Hematopathology Center of Excellence

Faculty


CD123 immunohistochemical stain, Castleman Disease

Mission Statement

The Division of Hematopathology, based at UPMC Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division staff includes nine faculty members with varied areas of expertise, three fellows, and an administrative staff.

Service

The Division based at the Hill Building and the Clinical Laboratory Building serves as the Diagnostic Hematopathology resource for the UPMC Health System, as well as for others in our region and beyond. It is directly responsible for all the diagnostic hematopathology at UPMC Presbyterian, UPMC Shadyside, The UPMC Hillman Cancer Center, and The UPMC Childrens Hospital of Pittsburgh. In addition to diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division supervises a large Flow Cytometry Laboratory, the general hematology laboratories that serve UPMC Presbyterian, UPMC Shadyside, and UPMC Magee-Womens Hospital. The division has active Consultation Services, accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data and molecular cytogenetic data.

Education

The Division is active in medical student education including a senior elective in hematopathology, providing longitudinal experiences for MD/PhD students and some graduate student education. The Division also has an ACGME accredited fellowship program (Hematopathology Fellowship). Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Rotations are also provided for clinical hematology/oncology fellows and other fellows in our department. Divisional members are also involved in a variety of national/international teaching activities.

Research

The Division emphasizes several major areas of investigation. Current ongoing basic research focuses on the pathogenesis in iron-deficiancy anemia. A large area of ongoing investigation is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations as well as myeloid neoplasms. Specific areas of interest have included small B-cell lymphomas, aggressive B-cell lymphomas, T-cell lymphomas, post-transplant lymphoproliferative disorders and selected myeloid neoplasms. Techniques range from standard morphology to complete genotypic next generation sequencing studies. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology such as myeloid neoplasms or the lymphoid microenvironment is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.