Clayton A. Wiley, MD, PhD
Professor of Pathology
PERF Endowed Chair

Dr. Wiley
Dr. Wiley is Director of the Division of Neuropathology. In addition to clinical sign out, Dr. Wiley directs the Neuropathology fellowship program and runs an NIH funded research program studying neuroinflammation and viral encephalitis in particular.

Office Location:
S701.4 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-624-0764
Fax: 412-624-5610
Email Address:


  • MD - University of California, San Diego, 1981
  • PhD - University of California, San Diego 1981


Board certified in AP and NP 1985



Awards and Honors

Fellow American Association for Advancement of Science

Clinical Experties

Board certified in Neuropathology with specific expertise in infectious disease

Research Interests

Dr. Wiley's research concentrates on the pathogenesis of neurodegenerative diseases and in particular on viral and age induced nervous system diseases. Viruses damage the nervous system either by direct infection of neural cells or by secondary effects of an immune response. In recent years his studies have focused on central nervous system influenza and retroviral infections and have pioneered the use of molecular and imaging techniques to quantitatively assess viral burden. This same technology is now being applied to quantify neurological damage and the immune / neuroinflammatory response with specific attention focused on disruption of the extracellular matrix and how this leads to synaptic damage.

Trainees in Dr. Wiley's laboratory have the opportunity to learn a wide variety of techniques related to studying degeneration of the nervous system. Both whole organism and tissue culture techniques are available using histological techniques that include; immunocytochemistry, in situ hybridization and ultrastructural analysis. Training on laser confocal and electron microscopes is available. Protein techniques include; antibody purification and tagging. Molecular techniques include; RNA and DNA extraction from tissues, competitive PCR probe construction and quantitation. Lab rotation projects involve quantitation of mRNA and protein expression in rodent, human and non-human primate nervous system tissue in vivo or in vitro.

Selected Publications

View Dr. Wiley's publications on PubMed

Bissel SJ, Giles BM, Wang G, Olevian DC, Ross TM, Wiley CA. Acute Murine H5N1 Influenza A Encephalitis. Brain Pathol (2012) 22(2):150-158. PMCID: PMC3204170

Kofler J, Lopresti B, Janssen C, Trichel AM, Masliah E, Finn OJ, Salter RD, Murdoch GH, Mathis CA and Wiley CA: Preventive immunization of aged and juvenile non-human primates to β-amyloid. J Neuroinflammation (2012) 9:84 PMCID: PMC3495408.

Clark KH, Wiley CA and Bradberry CW: Psychostimulant abuse and neuroinflammation: Emerging evidence of their interconnection. (2013) Neurotoxicity Research 23:174-188 PMID: 22714667

Venneti S, Lopresti BJ and Wiley CA: Molecular imaging of microglia/macrophages in the brain. Glia 61:10-23, (2013) DOI: 10.1002/glia.22357. Epub 2012 May 21. PMCID: PMC3580157

Bissel SJ, Wang G, Carter DM, Crevar CJ, Ross TM, Wiley CA. H1N1, but Not N3N2, Influenza A Virus Infection Protects Ferrets from H5N1 Encephalitis. J Virol (2014) 88(6):3077-3091. PMCID: PMC3957958

Bissel SJ, Winkler CC, DelTondo J, Wang G, Williams K and Wiley CA. Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins. Neuropathology (2014) 34, 429-437 Apr 7. doi: 10.1111/neup.12121. PMCID: PMC4188796 Wiley CA, Bonneh-Barkay D, Dixon CE, Lesniak A, Wang G, Bissel SJ and Kochanek PM: Role for mammalian chitinase 3-like protein 1 in traumatic brain injury. Neuropathology (2015) 35:95-106. PMID: 25377763

Bissel SJ, Auer R, Chiang C-H, Kofler J, Murdoch GH, Nix WA, Painter M, Richer M, Startelet H and Wiley CA: Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. J Neuropathology and Experimental Neurology (2015) PMID: 26115191