Parmjeet S. Randhawa, MD
Professor of Pathology
Dr. Randhawa is a member of the Division of Transplantation Pathology.
Division of Transplantation Pathology
Department of Pathology
UPMC-Montefiore, Room E-737
3459 5th Avenue
Pittsburgh, PA 15213
Office Phone: 412-647-7646
Dr. Randhawa is a physician-investigator. He runs a research virology laboratory which has been successful in obtaining funding from the NIH as well as the pharmaceutical industry. He mentors technical staff and post-doctoral research fellows. He participates in the teaching of medical students, residents, fellows and visiting physicians who come to observe in the Division of Transplantation Pathology from all over the world.
He is the Course Director of a CME Accredited Weekly Allograft Biopsy Conference. He frequently lectures on Transplant Pathology and his laboratory research in national and international forums.
As a part of his clinical service he:
- signs native and allograft liver, kidney, heart, pancreas and small intestinal pathology specimens accessioned at the Division of Transplantation Pathology
- rotates on the Frozen section service on donor organs referred by the Center for Organ Recovery and Education
- performs immunofluorescence, and electron microscopic evaluation of renal biopsies.
His principal administrative responsibility is the Quality Assurance review of all renal allograft biopsies, and assignment of coded diagnoses for entry into a computerized database. He serves on the Protocol Review Committee and Data Safety Monitoring Board of the Thomas E. Starzl Institute.
Dr. Randhawa is an expert in native and allograft liver, kidney, heart, pancreas and small intestinal pathology. He evaluates donor organs referred by the Center for Organ Recovery and Education. Immunofluorescence and electron microscopic evaluation are performed in selected cases as dictated by the clinical context.
The clinical profile of patients with BK virus infection in the renal allograft is defined. DNA sequencing of viral strains is being used to define mutations and genomic rearrangements, which may be relevant to the pathogenesis of an extremely refractory interstitial nephritis seen in these individuals. Quantitative PCR assays have been developed to measure viral load in biopsy samples and body fluids to better manage the immunosuppression levels in these patients. The interplay between host and viral immune factors in this disease is being investigated by DNA microarray technology. Drugs with antiviral activity are being screened in an in-vitro culture model for possible future use in the clinical arena.
Anatomic Pathology, Transplantation Pathology, Hepatic Pathology, Renal Pathology
Honors and Awards
- Associate Editor, American Journal of Transplantation (2012) & American Journal of Kidney Diseases (2011)
- Founding Member, American Society of Transplantation, Transplant Diagnostics Community of Practice, 2011
- Mentorship, Stephen Vogel Award, in recognition of an outstanding paper published by a resident or fellow in a journal of the US & Canadian Academy of Pathology, 2010.
- Distinguished Alumnus Award, University of Delhi, 2009.
- Fellowship, National Center for Drug Discovery in Neurodegeneration, Harvard Medical School, 2009
- Mentorship, College of American Pathologists Research, Scholars Grant, 2009
- Chair, Special Emphasis Panel, Urologic & Kid Development & Genitourinary Diseases Study Section, April 2009
- Distinguished Alumnus Award, Maulana Azad Medical College, Delhi University, 2009
- Co-chair, Early Morning Workshop on BK virus, World Transplant Congress, Sydney, August 2008
- Chair, Sunrise Symposium, State of the Art; BK virus and Polyomavirus Allograft Nephropathy, American Transplant Congress, San Francisco, May 2007
- Mentorship Award for Thomas E. Starzl Institute Fellow in Transplantation Biology, 2007
- Fellowship of The American Society of Nephrology, 2004
- Co-chair, Free Communications Session: BKV nephropathy, Am Soc Nephrology Meeting, San Diego, 2003
- Chair: Plenary Session: Viral Infection in Allografts. Banff Congress on Allograft Pathology, Banff, Alberta, 2001
- Member of Editorial Board, Journal of Transplantation, Liver Transplantation, World Journal of Gastroenterologic Oncology, Aegian Journal of Pathology, Indian Journal of Biotechnology
Selected PublicationsView Dr. Randhawa's publications on PubMed
- Kayler L, Mohanka R, Basu A, Shapiro R, Randhawa P. Single versus dual transplantation form donors with significant arteriosclerosis on preimplant biopsy. Clinical Transplantation, 23: 525-31, 2009.
