Dong, Zhou MD, PhD
Assistant Professor of Pathology

Dr. Zhou
Dr. Zhou is a member of the Division of Experimental Pathology.

Office Location:
University of Pittsburgh
Department of Pathology
200 Lothrop St, Room S-429
Pittsburgh, PA 15261

Contact Information:
Office Telephone: 412-648-9508
Fax: 412-648-1916
Email: zhoudong@pitt.edu

Awards and Honors

  • Pathology Postdoctoral Research Training Program (PPRTP) Award, 2014-2015

Research Interests

Currently, Dr. Zhou's main line of research focuses on understanding the pathogenesis of acute kidney injury (AKI). He has demonstrated that specific depletion of Wnt/?-catenin or hepatocyte growth factor (HGF) signaling in renal tubular epithelial cells significantly aggravated renal damages in various insults caused AKI. Recently, he further demonstrated that fibroblast-specific ?-catenin signaling can control renal tubules injury and repair after AKI by modulating HGF expression. These results uncover a previously unrecognized role for interstitial fibroblasts in the pathogenesis of AKI, which enhance our understanding of the specific roles of Wnt signaling in particular cell types after kidney injury. This series of work has provided advance insights into elucidating the renal protective mechanisms of Wnt and HGF in AKI setting. Meanwhile, these AKI work will also be instrumental in constructing AKI early warning system and is expected to be translated into clinic.

Selected Publications

  • Zhou D, Fu H, Xiao L, Mo H, Zhuo H, Tian X, Lin L, Xing J, Liu Y. Fibroblast-specific ?-catenin signaling dictates the outcomes of acute kidney injury. J. Am. Soc. Nephrol. 2018. 29: 1257-1271
  • Zhou D, Fu H, Zhang L, Zhang K, Min Y, Xiao L, Lin L, Bastacky. S, Liu Y. Tubule-derived Wnts are required for fibroblast activation and kidney fibrosis. J. Am. Soc. Nephrol. 2017, 28: 2322-2336
  • Zhou D, Tian Y, Sun L, Xiao L, Tan RJ, Tian J, Fu H, Hou FF, Liu Y. Matrix Metalloproteinase-7 is a urinary biomarker and pathogenic mediator of kidney fibrosis. J. Am. Soc. Nephrol. 2017, 28: 598-611
  • Zhou D, Liu Y. Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis. Nature Review Nephrology. 2016,12:68-70
  • Zhou D, Li Y, Zhou L, Tan RJ, Xiao L, Hou FF and Liu Y. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J. Am. Soc. Nephrol. 2014, 25: 2187-2200
  • Zhou D, Tan RJ, Lin L, Zhou L and Liu Y. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 2013. 84, 509-520
  • Zhou D, Li Y, Lin L, Zhou L, Igarashi P, and Liu Y. Tubule-specific ablation of endogenous ?-catenin aggravates acute kidney injury in mice. Kidney Int. 2012,82:537-547