Maren Y. Fuller, MD and Miguel Reyes-Mugica, MD
A term female neonate presented for excision of two prenatally detected oral cavity masses. The pregnancy was uncomplicated, and the neonate was delivered via Caesarean section without complications. Immediately following delivery, the patient was transferred to the operating room. Intra-operative findings included a 1 cm mass of the ventral tongue and a 4 cm mass of the left maxillary alveolar ridge, both of which were excised. At time of discharge, she was feeding orally without issue and was stable on room air.
Two specimens were received fresh in the pathology laboratory. Part 1 was designated "tongue mass" and was a 1.2 x 1.2 x 0.7 cm portion of soft tissue with a fleshy, tan-pink cut surface. Part 2 was designated "maxillary alveolar mass" and was a 5.0 x 3.3 x 2.7 cm soft tissue mass with a homogenous tan-pink to tan-white cut surface with focal calcification and hemorrhage.
Sections of both specimens showed atrophic squamous epithelium overlying a proliferation of large polygonal cells with well-defined cell borders and abundant eosinophilic, granular cytoplasm. The nuclei are small with dense chromatin and inconspicuous nucleoli. In the deeper aspect of part 2, there is a component with more spindled cells and a mild to moderate lymphocytic infiltrate. No significant atypia, pleomorphism, or mitotic activity was noted.
Immunohistochemical stains were performed with appropriate controls with the following findings:
The karyotype showed apparently normal female chromosome analysis (46,XX).