Parmjeet S. Randhawa, MD
Professor of Pathology
Dr. Randhawa is a member of the Division of Transplantation Pathology.
Division of Transplantation Pathology
Department of Pathology
UPMC-Montefiore, Room E-737
3459 5th Avenue
Pittsburgh, PA 15213
Office Phone: 412-647-7646
Dr. Randhawa is one of five pathologists in the Division of Transplant Pathology. He has special expertise in the evaluation of native and kidney transplant biopsies. Difficult consult cases in this area are regularly referred to him for his opinion. He is the Course Director of a weekly multidisciplinary clinical conference on kidney allograft pathology. He is an established investigator with a long history of successful funding in the area of polyomavirus infections after kidney transplantation. He teaches medical students, residents and fellows and is regular speaker in national and international meetings focusing on renal transplantation.
Pathologic evaluation of native, donor and allograft liver, kidney and heart, allograft small intestine and pancreas biopsies and surgical resections. He is lead patholgist for the University of Pittsburgh Kidney Transplantation Program with unmatched experience in the light microscopic, immunofluorescence and ultratructural evaluation of kidney biopsies.
The clinical profile of patients with BK virus infection in the renal allograft is being defined. DNA sequencing of viral strains is being used to define mutations and genomic rearrangements, which may be relevant to the pathogenesis of an extremely refractory interstitial nephritis seen in these individuals. Quantitative PCR assays have been developed to measure viral load in biopsy samples and body fluids to better manage the immunosuppression levels in these patients. The interplay between host and viral immune factors in this disease is being investigated by cellular immunology, miRNA and RNAseq techniques. Drugs with antiviral activity are being screened in an in-vitro culture model for possible future use in the clinical arena. Efforts are underway to develop a mouse model of polyomavirus nephropathy that better mimics human disease than currently available models.
Anatomic Pathology, Transplantation Pathology, Hepatic Pathology, Renal Pathology
Honors and Awards
- Associate Editor, American Journal of Transplantation (2012) & American Journal of Kidney Diseases (2011)
- Founding Member, American Society of Transplantation, Transplant Diagnostics Community of Practice, 2011
- Mentorship, Stephen Vogel Award, in recognition of an outstanding paper published by a resident or fellow in a journal of the US & Canadian Academy of Pathology, 2010.
- Distinguished Alumnus Award, University of Delhi, 2009.
- Fellowship, National Center for Drug Discovery in Neurodegeneration, Harvard Medical School, 2009
- Mentorship, College of American Pathologists Research, Scholars Grant, 2009
- Chair, Special Emphasis Panel, Urologic & Kid Development & Genitourinary Diseases Study Section, April 2009
- Distinguished Alumnus Award, Maulana Azad Medical College, Delhi University, 2009
- Co-chair, Early Morning Workshop on BK virus, World Transplant Congress, Sydney, August 2008
- Chair, Sunrise Symposium, State of the Art; BK virus and Polyomavirus Allograft Nephropathy, American Transplant Congress, San Francisco, May 2007
- Mentorship Award for Thomas E. Starzl Institute Fellow in Transplantation Biology, 2007
- Fellowship of The American Society of Nephrology, 2004
- Co-chair, Free Communications Session: BKV nephropathy, Am Soc Nephrology Meeting, San Diego, 2003
- Chair: Plenary Session: Viral Infection in Allografts. Banff Congress on Allograft Pathology, Banff, Alberta, 2001
- Member of Editorial Board, Journal of Transplantation, Liver Transplantation, World Journal of Gastroenterologic Oncology, Aegian Journal of Pathology, Indian Journal of Biotechnology
NIH ResearchView Dr. Randhawa's NIH RePORT on nih.gov
Selected PublicationsView Dr. Randhawa's publications on PubMed
- P. Randhawa, G. Zeng, M. Bueno-Fernandez, A. Salgarkar, A. Lesniak, MS, K. Isse, K. Seyb, A. Perry, I. Charles, C.Hustus, M. Huang, M.Smith, M. Glicksman. Inhibtion of large T antigen ATPase activity a potential strategy to develop anti-JCV drugs. Antiviral Research, 2014: 112: 113-119.
