Donna Beer Stolz, PhD
Associate Professor of Cell Biology

Dr. Stolz is the Director of the Cell Biology and Molecular Physiology Graduate Program Graduate Program Director of Cell Biology and Molecular Biology, and a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
BST South 221
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-383-7283
Lab Telephone: 412-648-8865


  • BS - 1986, University of Massachusetts, Amherst
  • PhD - 1991, University of Massachusetts, Amherst

Research Interests

As Associate Director of the Center for Biologic Imaging, and Director of the Electron Microscopy Arm of the CBI, my main role is to provide collaborative and educational support as well as interpretive analyses for investigators and students in the wide variety of imaging modalities available at the Center. My research interests involve angiogenesis and vascular function, liver endothelial cell biology, liver regeneration and function, and effects of aging on liver and kidney parenchyma and endothelia.

Awards and Honors

  • Graduated summa cum laude, U Mass
  • American Liver Foundation Scholar Award - 1997
  • 2nd and 19th place Nikon Small World Photomicroscopy Contest - 2011

Selected Publications

View Dr. Stolz's publications on PubMed

  1. Xiong, Z, J Cavaretta, L Qu, DB Stolz, D Triulzi, JS Lee. Red blood cell microparticles show altered inflammatory chemokine binding and release upon interaction with platelets. Transfusion. 51(3): 610-621. 2011. PMID: 20738825
  2. Leloup, L. H Shao, YH Bae, B Deasy, D Stolz, P Roy, A Wells. M-calpain activation is regulated by its membrane localization and by its binding to PIP2. J Biol Chem 285(43):33549-33566. 2011 PMID 20729206.
  3. Nakao, A, CS Huang, DB Stolz, Y Wang, JM Franks, N Tochigi, TR Billiar, Y Toyoda, E Tseng, KR McCurry. Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. Cardovasc Res. 89(2):457-63. 2011. PMID 20851811.
  4. Hoppo, T, J Komori, R Manohar, DB Stolz, E Lagasse. Rescue of lethal hepatic failure by Lymph nodes in mice. Gastroenterology. 140(2):656-666. 2011. PMID:21070777
  5. Liang, PH, F Tian, Y Lu, B Duan, DB Stolz, LY Li. Vascular endothelial growth inhibitor(VEGI: TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis lung carcinoma tumors. Angiogenesis 14(1):61-8. 2011. PMID: 21188501.
  6. Lee, KW, DB Stolz, Y Wang. Substantial expression of mature elastin in arterial constructs. PNAS 108(7):2705-2010. 2011. PMID: 21282618.
  7. Soto-Gutierrez, A, L Zhang, C Medberry, K Fukumitzu, D Faulk, H Jiang, J Reing, R Gramignoli, J Komori, M Ross, M Nagaya, E Lagasse, D Stolz, SC Strom, IJ Fox, SF Badylak. A whole-organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods. 17(6):677-686. 2011. PMID 21375407
  8. Wilson, ME, N Kota, Y Kim, Y Wang, DB Stolz, PR LeDuc, OB Ozdoganlar. Fabrication and circular microfluidic channels by combining mechanical micromilling and soft lithography. Lab Chip 11(8):1550-1555. 2011. PMID 221399830.
  9. Li H, P Wang, Q Sun, WX Ding, XM Yin, RW Sobol, DB Stolz, J Yu, J Zhang. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res. 71(10):3625-3634. 2011. PMID 21444671
  10. Bai Q, M Sun, DB Stolz, EA Burton. Major isoform of zebrafish P0 is a 23.5 kDa myelin glycoprotein expressed in selected white matter tracts of the central nervous system. J Comp. Neurol. 519(8):1580-1596. 2011. PMID 21452240.
  11. Park BH, SB Lee, DB Stolz, YJ Lee, BC Lee. Synergistic interactions between heregulin and PPAR gamma agonist in breast cancer cells. J Biol Chem. 286(22):20087-20099. 2011. PMID 21467033.
  12. Ueki S, A Castellaneta, O Yoshida, K Ozaki, M Zhang, S Kimura, K Isse, M Ross, L Shao, DB Stolz, AW Thomson, AJ Demetris, DA Geller, N Murase. Hepatic B7-H1 expression is essential to control cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology. 54(1):216-228. 2011. PMID 21503939.
