Uma N. M. Rao, MD
Professor of Pathology

Dr. Uma Rao is a member of the Division of Anatomic Pathology and Director of the Bone, Soft Tissue, and Melanoma Center of Excellence.

Office Location:
UPMC Shadyside
Department of Pathology WG2.9
5230 Centre Avenue
Pittsburgh, PA 15232
Contact Information:
Office Telephone: 412-623-2319
Lab Telephone: 412-623-2318
Fax: 412-682-6450

Dr. Rao is a surgical pathologist interested in Oncology in general with focus on bone and soft tissue tumors and melanoma. Her diagnostic and research interests include utilization of Cytogenetic, Immunohistochemical and Molecular techniques in the analysis of these neoplasms.

She is the Director of the ACGME approved Bone and Soft tissue Pathology Fellowship program at UPMC.

Dr. Rao is active in teaching and mentoring Pathology and Podiatry residents and Dermatology Fellows who rotate in Bone Soft tissue and Melanoma bench


  • MBBS - Government Medical College, Mysore University, Mysore, India, 1968

Clinical Expertise

Bone and Soft Tissue: Close interaction with orthopedic oncology a, medical oncology and radiology in pathological diagnosis and patient care activities. Participates in general surgical pathology intraoperative consultations at UPMC Shadyside. Pathology consultant for interdepartmental and extradepartmental cases

Melanoma: She is the reference pathologist for the melanoma center at UPCI. Active and major participant in the Melanoma section of the Eastern Cooperative Oncology Group and involved in multicenter and UPCI clinical trials.

Pathology consultant for interdepartmental and extradepartmental cases.

Research Interests

Cytogenetic and Mmolecular analysis of Bone and Soft tissue tumors and Melanoma. Works with FISH and Molecular Anatomic Pathology Laboratories (current) Genomic/ Proteomic Laboratories (past)

Selected Publications

View Dr. Rao's publications on PubMed

Rao UN, Cieply K, Sherer C, Surti U, Gollin SM. Correlation of Classic and Molecular Cytogenetic Alterations in Soft-Tissue Sarcomas: Analysis of 46 Tumors With Emphasis on Adipocytic Tumors and Synovial Sarcoma. Appl Immunohistochem Mol Morphol. 2016 Jan 22. [Epub ahead of print]

Wang T, Goodman MA, McGough RL, Weiss KR, Rao UN. Immunohistochemical Analysis of Expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B Is Helpful in Distinction of Myxofibrosarcoma and Myxoid Liposarcoma. Int J Surg Pathol. 2014 Apr 29. [Epub ahead of print], PMID: 24788530

Rao UN, Hood BL, Jones-Laughner JM, Sun M, Conrads TP. Distinct profiles of oxidative stress-related and matrix proteins in adult bone and soft tissue osteosarcoma and desmoid tumors: A proteomics study. Human Pathology. 2013.44; 725-33

Papachristou DJ, Sklirou E, Corradi D, Grassani C, Kontogeorgakos V, Rao UN. Immunohistochemical analysis of the endo ribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues. Histopathology. 2012; 60; E280-36

Papachristou DJ, Rao UN, Korpetinou A, Giannopoulou E, Sklirou E, Kontogeorgakos V, Kalofonos HP. Prognostic significance of Dicer cellular levels in soft tissue sarcomas. Cancer Invest. 2011 Feb;30(2):172-9.

Cajaiba MM, Jianhua Luo, Goodman MA, Fuhrer KA, Rao UN. Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. Int J Surg Pathol. 2010 Oct;18(5):319-23.

Jukic DM, Rao UN, Kelly L, Skaf JS, Drogowski LM, Kirkwood JM, Panelli MC. Microrna profiling analysis of differences between the melanoma of young adults and older adults. J Transl Med. 2010 Mar 19;8(1):27.

Rao UN, Lee SJ, Luo W, Mihm MC Jr, Kirkwood JM. Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials. Am J Clin Pathol. 2010 Apr;133(4):646-53.