Satdarshan (Paul) Singh Monga, MD
Professor of Pathology
Professor in Experimental Pathology


Dr. Monga is the Chair for Experimental Pathology, Vice Chair and Chief of Division of Experimental Pathology, Professor of Pathology (Division of Experimental Pathology), Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition), Assistant Dean for Medical Scientist Training Program, Director of Cellular Approaches to Tissue Engineering & Regeneration (CATER) Program, and Director of the Pittsburgh Liver Research Center.

Office Location:
S-422 BST
200 Lothrop Street
Pittsburgh PA 15261
Contact Information:
Office Telephone: 412-648-8842
Email: smonga@pitt.edu
or mongass@upmc.edu

Education

  • MD - Dayanand Medical College & Hospital, Ludhiana, India, 1993
  • Postdoctoral Fellowship - Georgetown University, 1997
  • Postdoctoral Fellowship - Temple University, 1999

Research Expertise

For around 21 years, my research has focused on understanding the cellular and molecular basis of liver health and disease. Specifically, my lab has a longstanding interest in understanding the role of cellular and molecular signaling in liver development, regeneration, inflammation, injury, fibrosis and tumorigenesis. Being in the field for around 20 years, we have generated many novel and innovative tools to study liver. Using GEMM models, AAV systems, lipid nanoparticles, imaging modalities and others, we have been able to identify role of pathways such as Wnt, HGF, PDGF, Yap and others in both hepatic physiology and pathology. The eventual goal of the lab is to gain better understanding of molecular aberrations for improved therapeutics for various hepatic diseases such as end stage liver disease (ESLD), liver failure, injury, fibrosis and cancer. The eventual goal of the lab is to gain better understanding of molecular aberrations in various hepatic diseases for improved clinical outcomes. One major focus of the lab is to understand subsets of human HCC through better and more representative disease modeling. The starting point of the investigation is human HCC analysis to identify novel combinatorial aberrations in the form of mutations and/or expression changes in specific genes. Such combinations are then expressed through innovative technology in a subset of hepatocytes in mice. Appearance of HCC supports the oncogenic nature of the co-occurrences and concordance between gene expression from human HCC subset with such co-occurrences and HCC in mice generated through expression of these co-occurrences supports validity of the model in recapitulating human disease. We then use such models to study HCC pathogenesis in that subset to address tumor biology, progression and therapeutics for translation into patients. This is an interesting approach from bedside to bench and back. Because of liver's regenerative potential, there are innovative opportunities to develop therapies for ESLD. Ongoing research is focusing on innovations in surgery, stem cell biology, cellular reprogramming, cell therapy, and hepatic tissue engineering, broadly categorized under the Hepatic Regenerative Medicine. Our lab has focused on elucidating role and regulation of complex cell-molecule circuitry of the highly relevant pathways such as Wnt/ β-catenin in liver physiology especially in metabolic zonation and regeneration, which we believe will be prudent for the continued success of hepatic regenerative medicine as a discipline and expected to yield better therapies for patients with chronic liver disease, cirrhosis and ESLD.

