Joseph Locker, MD, PhD
Professor of Pathology
Dr. Locker is a member of the Division of Molecular Anatomic Pathology.
BST South S421
200 Lothrop Street
Pittsburgh, PA 15261
Office Telephone: 412-648-9701
Lab Telephone: 412-648-9656
- PhD - University of Chicago, 1974
- MD - University of Chicago, 1975
Clinical ExpertiseAnatomic Pathology, Cancer Molecular Diagnostics.
Research InterestsTranscription factors; Gene expression; Molecular Genetics; Liver development, disease, and cancer; Lung development, stem cells, and cancer; Tumor progression; Cancer cell biology.
Selected PublicationsView Dr. Locker's publications on PubMed
Friedl P, Locker J, Sahai E, Segall, JE (2012) Classifying collective cancer cell invasion. Nature Cell Biol 14, 777 - 783.
Bhattacharyya S, Tian J, Locker J. (2011) Analysis of albumin gene long-range transcription controls by targeted chromosomal integration. PLoS One 6, e23234.
Tian J, Huang H, Liebermann D, Ledda-Columbano GM, Columbano A, Locker J. (2011) Gadd45 is an inducible coactivator of transcription that facilitates rapid liver growth. J Clin Invest 121, 4491-4502.
Harris T, Pan Q, Sironi S, Lutz D, Tian J, Sapkar J, Perez-Soler R, Keller S, Locker J. (2011) Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. Clin Cancer Res 17, 690-9.
Tian J, Mahmood R, Hnasko R, Locker J. (2006) Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia. Cancer Res 66, 10399-407.
Kajiyama Y, Tian J, Locker J. (2006) Organization of distant enhancers and their promote interactions are independent of repression. J. Biol. Chem. 281, 30122-31.
Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J. (2005) Gadd45? is induced through a CAR-dependent TNF-independent pathway in liver hyperplasia. Hepatology 42, 1118-26
Locker J, Tian J, Carver R, Concas D, Cossu C, Ledda-Columbano GM, Columbano A. (2003) A common set of immediate-early response genes in liver regeneration and hyperplasia. Hepatology 38, 314-25.
Locker J, Ghosh D, Luc PV, Zheng J. (2002) Definition and prediction of the full range transcription factor binding sites - the Hepatocyte Nuclear Factor 1 dimeric site. Nucleic Acids Res. 30, 3809-17.
Apergis G, Crawford N, Ghosh D, Steppan C, Vorachek WR, Locker J. (1998) A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma, J Biol Chem 273, 2917-25.