Molecular Diagnostics -- Abdominal Pain


MOLECULAR DIAGNOSTICS:

INTERPRETATION:

B-cell lymphoma without Bcl-2 gene rearrangement.

RESULTS:

TESTS:

Immunoglobulin heavy chain rearrangement
Bcl-2 gene rearrangement
DNA purification

RESULTS:

The heavy chain gene shows 2 bands of clonal gene
rearrangement. The Bcl-2 gene is normal at the mbr and mcr loci.

COMMENTS:

The lesion probably contains a single clone of
neoplastic B-cells with diallelic gene rearrangement. The clonal
B-cells comprise the majority of cells in the tissue specimen.
The absence of Bcl-2 gene rearrangement indicates that this
marker cannot be used for the assessment of dissemination or
residual disease.


FINAL DIAGNOSIS


Case 

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