NIH Research

View Dr. Monga's NIH RePORT on nih.gov

Selected Publications

View Dr. Monga's publications on PubMed

  • Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is Protective during Kidney Ischemia-Reperfusion Injury. Am J Physiol Renal Physiol. 2015 Apr 29:ajprenal.00066.2015.
  • Jing Yang, Antonella Cussimano, Jappmann Monga, Morgan Preziosi, Filippo Pullara, Guillerma Calero, Richard Lang, Terry Yamaguchi, Kari Nichole Nejak-Bowen, Monga SP. Wnt5a inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration. American Journal of Pathology. 2015 (In Press).
  • Delgado A, Okabe H, Preziosi M, Russell JO, Alvarado TF, Oertel M, Nejak-Bowen KN, Zhang Y, Monga SP. Complete response of Ctnnb1-mutated tumors to β-catenin suppression by locked nucleic antisense in mouse hepatocarcinogenesis model. Journal of Hepatology. J Hepatol. 2015 Feb;62(2):380-7. Accompanying Editorial.
  • Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, Monga SP, Apte U. Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model. Am J Pathol. 2014 Sep 2. pii: S0002-9440(14)00437-4. doi: 10.1016/j.ajpath.2014.07.019.
  • Hirohisa Okabe, Evan Delgado, Jung Min Lee, Jing Yang, Hiroki Kinoshita, Hiromitsu Hayashi, Allan Tsung, Jaideep Behari, Toru Beppu, Hideo Baba, Monga SP. Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLOS ONE 2014 Jun 3;9(6):e98817.
  • Junyan Tao, Diego F. Calvisi, Sarangarajan Ranganathan, Antonio Cigliano, Lili Zhou, Sucha Singh, Lijie Jiang, Biao Fan, Luigi Terracciano, Sorin Armeanu-Ebinger, Silvia Ribback, Frank Dombrowski, Matthias Evert, Xin Chen, Monga SP. Wnt/β-catenin and Yap pathways synergize to promote hepatoblastoma development in mice and men. Gastroenterology, 2014 May 14. pii: S0016-5085(14)00610-6.
  • Evan Delgado, Jing Yang, Juhoon So, Stephanie Leimgruber, Michael Kahn, Tohru Ishitani, Donghun Shin, Gabriela Mustata Wilson, Monga SP. Identification and characterization of a novel small molecule inhibitor of beta-catenin signaling. American Journal of Pathology, 2014 May 9. (In Press).
  • Jing Yang, Laura E. Mowry, Kari Nichole Nejak-Bowen, Hirohisa Okabe, Cassandra R. Diegel, Richard A. Lang, Bart O. Williams, Monga SP. Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation. Hepatology 2014 Feb 20.
  • Fanti M, Singh S, Ledda-Columbano GM, Columbano M, Monga SP. Triiodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents. Hepatology 2013, Oct. 07.
  • Lee JM, Yang J, Newell PN, Singh S, Parwani A, Friedman SL, Nejak-Bowen KN, Monga SP. Beta-catenin signaling in hepatocellular cancer. Implications in inflammation, fibrosis and proliferation. Cancer Letters, 2013, Sep. 23.
  • Delgado E, Bahal R, Yang J, Lee JM, Ly DH, Monga SP. β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid. Curr Cancer Drug Targets. 2013 Oct;13(8):867-78
  • Criscimanna A, Duan D, Rhodes JA, Fendrich V, Wickline ED, Hartman DJ, Monga SP, Lotze M, Gittes GK, Fong GH, Esni F. PanIN-specific regulation of Wnt signaling by HIF2. Cancer Res. 2013 Aug 1;73(15):4781-90.
  • Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SP, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME. Activation of the Transcription Factor GLI1 by WNT Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration. J Biol Chem. 2013 Jul 19;288(29):21389-98.
  • Wickline E, Du Y, Stolz DB, Kahn M, Monga SP. β-Catenin at adherens junctions: Mechanism and biological implications in hepatocellular cancer after β-catenin knockdown. Neoplasia. 2013 Apr;15(4):421-34.
  • Awuah P, Nejak-Bowen KN, Monga SP. Role and regulation of PDGFRα in liver development and regeneration. Am J Pathol. 2013 May;182(5):1648-58
  • Pullara F, Guerrero-Santoro J, Calero M, Zhang Q, Peng Y, Spahr H, Kornberg GL, Cusimano A, Stevenson HP, Santamaria H, Reynolds SL, Brown IS, Monga SP, Houten BV, Rapic-Otrin V, Calero G, Levine AS. A general path for large-scale solubilization of cellular proteins: From membrane receptors to multiprotein complexes. Protein Expr Purif. 2013 Feb;87(2):111-9.
  • Nejak-Bowen KN, Kikuchi A, Monga SP. β-Catenin-NF-κB interactions in murine hepatocytes: A complex to die for. Hepatology 2013 Feb;57(2):763-74.