- Randhawa P, Viscidi R., Carter JJ, Galloway D, Culp TD, Huang Y, Ramaswami B, Christensen ND. Identification of Species-specific and Cross Reactive Epitopes in Human Polyomavirus Capsids Using Monoclonal antibodies. J Gen Virol, 2009 Mar; 90(3): 634-639.
- Zeng, G., Bueno, M., Camachos, C.J., Ramaswami, B., Luo, C., and Randhawa, P. Validation of BKV Large T-antigen ATP-Binding Site as a Target for Drug Discovery. Antiviral Res 2009, 81: 184-187.
- Gaurav Gupta, Ron Shapiro, Alin Girnita, Ibrahim Batal, Jerry McCauley, Amit Basu, Henkie Tan, Parmjeet Randhawa. Neutrophilic Tubulitis As A Marker For Urinary Tract Infection In Renal Allograft Biopsies With C4d Deposition. Transplantation, 2009, 87: 1013 -18.
- Batal I, Chalasani G, Wu C, Shapiro R, Bastacky S, and Randhawa P. Deposition of Complement Product C4d in Anti-Glomerular Basement Membrane Glomerulonephritis. Am J Kidney Dis, 53(6):1098-101, 2009.
- Luo C, Bueno M, Kant J, Martinson J, Randhawa P. Genotyping Schemes for Polyomavirus BK using Gene Specific Phylogenetic Trees and SNP Analysis. J Virol. 2009: 83(5): 2285-97.
- Batal, I., Zainah, H., Stockhausen, S., Basu, A., Tan, H., Shapiro, R., Zeevi, A., Girnita, A., and Randhawa, P. The Significance of Renal C4d Deposits in Patients with BK Viruria, Viremia, and Nephropathy. Modern Pathology. 2009: 22: 1468-1476.
- Batal, I., Franco, Z.M., Shapiro, R., Basu. A., Tan,H., Kayler, L., Zeevi, A., Morgan, C., and Randhawa, P. Clinicopathologic analysis of patients with BK viruria and rejection-like graft dysfunction. Human Pathology, 40: 1312-1319, 2009.
- B. Ramaswami, Iulia Popescu, Camila Macedo, Marta Bueno, Diana Metes, Adriana Zeevi, Ron Shapiro, P. Randhawa. HLA-A01, -A03 and -A024 Binding Nanomeric Epitopes in Polyomavirus BK Large T-Antigen. Human Immunology, 70: 722-728, 2009.
- Batal I, Domsic RT, Shafer A, Medsger TA Jr, Kiss LP, Randhawa P, Bastacky S: Renal biopsy findings predicting outcome in scleroderma renal crisis. Hum Pathol. Mar;40(3):332-40, 2009.
- Hirsch HH, Randhawa P. BK virus in solid organ transplant recipients ( American Society of Transplantation Infectious Disease: Practice Guidelines for Polyomavirus BK). Am J Transplantation; 9 (Suppl 4): S132-S142, 2009.
- Randhawa P, Schonder K, Shapiro R, Farasati N, Huang C. Polyomavirus BK Neutralizing Activity in Human Immunoglobulin Preparations. Transplantation. Jun 27;89(12):1462-5, 2010.
- Randhawa PS, Farasati NA, Huang Y, Mapara MY, Shapiro R. Viral drug sensitivity testing using quantitative PCR: effect of tyrosine kinase inhibitors on polyomavirus BK replication. Am J Clin Pathol, 134(6): 916-920, 2010.
- Batal I, Zeevi A, Lunz JG 3rd, Aggarwal N, Shapiro R, Randhawa P, Girnita A. Antihuman leukocyte antigen-specific antibody strength determined by complement-dependent or solid-phase assays can predict positive donor-specific crossmatches. Arch Pathol Lab Med. Oct;134(10):1534-40. 2010.