  13. Goss JR, DB Stolz, AR Robinson, M Zhang, N Arbujas, PD Robbins, JC Glorioso, LJ Niedernhofer. Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev, 132(8-9):437-442. 2011 PMID 21596054
  14. Fischer RT, HR Turnquist, Z Wang, D Beer-Stolz, AW Thomson. Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen-specific CD8(+) T cells in vitro and in vivo. Transpl Immunol 25(1):20-26. 2011. PMID 21596137.
  15. Horzempa J, DM O'Dee, DB Stolz, JM Franks, D Clay, GJ Nau. Invasion of erythrocytes by Fracisella tularensis. J Infect Dis 204(1):51-59. 2011. PMID 21628658
  16. Ghonem, N, J Yoshida, DB Stolz, A Humar, TE Starzl N Murase, R Venkataramanan. Treprostinil, a prostacyclin analogue, ameliorates ischemia-reperfusion injury of rat orthotopic liver transplantation. Am J Transplantation. 11(11):2508-12. 2011. PMID 21668631
  17. Wickline, ED, PK Awuah, J Behari, M Ross, DB Stolz, SP Monga. Hepatocyte gamma-catenin compensates for conditionally deleted beta-catinin at adherens junctions. J Hepatology 55(6):1256-1262. 2011 PMID 21703193
  18. Manohar R, J Komori, L Guzik, DB Stolz, UR Chandran, WA Laframboise, E Lagasse. Identification and expansion of a unique stem cell population from adult mouse gallbladder. Hepatology 54(5):1830-1841. 2011. PMID 21703193
  19. Shields, KJ, D Stolz, SC Watkins, JM Ahearn. Complement proteins C3 and C4 bind to collagen and elastin in the vascular wall: a potential role in vascular stiffness and atherosclerosis. Clin Transl Sci 4(3):146-152. 2011 PMID 21707943.
  20. Thomson, AW, DA Geller, C Gandhi, N Murase, AJ Demetris, D Beer-Stolz. Hepatic antigen-presenting cells and regulation of liver transplant outcome. Immunol Res 50(2-3):221-227. 2011 PMID 21717072
  21. Eum HA, R Vallabhaneni, Y Wang, PA Loughran, D Beer Stolz, TR Billiar. Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-a-treated hepatocytes. Am J Pathol 179(3):1221-1229. 2011. PMID 21741934
  22. Feng H, HJ Kwun, X Liu, O Gjoerup, DB Stolz, Y Chang, PS Moore. Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One 6(7): e22468. 2011 PMID 21799863.
  23. Feng R, S Li, C Lu, C Andreas, D Beer-Stolz, MY Mapara, S Lentzsch. Targeting the microtubular network as a new anti-myeloma strategy. Mol Cancer Ther 10(10): 1886-1896. 2011 PMID 21825007
  24. Lee, LY, T Kaizu, H Toyokawa, M Zhang, M Ross, DB Stolz, C Huang, C Gandhi, DA Geller, N Murase. Carbon monoxide induces hypothermia tolerance in kupffer cells and attenuates liver ischemia/reperfusion injury in rats. Liver Transpl. 17(12):1457-1466. 2011 PMID 21850691.
  25. Ji, J, YY Tyurina, M Tang, W Feng, DB Stolz, R Clark, D Meaney, PM Kochanek, VE Kagan, H Bayir. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: Biomarkers of apoptosis and selective peroxidation on anionic phospholipids. J Neurotrauma. 29(5):776-788. 2011. PMID 21895519.
  26. Turnquist HR, Z Zhao, BR Roseborough, Q Liu, A Castellanata, K Isse, Z Wang, M Lang, D Beer Stolz, XX Zheng, AJ Demetris, FY Liew, KJ Wood, AW Thomson. IL-33 expands suppressive DC11b+Gr-int and regulatory T cells including ST2L+Foxp3+ cells and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol 187(9):4598-4610. 2011, PMID 21949025.
  27. Gregg SQ, V Gutiérrez, AR Robinson, T Woodell, A Nakao, MA Ross, GK Michalopoulos, L Rigatti, CE Rothermel, I Kamileri, George Garinis, D Beer Stolz, LJ Niedernhofer. A mouse model of accelerated liver aging due to a defect in DNA repair. Hepatology, 55(2):609-621. 2012. PMID 21953681
  28. Jaffe M, C Sesti, IM Washington, L Du, N Dronadula, MT Chin, DB Stolz, EC Davis, DA Dichek. Transforming growth factor-beta signaling in myogenic cells regulated vascular morphogenesis, differentiation and matrix synthesis. Arterioscler Thromb Vasc Biol. 32(1);e1-e11. 2012. PMID 21979435
