Yoram Vodovotz, PhD
Professor of Surgery



Dr. Vodovotz is the Director of the Center for Inflammation and Regeneration Modeling at the McGowan Institute for Regenerative Medicine and a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
W944 Biomedical Sciences Tower
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-3758
Email: vodovotzy@upmc.edu

Education

  • PhD - Cornell University Graduate School of Medical Sciences, 1993

Research Interests

My long-term research goals are to obtain high-dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and people; to create computational models based on these data; and to modulate the inflammatory response in an optimal spatial, temporal, and individual- / disease-specific manner. More specifically, my research interests, carried out in the context of an interdisciplinary research team, are the following:
  1. Systems biology and computational modeling of inflammation, immunity, and wound healing in various disease states, especially infection, trauma/hemorrhage, wound healing, and liver failure, as well as the application of these computational approaches to regenerative medicine, biomarker discovery, and rational drug/device design
  2. Rational Inflammation Reprogramming based on engineering principles and computational modeling

Selected Publications

View Dr. Vodovotz's publications on PubMed

  1. Abboud, A.N.; Namas, R.A.; Ramadan, M.; Mi, Q.; Almahmoud, K.; Abdul-Malak, O.; Azhar, N.; Zaaqoq, A.; Namas, R.; Barclay, D.A.; Yin, J.; Sperry, J.; Peitzman, A.; Zamora, R.; Simmons, R.A.; Billiar, T.R.; Vodovotz, Y. Computational analysis supports an early, type 17 cell-associated divergence of blunt trauma survival and mortality. Crit. Care Med. 2016. 44:e1074-e1081.
  2. Schimunek, L.; Namas, R.; Yin, J.; Liu, D.; Barclay, D.; El-Dehaibi, F.; Abboud, A.; Lindberg, H.; Zamora, R.; Billiar, T.R.; Vodovotz, Y. An enrichment strategy yields seven novel single nucleotide polymorphisms associated with mortality and altered Th17 responses following blunt trauma. Shock. 2018. 49:259-268.
  3. Zamora, R.; Korff, S.; Mi, Q.; Barclay, D.; Yin, J.; Schimunek, L.; Zucca, R.; Arsiwalla, X.D.; Simmons, R.L.; Verschure, P.; Billiar, T.R.; Vodovotz, Y. A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice. PLoS Comp. Biol. 2018. 6: e100658.
  4. Zamora, R.; Barclay, D.; Yin, J.; Alonso, E.M.; Leonis, M.A.; Mi, Q.; Billiar, T.R.; Simmons, R.L.; Squires, R.H.; Vodovotz, Y. HMGB1 is a central driver of dynamic pro-inflammatory networks in Pediatric Acute Liver Failure induced by acetaminophen. Sci. Rep. 2019. 12:9571.
  5. Schimunek, L.; Namas, R.A.; Yin, J.; Liu, D.; Barclay, D.; El-Dehaibi, F.; Abboud, A.; Cohen, M.; Zamora, R.; Billiar, T.R.; Vodovotz, Y. MPPED2 polymorphism is associated with altered systemic inflammation and adverse trauma outcomes. Frontiers in Genetics. 2019. 10:1115. doi: 10.3389/fgene.2019.01115