- P. Randhawa, Diana V. Pastrana, Gang Zeng, Yuchen Huang, Ron Shapiro, Puneet Sood, Chethan Putttarappa, Mel Berger, Sundaram Hariharan, Christopher B. Buck. Commercially available immunoglobulins contain virus neutralizing antibodies against all major genotypes of polyomavirus BK. Am J Transplantation, 2015: 15: 1014-1020.
- P. Sood, P. Randhawa, Mehta R, Hariharan H, Tevar A. Donor kidney microthrombi and outcomes of kidney transplant: a single center experience. Clin Transplant 2015, Mar 4. doi: 10.1111/ctr.12539. [Epub ahead of print].
- Momper JD, Zhao Y, Shapiro R, Schonder KS, Yao G, Randhawa PS, Venkataramanan R. Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK virus infection. Transpl Infect Dis. 15:34-41, 2013.
- Randhawa PS and Borislav Alexiev (equal contribution authors, Gang Zeng, Chunquing Luo, Eduardo Vazquez Martul,Cinthia B. Drachenberg,and John C. Papadimitriou. BK Virus Associated Urinary Bladder Carcinoma in Transplant Recipients: Proposed pathogenetic model. Human Pathology. 44: 908-917, 2013.
- Mengel M, Samantha Chan, Jessie Climenhaga, Yael B Kushner, Heinz Regele, Robert B Colvin, Randhawa PS. Banff Initiative For Quality Assurance in Transplantation (BIFQUIT):Reproducibility assessment for C4d immunohistochemistry in kidney allografts. Am J Transplant. 13: 1235-45, 2013.
- Mengel M, Campbell P, Gebel H, Randhawa P, Rodriguez ER, Colvin R, Conway J, Hachem R, Halloran P, Keshavjee S, Nickerson P, Murphyey C, O'Leary J, Reeve J, Tinckam K, Reed EF. Precision diagnostics in transplantation:from bench to bedside. Am J Transplantation 2013: 13: 562-8.
- Hirsch HH, Randhawa P: AST Infectious Diseases Community of Practice. BK polyomavirus in solid organ transplantation. Am J Transplant 2013:13 (suppl 4): 179-188.
- Masutani K, Ninomiya T, Randhawa P. HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia. Nephrol Dial Transplant 28:3119-3126, 2013.]
- Castilo-Rama M, Sebagh M, Sasatomi E, Randhawa P, Isse K, Salgarkar AD, Ruppert K, Humar A, Demetris AJ. Plasma Cell Hepatitis" in Liver Allografts: Identification and Characterization of an IgG4-Rich Cohort. Am J Transplant. 2013, 13: 2966-77.
- Hirsch HH, Randhawa P: AST Infectious Diseases Community of Practice. BK polyomavirus in solid organ transplantation. Am J Transplant 2013: 13 (suppl 4): 179-188.
- Hirsch H, Babel N, Commoli P, Friman V, Ginervri F, Jardine A, Lautenschlager I, Legendre C, Midtvedt K, Munoz P, Randhawa P, Wiecek A: European perspective on human polyomavirus infection, replication and disease in solid organ transplantation. Clin Microbiol Infect. 2014 Jan 29. doi: 10.1111/1469-0691.12538. [Epub ahead of print]
- Randhawa PS. Mechanistic aspects of cell mediated rejection. In: Pathobiology of Human Disease: A Dynamic Encylopedia of Disease Mechanisms, (Linda McManus and Richard Mitchell, Editors), 2013, Elsevier Ltd, Oxford, UK.
- Randhawa PS. BK Polyomavirus (BK virus). In: Antimicrobial Therapy and Vaccines. (Victor Yu, Editor in Chief), ESun Technologies and Antimicrobe.org, 2014, www.antimicrobe.org.
- Randhawa P. Incorporation of pathology and laboratory findings into management algorithms for polyomavirus nephropathy. Am J Transplant, 2013, 13; 1379-81.
- Zeng Q, Sheriff KA, Ng Y-H, Zahalka S, Li Q, Ramaswami B, Randhawa P, Hoffman R, Lund FE, Chalasani G: B cells mediate chronic allograft rejection independent of antibody production. J Clin Invest. 2014, 124: 1052-56.
- Randhawa P*, Adam B*, (*Equal Contribution Authors) Chan S, Zeng G, Regele H, Kushner Y, Colvin RB, Reeve J and Mengel M: Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of Polyomavirus Immunohistochemistry in Kidney Allografts. Am J Transplant 2014, 14: 2137-47.