Yingze Zhang, PhD
Professor of Medicine and Human Genetics

Dr. Zhang is an Associate Professor of Medicine and Human Genetics; Director, Translational Research Core Laboratory; Director, Cardiology Biobank

Office Location:
UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-624-7225
Email: zhangy@upmc.edu

Research Interests

Dr. Zhang's current research is focused on the molecular and genetic basis of pulmonary and vascular diseases including COPD, ILD, sickle cell and systemic complications associated with these diseases. She is also actively working on the discovery and validation of prognostic and diagnostic biomarkers related to lung and vascular diseases. In addition, her laboratory is actively investigating the functional significance of disease associated genetic variants and their roles in disease pathogenesis. Dr. Zhang also directs the translational core lab for the Division of Pulmonary, Allergy and Critical Care Medicine and the Biobank for Cardiology and Vascular Medicine Institute. She has been PI or co-I on multiple grants funded by NIH and other agencies. She has published over 120 peer-reviewed manuscripts.

Selected Publications

  1. Li X, Kim S, Chen TY, Wang J, Yang X, Tabib T, Tan J, Guo B, Fund S, Zhao J, Sembrat J, Rojas M, Shiva S, Lafyatis R, St. Croix C, Alder JK, Di YP, Kass DJ, Zhang Y. Toll Interacting Protein Protects Bronchial Epithelial Cells from Bleomycin-Induced Apoptosis 2020. Faseb J (Accepted)
  2. Chen TY, Li X, Hung CH, Bahudhanapati H, Tan J, Kass DJ, Zhang Y. The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease. Mol Genet Genomic Med. 2020 Feb 26:e1194. doi: 10.1002/mgg3.1194. [Epub ahead of print] Review. PMID: 32100955.
  3. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 Oct 30;11(516). pii: eaau6296. doi: 10.1126/scitranslmed.aau6296. PMID: 31666402
  4. Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK. GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 21. doi: 10.1152/ajplung.00062.2019. [Epub ahead of print]. PMID: 31432710
  5. Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD. Extreme Trait Whole Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med. 2017; 196(2): 159-71.
  6. Noth, I, Zhang, Y, Ma, S-F, Flores, C, Barber, M, Huang, Y, Broderick, SM, Wade, MS, Hysi, P, Sciurba, J, Richards, TJ, Juan-Guardela, BM, Vij, R, han, MK, Martinez, FJ, Kossen, K, Seiwert, SD, Christie, JD, Nicolae, D, ...et all. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. LANCET Respiratory Medicine. 2013; Jun;1(4): 309-17. PMID: 24429156; PMCID: PMC3894577
  7. Peljto, AL, Zhang, Y, Fingerlin, TE, Ma, SF, Garcia, JG, Richards, TJ, Silveira, LJ, Lindell, KO, Steele, MP, Loyd, JE, Gibson, KF, Seibold, MA, Brown, KK, Talbert, JL, Markin, C, Kossen, K, Seiwert SD, Murphy, E, Noth, I, ...et all. Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis. JAMA. 2013; Jun 5;309(21): 2232-9. PMID: 23695349; PMCID: PMC4545271.
  8. Richards, T, Park, C, Chen, Y, Gibson, KF, Di, YP, Pardo, A, Watkins, SC, Choi, AMK, Selman, M, Pilewski, J, Kaminski, N, Zhang, Y. Allele Specific Transactivation of Matrix Metalloproteinase 7 by FOXA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis. AJP Lung. 2012; AJP Lung 2012. 302 (8):L746-54. PMID: 22268124; PMCID: PMC3331579.
  9. Richards, T, Kaminski, N, Baribaud, F, Flavin, S, Brodmerkel, C, Horowitz, D, Li, K, Choi, J, Vuga, L, Lindell, K, Klesen, M, Zhang, Y, Gibson, K. Peripheral blood proteins predict mortality in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2012; Jan 1;185(1): 67-76. PMCID: PMC3262037.
  10. Zhang, Y, Noth, I, Garcia, JGN, Kaminski, N. A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med. 2011; 364: 1576-7. PMID: 21506748; PMCID: PMC4327994.