Final Diagnosis -- Chronic Lymphocytic Interstitial Nephritis, Non-Hodgkin's Lymphoma, B-Cell Type



The biopsy shows a lymphomatous infiltrate involving the perirenal soft tissues and renal capsule, a diagnosis supported by the immunophenotype of the lymphocytes marking as B-cells of follicular center cell origin.

On the other hand, the renal parenchyma shows a chronic interstitial nephritis with the Lymphocytic infiltrate marking predominantly as T-cells rather than B-cells; parenchymal chronicity changes are moderately severe. It is likely that the patient has two concurrent processes, ie lymphomatous perirenal infiltrate and chronic interstitial nephritis, the latter possibly related to chronic NSAID use.

Electron microscopy is not performed on this biopsy, since there is no evidence to suggest a concurrent glomerular process.



  1. Bertoncelli C etal. Parenchymal renal involvement in three cases of Non-Hodgkin Lymphomas:Clinical and Pathological features.Haematologica 1993;78:58-60.
  2. Charasse C etal. Non-Hodgkin's Lymphoma presenting as Acute Renal Failure:A new case. Nephron 1996; 73:350-351.
  3. Hemal A.K,Sharma S.K. Urological Complications of Advanced Lymphoma.Urol Int 1994;52:77-81.
  4. Miyake o etal. Secondary Involvement of Genitourinary Organs in Malignant Lymphoma.Urol Int 1987;42:360 -362.

Contributed by Swaminathan Rajendiran,MD and Sheldon Bastacky, MD

Case IndexCME Case StudiesFeedbackHome