Hang Lin, PhD
Assistant Professor

Dr. Lin is a member of the Cellular and Molecular Pathology Graduate Training Program.

Office Location:
Bridgeside Point II
Room 217, 450 Technology Drive
Pittsburgh, PA, 15219
Contact Information:
Office Telephone: 412-624-5503
Email: hal46@pitt.edu

Research Interests

The main research interest in Lin lab is to understand the etiology and pathogenesis of osteoarthritis, and develop the treating methods accordingly.

  1. A human cell derived, three-dimensional (3D), multi-component microphysiological joint chip (microJoint) has been developed, in which osteochondral complexes, synovium and adipose tissues are integrated. This robust in vitro system is being used to study the tissue crosstalk in the onset and progression of osteoarthritis, as well as screen the disease modifying drugs.
  2. Aging relevant changes in cartilage/chondrocyte is investigated, with special attention to autophagy. Our final goal is to understand the mechanism underneath the association between aging and osteoarthritis.
  3. Stem cell and its biologics-based therapy is also tested for the treatment of musculoskeletal injuries such as focal cartilage defect, which is one of the major reasons leading to the development of osteoarthritis.

Selected Publications

View Dr. Lin's publications on PubMed

  1. Deng Y, Lei G, Lin Z, Yang Y, Lin H (corresponding author), Tuan RS. Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/?-catenin pathway. Biomaterials. 2019, 192:569-578.
  2. Deng Y, Sun AX, Overholt KJ, Yu GZ, Fritch MR, Alexander PG, Shen H, Tuan RS, Lin H (corresponding author). Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-?. Acta Biomater. 2019, 83:167-176.
  3. Yang Y, Lin H (co-first author), Shen H, Wang B, Lei GH, Tuan RS. Mesenchymal Stem Cell-Derived Extracellular Matrix Enhances Chondrogenic Phenotype of and Cartilage Formation by Encapsulated Chondrocytes in vitro and in vivo. Acta Biomaterialia, 2018, 69:71-82.
  4. Lin H, Sohn J, Langhans MT, Shen H, Tuan RS. Bone Marrow Mesenchymal Stem Cells: Aging and Tissue Engineering Applications to Enhance Bone Healing. Biomaterials, 2018, S0142-9612(18)30447-2.
  5. Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS. Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1?. Molecular Pharmaceutics, 2014, 11(7):2203-12.
  6. Lin H, Cheng AWM, Alexander P, Bech AM, Tuan RS. Cartilage Tissue Engineering Application of Injectable Gelatin Hydrogel with in situ Visible Light-Activated Gelation Capability in Both Air and Aqueous Solution. Tissue Engineering-A, 2014, 20 (17-18): 2402-11.
  7. Lin H, Zhang DN, Alexander P, Yang G, Tan J, Cheng AWM, Tuan RS. The Application of Visible Light-based Projection Stereolithography (VL-PSL) in Live Cell-Scaffold Fabrication with Designed Architecture. Biomaterials 2013, 34(2):331-9
  8. Lin H, Yang G, Tan J, Tuan RS. Influence of Decellularized Matrix Derived from Human Mesenchymal Stem Cells on Their Proliferation, Migration and Multi-lineage Differentiation Potential. Biomaterials 2012, 33(18):4480-9.