Contributed by Rosemary A Recavarren, MD, Robert Schoen, MD, and Antonia R. Sepulveda, MD, PhD
Published on line in June 2005
The patient is a 30 year-old female with history of familial polyposis, status post transanal excision of rectal villous adenoma, and restorative proctocolectomy with ileoanal anastomosis and loop ileostomy for colonic polyposis. An upper gastrointestinal endoscopy was performed and demonstrated multiple gastric polyps in the fundus and body (Figure 1A and B). Representative biopsies from the gastric polyps were submitted for pathological examination.
The specimen was identified as "gastric polyps" and consisted of three smooth rubbery tan gray tissue fragments ranging from 0.2 to 0.3 cm in greatest dimension. The specimen was entirely submitted.
Figures 1A and 1B: Endoscopic examination of the stomach revealed numerous small polyps with a smooth surface, in the stomach fundus and body.
Figures 2A and 2B: Hematoxylin and Eosin stain of stomach gland polyp. Original magnification 100X (2A) and 200X (2B).
Figure 3: Immunohistochemical stain for Ki-67 of stomach gland polyp. Original magnification 200X. The Ki-67-positive nuclei are stained brown.
Figures 4A and 4B: Immunohistochemical stain for beta-catenin of stomach gland polyp. Original magnification 400X. The positive stain is brown.