Microscopic Description -- Fevers, Cutaneous Nodules and Cerebrovascular Accident


Sections of the brain showed infiltration of the parenchyma by fungal organisms (Image 04) multifocal hemorrhagic infarcts (Image 05), and invasion of vessels by fungal organisms (Image 06). A Grocott stain outlined the abundant septate fungal hyphae, with occasional acute angle branching and numerous swollen hyphal segments (Image 07). Sections of the myocardium revealed multiple areas of extensive necrosis, mild chronic inflammation, and abundant fungal organisms (Image 08). Occasional vessels showed fungal thrombi (Image 09). Sections of the pancreas demonstrated a small area of necrosis and fungal proliferation (Image 10). Sections of the spleen revealed foci of necrosis with fungal proliferation (Image 11). Sections of the kidneys showed multiple foci of necrosis, mild chronic inflammation, hemorrhage, fibrin exudation and fungal organisms (Image 12 and 13). Sections of the thyroid demonstrated areas of necrosis, with hemorrhage, karyorrhectic debris, fibrin exudation and abundant fungal forms (Image 14 and 15).


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