  29. Montecalvo A, AT Larregina, WJ Shufesky, D Beer Stolz, Sullivan, JM Karlsson, CJ Baty, GA Gibson, G Erdos, Z Wang J Milosevic,OA Tkacheva, SJ Divito, R Jordan, J Lyons-Weller, SC Watkins, AE Morelli. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 119(3):756-766. 2012 PMID 22031862.
  30. Li P, Q Du, Z Cao, Z Guo, J Evankovich, W Yan, Y Chang, L Shao, DB Stolz, A Tsung, DA Geller. Interferon-gamma induces autophagy with growth inhibition and cell death in human heptocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett.314(2):213-222. 2011. PMID 22056812.
  31. Hang TC, Lauffenburger, LG Griffith and DB Stolz. Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. Am J Physiol Gastrointestinal Liver Physiol 302(3):G375-388. 2012 PMID 22075778.
  32. Liu L, GR Yannam, T Nishikawa, T Yamamoto, H Basma, R Ito, M Nagaya, J Dutta-Muscato, DB Stolz, F Duan, KH Kaestner, Y Vodovotz, A Soto-Gutierrez, IJ Fox. The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology 55(5):1529-29. 2012. PMID 22109844.
  33. Zhao, Y, NS Mangalmurti, Z Xiong, B Prakash, F Guo, DB Stolz, JS Lee. Duffy antigen receptor mediates chemokine endocytosis though a macropinocytosis-like process in endothelial cells. PLoS One 6(12):e29624. 2011 PMID: 22216333.
  34. Ozaki KS, S Kimura, MA Nalesnik, RM Sico. M Zhang, S Ueki, MA Ross, DB Stolz, N Murase. Loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation. Kidney Int. 2012. PMID 22278023
  35. Sun, Q, T Kawamura, K Masutani, X Peng, Q Sun, DB Stolz, JP Pribis, TR Billiar, X Sun, CA Bermudez, Y Toyoda, A Nakao. Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res. 94(1):144-153. 2012 PMID 22287575
  36. Ikenouchi, J, M Suzuki, K Umeda, K Ikeda, R Taguchi, T Kobayashi, DB Stolz, M Umeda. Lipid polarity is maintained in the absence of tight junctions, J Biol Chem. 287(12):9525-9533. 2012. PMID 22294698.
  37. Rapireddy S, L Nhon, RE Meehan, J Franks, DB Stolz, D Tran, ME Selsted, DH Ly. RTD-1 mimic containing yPNA scaffold exhibits broad spectrum antibacterial activities. J Am Chem Soc. 134(9):4041-4044. 2012 PMID: 22332599.
  38. Dangi, A. TL Sumpter, S Kimura, DB Stolz, N Murase, G Raimondi, Y Vodovotz, C Huang, AW Thomson, CR Gandhi. Selective expansion of allogeneic tegulatory T-cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J. Immunology 188(8):3667-77. 2012. PMID 22427640.
  39. Cihil KM, P Ellinger, A Fellows, D Beer Stolz, DR Madden, Swiatecka-Urban, A. DAB2 facilitates AP-2 independent recruitment of CFTR to endocytic vesicles in polarized human airway epithelial cells. J Biol Chem 287(18):15087-99. 2012. PMID 22399289.
  40. Liang X, ME de Vera, WJ Buscher, A Romo de Vivar Chavez, P Loughran, D Beer-Stolz, P Basse, T Wang, B van Houten, HJ Zeh, M Lotze. Inhibiting autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. Cancer Res 72(11):2791-801. 2012. PMID 22472122
  41. Graves, JA Y Wang, S Sims-Lucas, E Cherok, K Rothermund, MF Branca, J Elster, D Beer-Stolz, B Van Houten, J Vockley, EV Prochownik. Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PLoS One 7(5):e37699. 2012 PMID: 22629444.
  42. Tilstra, JS, AR Robinson, J Wang, SQ Gregg, CL Clauson, DP Reay, LA Nasto, CM St. Croix, A Usas N Vo, J Huard, PR Clemens, DB Stolz, DC Guttridge, SC Watkins, GA Garinis, Y Wang, LJ Niedernhofer, PD Robbins. NF-kB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 122(7):2601-12. 2012. PMID 22706308
  43. Stefanovic-Racic M, Yang X, Turner MS, Mantell BS, Stolz DB, Sumpter TL, Sipula IJ, Dedousis N, Scott DK, Morel PA, Thomson AW, O'Doherty RM. Dendritic cells promote macrophage infiltration and comprise a substantial portion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes 61(9):2330-2339. 2012 PMID: 22851575