance, and pathobiology of thoracic inflammatory and neoplastic disease. Most recently, he has worked to re-define the spectrum of lung injury associated with cigarette smoking, e.g. smoking induced fibrosis, and on anti-synthetase syndrome associated lung disease.


Anatomic Pathology: Cytopathology


Thoracic Pathology

Awards and Honors

E. Leon Barnes Professor of Surgical Pathology, 2012 - endowed chair

Selected Publications

View Dr. Yousem's publications on PubMed

  • Zhao C, Wu T, Ding X, Parwani AV, Chen H, McHugh J, Piccoli A, Xie Q, Lauro GR, Feng X, Hartman DJ, Seethala RR, Wu S, Yousem S, Liang Y, Pantanowitz L. International telepathology consultation: Three years of experience between the University of Pittsburgh Medical Center and KingMed Diagnostics in China. J Pathol Inform. 2015 Nov 27;6:63. doi: 10.4103/2153-3539.170650. eCollection 2015.
  • Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015 Dec 11;290(50):29742-57. doi: 10.1074/jbc.M115.691253. Epub 2015 Oct 22.
  • Walsh SL, Wells AU, Sverzellati N, Devaraj A, von der Thüsen J, Yousem SA, Colby TV, Nicholson AG, Hansell DM. Relationship between fibroblastic foci profusion and high resolution CT morphology in fibrotic lung disease. BMC Med. 2015 Sep 24;13:241. doi: 10.1186/s12916-015-0479-0.
  • Aggarwal R, McBurney C, Schneider F, Yousem S, Gibson K, Lindell K, Fuhrman C, Koontz D, Oddis CV. Myositis-Associated Usual Interstitial Pneumonia Has a Better Survival Than Idiopathic Pulmonary fibrosis. Submitted to Arthritis and Rheumatism.
  • Guo H, Birsa J, Farahani N, Hartman DJ, Piccoli A, O'Leary M, McHugh J, Nyman M, Stratman C, Kvarnstrom V, Yousem S, Pantanowitz L. Digital pathology and anatomic pathology laboratory information system integration to support digital pathology sign-out. J Pathol Inform 7:23 2016; doi: 10.4103/2153-3539.181767.