Corrine Kliment, MD, PhD
Assistant Professor

Dr. Kliment is a faculty member of Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
Starzl Biomedical Science Tower, W1254
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-4298

Research Interests

COPD, Epithelial biology, airway and ciliary function, mitochondrial biology

Our laboratory is interested in identifying new molecular pathways in the pathogenesis of tissue remodeling in chronic obstructive lung disease (COPD) and other airway diseases to improve therapeutic options for patients. Our lab specifically studies the role of adenine nucleotide translocase (a canonical mitochondrial ADP/ATP transporter) in the airway and alveolar epithelium of the lung in the context of cigarette smoking-related lung disease and airway disease such as cystic fibrosis. We want to better understand how in health and disease ANT regulates epithelial cell metabolism, airway hydration and homeostasis through the action of tiny motile cilia in the airway. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine metabolic regulation and airway homeostasis in the lung.

Selected Publications

  1. Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estepar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H, Hunninghake GM. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulmonary Medicine. 2015; 15: 134.
  2. Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. Journal of Leukocyte Biology. 2015; 98(2): 143-52.
  3. Kliment CR, Englert JM, Cru LP, Oury TD. A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. International Journal of Clinical and Experimental Pathology. 2011; 4(4): 349-5.
  4. Kliment CR, Oury TD. Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding. Free Radical Biology & Medicine. 2011; 50(9): 1075-80.
  5. Kliment CR, Oury TD. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radical Biology & Medicine. 2010; 49(5): 707-17.
  6. Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Medicine. 2010; 16(2): 219-23.
  7. Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. JBC. 2009; 284(6): 3537-45.
  8. Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. Journal of Molecular and Cellular Cardiology. 2009; 47(5): 730-42.
  9. Myllarniemi M, Lindholm P, Ryynanen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 2008; 177(3): 321-9.
  10. Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxidants & Redox Signaling. 2008; 10(2): 261-8.