Final Diagnosis -- Cirrhosis (Hepatitis C)

FINAL DIAGNOSIS:

PART 1: NATIVE LIVER (1500 GRAMS), ORTHOTOPIC LIVER

TRANSPLANTATION -

A. ADVANCED CIRRHOSIS WITH MIXED MACRONODULAR AND

MICRONODULAR PATTERNS AND MODERATE CHOLESTASIS.

B. MILD MACROVESICULAR STEATOSIS AND EVIDENCE OF

STEATOHEPATITIS.

C. INFARCTED MACROREGENERATIVE NODULE (deeper levels

and reticulin stain to follow).

D. S/P CHOLECYSTECTOMY.

PART 2: ALLOGRAFT LIVER, POST-PERFUSION NEEDLE BIOPSY -

A. CHANGES OF MILD PRESERVATION/ISCHEMIC INJURY.

B. NO CONFLUENT NECROSIS SEEN.

The cirrhosis is at an advanced stage and the histologic features are consistent with the clinical history of chronic Hepatitis C infection. Additional morphologic changes raise the possibility of concurrent steatohepatitis; this should be evaluated clinically as an etiologic factor.

ADDENDUM #3 (1 Reticulin) The reticulin stain demonstrates focal absence of the reticulin fibers. Again, no evidence of malignancy is seen.

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