The Department of Pathology Residency Program -

The Division of Hematopathology offers the resident exposure to all facets of daily hematopathology laboratory operations, from understanding laboratory instrumentation to quality control procedures. In addition, the resident develops an understanding of diseases of the peripheral blood, bone marrow, and lymph nodes through exposure to a large volume of clinical case material. The resident ultimately develops integrative and discriminatory skills to propose a differential diagnosis and to consider the necessary steps to achieve a final diagnosis.

Residents begin with a review of Kodachrome and glass slide study sets available for the morphologic study of peripheral blood, bone marrow aspirate, and biopsy and become familiar with appropriate terminology and principles of hematopoiesis. They progress to evaluation of assigned cases by performing differential counts of the peripheral blood and bone marrow aspirate, interpreting bone marrow biopsies, and obtaining pertinent clinical histories from patient charts. All cases are then reviewed and signed out.

The Bone Marrow Transplantation Division of Montefiore University Hospital offers residents numerous opportunities to learn the pathology associated with bone marrow transplantation as well as effects of cytokines and other newer treatment modalities. Residents also participate in the sign-out of lymph node biopsies and become familiar with immunohistochemical stains used in the diagnosis of lymphoproliferative disease. In conjunction with the reading of the marrows, the resident is introduced to principles of flow cytometry and the evaluation of cytochemistries as they pertain to the diagnosis of hematologic disease. During two weeks in the Pediatric Hematology Division of Children's Hospital, residents become proficient in the evaluation and interpretation of pediatric peripheral smears and bone marrow aspirates.

At the end of the rotation, residents will have developed expertise in the evaluation of peripheral blood, bone marrow, and lymph node pathology and understand the principles of hematology laboratory medicine.

Research Emphasis

The studies in this division include the study of cell phenotypes in malignant lymphomas, the use of cytochemistries and immunohistochemical staining to study leukemias and other lymphoid cell neoplasias, the biochemistry of leukocyte-platelet interactions, the metabolism of leukocytes, the enzymatic structure of normal and leukemic leukocytes, and the biochemistry of phagocytosis.
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