Ronald Jaffe, MB, BCh
Professor of Pathology
Dr. Jaffe is a member of the Division of Pediatric Pathology.
Department of Pathology
Children's Hosptial of Pittsburgh
4401 Penn Avenue
Pittsburgh PA 15224
Office Telephone: 412-692-5657
- BSc - 1965, University of Witwatersrand, Johannesburg
- MB, BCh - 1969, University of Witwatersrand, Johannesburg
Clinical ExpertiseDiagnostic general pediatric pathology with a special interest in:
- Childhood histiocytoses
- Childhood liver disease
- Pediatric transplantation pathology
Dr. Jaffe's main interest is in the nature and biology of the childhood histiocytoses and the diagnostic pathology of disorders of macrophages and dendritic cells. Fetal and placental macrophages will be added to the mix.
Objectives: to categorize, phenotype and study examples of these rare conditions, correlate with clinical behavior in order to understand the natural history and to derive logical therapies.
A wide network of affiliations, most importantly the Histiocyte Society and the American Histiocytosis Association provide a stream of diagnostic consults that provide the clinical material. The phenotyping is done in the Division, using a panel of macrophage and dendritic-cell markers. A large repository of over 250 cases of Non-Langerhans cell lesions and the same number of Langerhans cell lesions (LCH) is available as a searchable database and matching slides and has been used by Hematopathology Fellows. In the past few years this has formed the basis for chapters on diseases of histiocytes in hematopathology reference texts as well as authorship of the relevant sections of the WHO Classification of Tumors of Haematopoietic and Lymphoid tissues, 2008 and WHO Classification of Tumours of Soft Tissue and Bone, 2013.
Recent work with a Pediatric Pathology fellow documented greater loss of heterozygosity in multisystem versus single system LCH, a model for progressive cancer-type development, and this was followed by demonstration of telomere length shortening in LCH with a group from Johns Hopkins that extends this theme. The collection, collation and investigations are ongoing. A recent research fellow, Eumenia Castro, published a collection of 20 examples of Atypical Histiocytic lesions that followed Acute Lymphoblastic Leukemia some of which share the same molecular markers as the leukemia.
As a result of Dr. Jaffe's on-going interest in liver diseases of childhood, he is a working member of the Cholestatic Liver Diseases of Infancy Consortium. This involves acquiring tissues and slides, and national review of contributed slides with the aim of standardizing diagnostic criteria and broadening the pathologic criteria in accordance with molecular genetic information. A similar group to review Sclerosing Cholangitis Childhood (STOPC) is in the process of being formed. Dr. Jaffe has an interest in liver transplant pathology and collaborate with the Pediatric Transplant Division on a number of projects.
- PA MD # 019729-E
- ABP Anatomic Pathology 1978, Pediatric Pathology 1990
- Society for Pediatric Pathology 1975-
- Histiocyte Society 1983-
- Society for Hematopathology 1981-
- U.S. Canadian Academy of Pathology 1977-
- Children's Oncology Group 1977-
Honors and Awards
Life Member, Nikolas Symposium for the Histiocytoses, Loutraki, Greece
Selected PublicationsView Dr. Jaffe's publications on PubMed
- Picarsic J, Egeler RM, Chikwava K, Patterson K, Jaffe R, Histologic patterns of thymic involvement in Langerhans cell proliferations. A clinicopathologic study and review of the literature. Pediatr Dev Pathol 2015;18:127-138. PMID: 25629953.
- Mazor RD, Manevich-Mazor M, Kesler A, Aizenstein O, Eshed I, Jaffe R, Pessach Y, Goldberg I, Sprecher E, Yaish I, Gurai A, Ganzel C, Shoenfeld Y. Clinical considerations and key issues in the management of patients with Erdheim-Chester disease: a seven case series. BMC Medicine 2014;12:221. PMID: 225434739.
- Chikwava K, Jaffe R. Paediatric histiocytic tumors: Diagnostic Histopathology 2014;20:56-66.
- Zwerdling T, Won E, Shane L, Javahara R, Jaffe R. Langerhans cell sarcoma: case report and review of world literature. J Pediatr Hematol Oncol 2014;36:419-25. PMID: 24942035.
- Heath JL, Burgett SE, Gaca AM, Jaffe R, Wechsler DS. Successful treatment of pediatric histiocytic sarcoma using abbreviated high-risk leukemia chemotherapy. Pediatr Blood Cancer 2014;61:1874-6. PMID: 24888336
- Akilov OE, Desai N, Jaffe R, Gehris RP. Bullous Sweet's syndrome after granulocyte colony-stimulating factor therapy in a child with congenital neutropenia. Pediatr Dermatol 2014;31:e61-62. PMID: 24387761
- Chen W, Jaffe R, Zhang L, Hill C, Block AM, Sait S, Song B, Liu Y, Cai D. Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: lineage analysis and BRAF V600E mutation study. N Am J Med Sci 2013;5:386-391 PMID: 23923114
- Gheorghe G, Radu O, Milanovich S, Hamilton RL, Jaffe R, Southern JF, Ozolek JA. Pathology of central nervous system postransplant lymphoproliferative disorders: lessons from pediatric autopsies. Pediatr Dev Pathol 2013;16:67-73. PMID: 23286282