Melanie Koenigshoff, MD, PhD
Professor of Medicine

Dr. Koenigshoff is a Professor of Medicine (under committee review), Associate Chief of Research, Division of Pulmonary, Allergy, and Critical Care Medicine

Office Location:
Division of Pulmonary, Allergy, and Critical Care Medicine
Department of Medicine
200 Lothrop Street
BST W1244
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-7784

Research Interests

The Königshoff Lab focuses on deciphering mechanisms involved in lung injury, aging and regeneration, with the aim to identify novel therapeutic targets relevant for chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis. The translational research program focuses on the comprehensive characterization of biospecimen from human tissue and patient cohorts, including broad phenotyping of lung cells using state of the art molecular and computational biology tools. Current studies investigate the role of developmental pathways and stem cells in chronic lung diseases. The laboratory further pioneered the development and applications of clinically relevant patient-derived 3D human tissue based models, such as precision cut lung slices and organoids hat allow to further validate and test potential novel drugs in an individualized fashion.

Selected Publications

  1. Conlon TM, John-Schuster G, Heide D, Pfister D, Lehmann M, Hu Y, Ertüz Z, Lopez MA, Ansari M, Strunz M, Mayr C, Ciminieri C, Costa R, Kohlhepp MS, Guillot A, Günes G, Jeridi A, Funk MC, Beroshvili G, Prokosch S, Hetzer J, Verleden SE, Alsafadi H, Lindner M, Burgstaller G, Becker L, Irmler M, Dudek M, Janzen J, Goffin E, Gosens R, Knolle P, Pirotte B, Stoeger T, Beckers J, Wagner D, Singh I, Theis FJ, de Angelis MH, O'Connor T, Tacke F, Boutros M, Dejardin E, Eickelberg O, Schiller HB, Königshoff M, Heikenwalder M, Yildirim AÖ. Inhibition of LT?R signalling activates WNT-induced regeneration in lung. Nature. 2020 Nov 4. doi: 10.1038/s41586-020-2882-8.
  2. Hu Y, Ng-Blichfeldt JP, Ota C, Ciminieri C, Ren W, Hiemstra PS, Stolk J, Gosens R, Königshoff M. Wnt/b-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. Stem Cells. 2020 Nov;38(11):1467-1478. doi: 10.1002/stem.3241.
  3. Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M*, Wagner DE*. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L896-L902. doi: 10.1152/ajplung.00084.2017.
  4. Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/?-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Jul 15;196(2):172-185. doi: 10.1164/rccm.201605-0904OC.
  5. Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017 Jan;214(1):143-163. doi: 10.1084/jem.20160675.