Microscopic Description -- Abdominal Bloating and Discomfort


Sections of the uterus from the autopsy specimen (Fig. 6) as well as from the biopsy (Fig. 7) taken at laparotomy show an infiltrate of relatively large, monomorphic cells with irregular nuclear contours, vesicular chromatin and variably prominent nucleoli. The cytoplasm is scant and wispy and generally amphophilic. Some cells in the peritoneal biopsy (Fig. 8) show more eosinophilic cytoplasm and scant neutrophils are seen. Areas within the biopsy show brisk mitotic activity and confluent necrosis.

Section of the gastrointestinal tract (Fig. 9) shows hemorrhagic autolyzed mucosa with extensive transmural infiltrate of cells previously described above.

Immunohistochemical stains for leucocyte common antigen/CD45 (Fig. 10), CD34 (Fig. 11), and CD43 (Fig. 12) show the infiltrate is diffusely positive. Stain for lysozyme (Fig. 13) shows a moderate number of positive cells while CD68/PGM-1 (Fig. 14) shows an occasional positive cell. Stains for CD3 (Fig. 15), L26 (Fig. 16), and CD79a (Fig. 17) are negative.


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