- Batal I, Lunz JG 3rd, Aggarwal N, Zeevi A, Sasatomi E, Basu A, Tan H. Shapiro R, Randhawa P. A critical appraisal of methods to grade transplant glomerulitis in renal allograft biopsies. Am J Transplant 10: 2442-2452, 2010.
- Momper JD, Zhang S, Randhawa PS, Shapiro R, Schonder KS, Venkataramanan R. Determination of cidofovir in human plasma after low dose drug administration using high-performance liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. Dec 1;53(4):1015-21, 2010.
- Cajaiba M, Parks WT, Fuhrer K, and Randhawa P. Evaluation of human polyomavirus BK as a potential cause of villitis of unknown etiology and spontaneous abortion. J Med Virol, 2011 Jun;83(6):1031-1033.
- Cheng X, Bohl DL, Storch GA, Ryschkewitsch C, Gaudreault-Keener M, Major EO, Randhawa P, Brennan DC. Inhibitory Interactions between BK and JC Virus among Kidney Transplant Patients. J Am Soc Nephrol, May;22(5): 825-831, 2011
- Ramaswami B, Popescu I, Macedo C, Luo C, Shapiro R, Metes D, Chalasani G, Randhawa P. Polyomavirus BK Large T-antigen derived peptide elicits an HLA-DR promiscuous and polyfunctional CD4+ T-cell response. Clinical Vaccine Immunology, May;(5): 815-824, 2011.
- Randhawa P, Kant J, Shapiro R, Tan H, Basu A, Luo C. The Impact of Genomic Sequence Variability on Quantitative PCR Assays for Diagnosis of Polyomavirus BK Infection. J Clin Microbiol, Dec;49(12):4072-76, 2011.
- Batal I, Azzi J, El-Haddad N, Riella LV, Lunz III JG, Zeevi A, Sasatomi E, Basu A, Tan H, Shapiro R, and Randhawa P. Immunohistochemical Markers of Tissue Injury in Biopsies with Transplant Glomerulitis. Human Pathology, Jan;43(1):69-80, 2012.
- Luo C, Hirsch H, Kant J, Randhawa P. VP-1 Quasispecies in Human Infection with Polyomavirus BK. J Med Virol, Jan;84(1): 152-61, 2012.
- Masutani K, Shapiro R, Basu A, Tan H, Wikjstrom M, Randhawa P. The Banff 2009 Working Proposal for Polyomavirus Nephropathy: a critical evaluation of its utility as a determinant of clinical outcome. Am J Transplant, 2012 Apr;12(4):907-18.
- Masutani K, McMichael J, Donaldson J, Shapiro R, Basu A, Tan H, Ninomiya T, and Randhawa P. Putative episodes of T-cell mediated rejection in patients with sustained BK viruria but no viremia. Transplantation, 94: 43-49, 2012.
- Pastrana DV, Brennan DC, Cuburu N, Storch GA, Viscidi RP, Randhawa PS, Buck CB. Neutralizing serotyping of BK polyomavirus infection in kidney transplant recipients. PLoS Pathogens, 8: e1002650, 2012.
- Randhawa P, Mannon RB. A case of late kidney allograft failure. A clinico-pathologic conference from American Society of Nephrology Kidney Week 2011. Clin J Am Soc Nephrol, 2012, 11: 1884-89.
- Randhawa PS and Borislav A. Alexiev (equal contribution authors, Gang Zeng, Chunquing Luo, Eduardo Vazquez Martul,Cinthia B. Drachenberg,and John C. Papadimitriou. BK Virus Associated Urinary Bladder Carcinoma in Transplant Recipients: Proposed pathogenetic model. Human Pathology. 44: 908-917, 2013.
- Mengel M, Samantha Chan, Jessie Climenhaga, Yael B Kushner, Heinz Regele, Robert B Colvin, Randhawa PS. Banff Initiative For Quality Assurance in Transplantation (BIFQUIT):Reproducibility assessment for C4d immunohistochemistry in kidney allografts. Am J Transplant, 13: 1235-45, 2013.