Yu-Chih Chen, PhD
Assistant Professor

Dr. Chen is an Assistant Professor, UPMC Hillman Cancer Center, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh.

Office Location:
5115 Centre Avenue
Pittsburgh, PA 15232

Contact Information:
Office Telephone: 412-623-7701
Email: cheny25@upmc.edu

Research Interests

Due to genomic and epigenetic instability of cancer cells, inter-patient and intra-patient heterogeneity in tumors creates formidable challenges in identifying optimal treatments. To address the challenges, we aim to establish comprehensive high-throughput multi-omics single-cell analysis including genome, epigenome, transcriptome, proteome, functional, and morphological methods. With large amounts of data collected from high-throughput single-cell multi-omics analysis, machine learning techniques can predict patient prognosis and suggest treatments for precision medicine. The integrated approach will change how we understand and treat cancer and ultimately improve outcomes for patients. Lab Website: https://www.ycchenlab.org/

Selected Publications

  • Yu-Chih Chen*, Hyoung Won Baac*, Kyu-Tae Lee, Shamileh Fouladdel, Kendall Teichert, Jong G. Ok, Yu-Heng Cheng, Patrick N. Ingram, A. John Hart, Ebrahim Azizi, L. Jay Guo, Max S. Wicha, and Euisik Yoon, "Selective photo-mechanical detachment and retrieval of divided sister cells from enclosed microfluidics for downstream analyses," ACS Nano, 11 (5), 4660-4668, 2017.
  • Yu-Chih Chen*, Maria E. Gonzalez*, Boris Burman, Xintao Zhao, Talha Anwar, Mai Tran, Natasha Medhora, Ayse B. Hiziroglu, Woncheol Lee, Yu-Heng Cheng, Yehyun Choi, Euisik Yoon, Celina G. Kleer, "Mesenchymal stem/stromal cell engulfment reveals metastatic advantage in breast cancer," Cell Reports, 27, 3916-3926, 2019.
  • Yu-Heng Cheng*, Yu-Chih Chen*, Eric Lin*, Riley Brien, Yu-Ting Chen, Zhijian Hao, Woncheol Lee, Hyun Min Kang, Jason Cong, Monika Burness, Sunitha Nagrath, Max Wicha, and Euisik Yoon, "Hydro-Seq Enables Contamination-free High-throughput Single-cell RNA-sequencing for Circulating Tumor Cells," Nature Communications, 10, 2163, 2019.
  • Zhixiong Zhang, Lili Chen, Yimin Wang, Tiantian Zhang, Yu-Chih Chen*, and Euisik Yoon*, "Label-free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis," Analytical Chemistry, 91, 21, 14093-14100, 2019.
  • Yu-Chih Chen, Zhixiong Zhang, and Euisik Yoon, "Early Prediction of Single-cell Derived Sphere Formation Using Convolutional Neural Network Image Analysis," Analytical Chemistry, 92, 11, 7717- 7724, 2020.

View Dr. Chen's publications on Google Scholar