Microscopic Description -- A Right Testicular Mass


H & E sections demonstrate a pubertal testis with active spermatogenesis and spermiogenesis. There are multiple nodules of large pale cells occurring in small clusters with prominent central calcification (Figures 4, 5 and 6). The neoplastic cells are large and round with abundant finely granular eosinophilic cytoplasm (Figure 7). The nuclei are round to oval and bland with small nucleoli (Figure 8). Mitoses are rare. No necrosis or lymphovascular invasion is seen. Several of the tumor nodules are surrounded by a moderately intense lymphocytic infiltrate (Figure 6). A patchy neutrophilic infiltrate is seen within some of the nodules (Figures 9 and 10). The neoplastic cells stain positive with S100 (Figure 11). In addition, there is a prominent Leydig cell hyperplasia in the interstitium between unremarkable seminiferous tubules (Figure 12). The spermatic cord is unremarkable. No tumor is seen outside the testis.


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