Vijay K. Yechoor, MD
Professor of Medicine

Dr. Yechoor
Dr. Yechoor is Director, Diabetes and Beta Cell Biology Center, Diabetes and Metabolic Bone Disease Endowed Chair, Division of Endocrinology and Metabolism.

Office Location:
W1058 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213

Contact Information:
Office Telephone: 412-383-4251

Research Interests

Dr. Yechoor's research program focuses on developing targeted therapies that target beta cell mass and function in the pathogenesis of diabetes. He has a long record of external funding from the National Institutes of Health, the Veterans Administration, Juvenile Diabetes Research Foundation, and the American Diabetes Association. His currently funded projects include 1) the role of the circadian clock in beta cell stress adaptation, and 2) the role of Tead1 in the transcriptional regulation of quiescence and proliferation of beta cells. More recently, he has extended his research into adipose tissue and cardiac muscle biology.

Selected Publications

  • Aslanoglou, D., Bertera, S., Sßnchez-Soto, M., Benjamin Free, R., Lee, J., Zong, W., Xue, X., Zong, W., Brissova, M., Logan, R.W., Wollheim, C.B., Trucco, M., Yechoor, V.K., Sibley, D.R., Bottino, R., Freyburg, Z. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Transl Psychiatry. 2021; 11(1): 59.
  • Xiong, X., Lin, Y., Lee, J., Paul, A., Yechoor, V., Figueiro, M., Ma, K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2021; 521: 111110.
  • Liu, R., Xiong, X., Nam, D., Yechoor, V., Ma, K. SRF-MRTF signaling suppresses brown adipocyte development by modulating TGF-▀/BMP pathway. Mol Cell Endocrinol. 2020; 515: 110920.
  • Liu, R., Jagannathan, R., Sun, L., Li, F., Yang, P., Lee, J., Negi, V., Perez-Garcia, E.M., Shiva, S., Yechoor, V.K., Moulik, M. Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2020; 319(1): H89-99.
  • Yin, H., Li, W., Chatterjee, S., Xiong, X., Saha, P., Yechoor, V., Ma, K. Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation. FASEB J. 2020; 34(5): 6613-6627.
  • Liu, H., Zhang, C.H., Ammanamanchi, N., Suresh, S., Lewarchik, C., Rao, K., Uys, G.M., Han, L., Abrial, M., Yimlamai, D., Ganapathy, B., Guillermier, C., Chen, N., Khaladkar, M., Spaethling, J., Eberwine, J.H., Kim, J., Walsh, S., Choudhury, S., et al. Control of cytokinesis by ▀-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019; 11(512).
  • Chatterjee, S., Yin, H., Li, W., Lee, J., Yechoor, V.K., Ma, K. The Nuclear Receptor and Clock Repressor Rev-erba Suppresses Myogenesis. Sci Rep. 2019; 9(1): 4585.
  • Liu, R., Jagannathan, R., Li, F., Lee, J., Balasubramanyam, N., Kim, B.S., Yang, P., Yechoor, V.K., Moulik, M. Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2): e0212017.
  • Lee, J., Ma, K., Moulik, M., Yechoor, V. Untimely oxidative stress in ▀-cells leads to diabetes - Role of circadian clock in ▀-cell function. Free Radic Biol Me. 2018; 119: 69-74.
  • Gao, H., Ho, E., Balakrishnan, M., Yechoor, V., Yallampalli, C. Decreased insulin secretion in pregnant rats fed a low protein diet. Biol Reprod. 2017; 97(4): 627-635.