Somak Roy, MD
Assistant Professor of Pathology

Dr. Roy is the Associate Director of the Division of Molecular & Genomic Pathology and Director of Molecular Informatics.

Office Information:
Clinical Lab Building
3477 Euler Way
Room 7028
Pittsburgh, PA 15213
Contact Information:
Telephone: 412-864-6190
Email: roys@upmc.edu

Research Interests

Dr. Roy's research is focused on understanding mechanisms of urothelial carcinogenesis and metastasis using next generation sequencing and microarray technologies and development of biomedical informatics solutions for optimizing clinical laboratory operations and quality management.

Selected Publications

View Dr. Roy's publications on PubMed

  • Interactive Browser-Based Genomics Data Visualization Tools for Translational and Clinical Laboratory Applications. Pearce TM, Nikiforova MN, Roy S. J Mol Diagn. 2019 Nov;21(6):985-993. doi: 10.1016/j.jmoldx.2019.06.005. Epub 2019 Aug 2. PMID: 31382034
  • Clinical Utility of GlioSeq Next-Generation Sequencing Test in Pediatric and Young Adult Patients With Brain Tumors. Roy S, Agnihotri S, El Hallani S, Ernst WL, Wald AI, Santana Dos Santos L, Hamilton RL, Horbinski CM, Wadhwani NR, Born DE, Pollack IF, Nikiforov YE, Nikiforova MN. J Neuropathol Exp Neurol. 2019 Jun 10. doi: 10.1093/jnen/nlz055. [Epub ahead of print] PMID: 31298284
  • Cervical cancer subtypes harbouring integrated and/or episomal HPV16 portray distinct molecular phenotypes based on transcriptome profiling of mRNAs and miRNAs. Mandal P, Saha SS, Sen S, Bhattacharya A, Bhattacharya NP, Bucha S, Sinha M, Chowdhury RR, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Chattapadhyay A, Sengupta S. Cell Death Discov. 2019 Mar 25;5:81. doi: 10.1038/s41420-019-0154-x. eCollection 2019. PMID: 30937183
  • Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as Biomarkers. Singhi AD, George B, Greenbowe JR, Chung J, Suh J, Maitra A, Klempner SJ, Hendifar A, Milind JM, Golan T, Brand RE, Zureikat AH, Roy S, Schrock AB, Miller VA, Ross JS, Ali SM, Bahary N. Gastroenterology. 2019 Jun;156(8):2242-2253.e4. doi: 10.1053/j.gastro.2019.02.037. Epub 2019 Mar 2. PMID: 30836094
  • GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE. Thyroid. 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PMID: 30648929
  • Clinical Implementation and Validation of Automated Human Genome Variation Society (HGVS) Nomenclature System for Next-Generation Sequencing-Based Assays for Cancer. Callenberg KM, Santana-Santos L, Chen L, Ernst WL, De Moura MB, Nikiforov YE, Nikiforova MN, Roy S. J Mol Diagn. 2018 Sep;20(5):628-634. doi: 10.1016/j.jmoldx.2018.05.006. Epub 2018 Jun 21. PMID: 29936258
  • KRAS mutation is predictive of outcome in patients with pulmonary sarcomatoid carcinoma. Mehrad M, Roy S, LaFramboise WA, Petrosko P, Miller C, Incharoen P, Dacic S. Histopathology. 2018 Aug;73(2):207-214. doi: 10.1111/his.13505. Epub 2018 May 7. PMID: 29489023
  • Loss of Chromatin-Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times. Roy S, LaFramboise WA, Liu TC, Cao D, Luvison A, Miller C, Lyons MA, O'Sullivan RJ, Zureikat AH, Hogg ME, Tsung A, Lee KK, Bahary N, Brand RE, Chennat JS, Fasanella KE, McGrath K, Nikiforova MN, Papachristou GI, Slivka A, Zeh HJ, Singhi AD. Gastroenterology. 2018 Jun;154(8):2060-2063.e8. doi: 10.1053/j.gastro.2018.02.026. Epub 2018 Mar 2. PMID: 29486199
  • Next-Generation Sequencing Approach to Non-Small Cell Lung Carcinoma Yields More Actionable Alterations. Mehrad M, Roy S, Bittar HT, Dacic S. Arch Pathol Lab Med. 2018 Mar;142(3):353-357. doi: 10.5858/arpa.2017-0046-OA. Epub 2017 Dec 8. PMID: 29219616
  • Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines: A Joint Recommendation of the Association for Molecular Pathology and the College of American Pathologists.
  • Roy S, Coldren C, Karunamurthy A, Kip NS, Klee EW, Lincoln SE, Leon A, Pullambhatla M, Temple-Smolkin RL, Voelkerding KV, Wang C, Carter AB. J Mol Diagn. 2018 Jan;20(1):4-27. doi: 10.1016/j.jmoldx.2017.11.003. Epub 2017 Nov 21. Review. PMID: 29154853
  • Next-generation sequencing-based molecular characterization of primary urinary bladder adenocarcinoma. Roy S, Pradhan D, Ernst WL, Mercurio S, Najjar Y, Parikh R, Parwani AV, Pai RK, Dhir R, Nikiforova MN. Mod Pathol. 2017 Aug;30(8):1133-1143. doi: 10.1038/modpathol.2017.33. Epub 2017 May 26. PMID: 28548125
  • Principles and Recommendations for Standardizing the Use of the Next-Generation Sequencing Variant File in Clinical Settings. Lubin IM, Aziz N, Babb LJ, Ballinger D, Bisht H, Church DM, Cordes S, Eilbeck K, Hyland F, Kalman L, Landrum M, Lockhart ER, Maglott D, Marth G, Pfeifer JD, Rehm HL, Roy S, Tezak Z, Truty R, Ullman-Cullere M, Voelkerding KV, Worthey EA, Zaranek AW, Zook JM. J Mol Diagn. 2017 May;19(3):417-426. doi: 10.1016/j.jmoldx.2016.12.001. Epub 2017 Mar 18. PMID: 28315672
  • Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.
  • Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, Tsimberidou AM, Vnencak-Jones CL, Wolff DJ, Younes A, Nikiforova MN. J Mol Diagn. 2017 Jan;19(1):4-23. doi: 10.1016/j.jmoldx.2016.10.002. Review. PMID: 27993330
  • Big data from small samples: Informatics of next-generation sequencing in cytopathology. Roy-Chowdhuri S, Roy S, Monaco SE, Routbort MJ, Pantanowitz L. Cancer Cytopathol. 2017 Apr;125(4):236-244. doi: 10.1002/cncy.21805. Epub 2016 Dec 5. Review. PMID: 27918649