Yoram Vodovotz, PhD
Professor of Surgery

Dr. Vodovotz is the Director of the Center for Inflammation and Regenerative Modeling at the McGowan Institute for Regenerative Medicine and a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
W944 Biomedical Sciences Tower
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-3758
Email: vodovotzy@upmc.edu


  • PhD - Cornell University Graduate School of Medical Sciences, 1993

Research Interests

My research interests are centered on systems approaches to the biology of shock states (e.g. septic and hemorrhagic shock), host-pathogen interactions (especially in malaria), wound healing, and chronic inflammatory diseases. As the Director of the Center for Inflammation and Regenerative Modeling (CIRM) at the McGowan Institute for Regenerative Medicine, I have been involved in the mathematical modeling of shock states (e.g. septic or hemorrhagic shock), including cellular and physiological elements, as part of a large, interdisciplinary collaborative team. I am also interested in the cross-regulation of the inducible nitric oxide synthase (iNOS) and the cytokine transforming growth factor-beta-1 (TGF-β1) in various disease states, including malaria infection, cancer, sepsis, and neurodegenerative diseases.

Selected Publications

View Dr. Vodovotz's publications on PubMed

  1. Azhar, N.; Ziraldo, C.; Barclay, D.; Rudnick, D.; Squires, R.; Vodovotz, Y. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS ONE. 2013. 8:e78202.
  2. Ziraldo, C.*; Vodovotz, Y.*; Namas, R.A.; Mi, Q.; Barclay, D.; Almahmoud, K.; Jefferson, B.S.; Chen, G.; Billiar, T.R.; Zamora, R. Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. PLoS ONE. 2013. 8:e79804. *Co-first authors.
  3. Zaaqoq, A.M.; Namas, R.; Almahmoud, K.; Azhar, N.; Mi, Q.; Zamora, R.; Brienza, D.M.; Billiar, T.R.; Vodovotz, Y. Inducible protein-10, a potential driver of neurally-controlled IL-10 and morbidity in human blunt trauma. Crit. Care Med. 2014. 42:1487-1497.
  4. Dutta-Moscato, J.; Solovyev, A.; Mi, Q.; Nishikawa, T.; Soto-Gutierrez, A.; Fox, I.; Vodovotz, Y. A multiscale agent-based model of liver fibrosis progression. Frontiers in Bioengineering and Biotechnology 2014. 2: Article 18.
  5. Nishikawa, T.; Bell, A.; Brooks, J.M.; Setoyama, K.; Melis, M.; Han, B.; Fukumitsu, K.; Handa, K.; Tian, J.; Kaestner, K.H.; Vodovotz, Y.; Locker, J.; Soto-Gutierrez, A.; Fox, I.J. Resetting the transcription factor network reverses terminal chronic hepatic failure. J. Clin. Invest. 2015. 125:1533-44.
  6. Ziraldo, C.; Solovyev, A.; Allegretti, A.; Krishnan, S.; Henzel, M.K.; Sowa, G.A.; Brienza, D.; An, G.; Mi, Q.; Vodovotz, Y. A Computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury. PLoS Comp. Biol. 2015. 11:e1004309.
  7. Brown, D.; Namas, R.A.; Almahmoud, K.; Zaaqoq, A.; Sarkar, J.; Barclay, D.A.; Yin, J.; Ghuma, A.; Abboud, A.; Constantine, G.; Nieman, G.; Zamora, R.; Chang, S.C.; Billiar, T.R.; Vodovotz, Y. Trauma in silico: Individual-specific mathematical models and virtual clinical populations. Sci. Translational Med. 2015. 7:285ra61