Ronald Jaffe, MB, BCh
Professor of Pathology

Dr. Jaffe
Dr. Jaffe is a member of the Division of Pediatric Pathology.

Office Location:
Department of Pathology
Children's Hosptial of Pittsburgh
4401 Penn Avenue
Pittsburgh PA 15224

Contact Information:
Office Telephone: 412-692-5657
Fax: 412-692-6550


  • BSc - 1965, University of Witwatersrand, Johannesburg
  • MB, BCh - 1969, University of Witwatersrand, Johannesburg

Clinical Expertise

Diagnostic general pediatric pathology with a special interest in:
  • Childhood histiocytoses
  • Childhood liver disease
  • Pediatric transplantation pathology

Research Interests

  • The histiocytic disorders of childhood, Langerhans cell histiocytosis, juvenile xanthogranuloma, Rosai-Dorfman disease and the hemophagocytic lympho-histiocytoses
  • Pediatric transplantation pathology, liver and intestine, post-transplant lymphoproliferative disorders
  • Pediatric liver diseases, cholestatic and metabolic


  • PA MD # 019729-E
  • ABP Anatomic Pathology 1978, Pediatric Pathology 1990


  • Society for Pediatric Pathology
  • US Canadian Academy of Pathology (USCAP)
  • Hematopathology Society
  • Histiocyte Society

Selected Publications

View Dr. Jaffe's publications on PubMed

Zwerdling T, Won E, Shane L, Javahara R, Jaffe R. Langerhans cell sarcoma: case report and review of world literature. J Pediatr Hematol Oncol 2014;36:419-25.

Wartchow EP, Jaffe R, Mierau GW. Ciliary Inclusion Disease. Report of a new PCD variant. Pediatr Dev Pathol2014;17:465-69.

Picarsic J, Egeler RM, Chikwava K, Patterson K, Jaffe R. Histologic patterns of thymic involvement in Langerhans cell proliferations: A clinicopathologic study and review of the literature. Pediatr Dev Pathol 2015;18:127-138.

Jaffe R, Chikwava K. Disorders of Histiocytes. In: Hematopathology, Hsi ED ed. 2nd ed. Elsevier, Saunders, Philadelphia 2012, 549-587.

Jaffe R. Langerhans cell histiocytosis and Langerhans cell sarcoma. In: Hematopathology, eds Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber DA. Saunders/Elsevier, Philadelphia PA, 2011: 811-826.

Jaffe R. Histiocytic Proliferations in Childhood. In: Diagnostic Pediatric Hematopathology, Ed. M. Proytcheva, Cambridge University Press, Cambridge 2011:504-539.

Weitzman S, Jaffe R. Uncommon histiocytic disorders; The non-Langerhans Cell Histiocytoses. Pediatr Blood & Cancer 2005;44:1-9.

Costa da Cunha Castro E, Blazquez C, Boyd J, Correa H, de Chaderevian JP, Felgar RE, Graf N, Levy N, Lowe EJ, Manning Jr JT, Proytcheva M, Senger C, Shayan K, Sterba J, Werner A, Surti U, Jaffe R. Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature. Pediatr & Dev Pathol 2010;13:225-237.

Vakkila J, Jaffe R, Michelow M, Lotze M. Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors. Clin Cancer Res 2006;12:2049-2054.

Chikwava KR, Hunt JL, Mantha GS, Murphy JE, Jaffe R. Analysis of loss of heterozygosity in single system and multisystem Langerhans’ cell histiocytosis. Pediatr Dev Pathol 2007;10:18-24.

Bechan GI, Meeker AK, DeMarzo AM, Racke F, Jaffe R, Sugar E, Arceci R. Telomere length shortening in Langerhans cell histiocytosis. Br J Haematol. 2008;140:420-428.