Jianhui Zhu, MD, PhD
Research Assistant Professor of Pathology

Dr. Zhu is a member of the Division of Experimental Pathology.

Office Location:
A518 Scaife Hall
Department of Pathology
200 Lothrop Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-648-8315
Lab Telephone: 412-383-5380
Email: jiz19@pitt.edu


  • M.Med. - 1990, Shanghai Medical University
  • PhD - 2000, The Chinese University of Hong Kong

Research Interests

Research interests include: 1. the role of intracellular signaling pathways, in particular, MEK-ERK pathway on regulation of mitochondrial biogenesis and dynamics in Parkinsonian neurotoxin, MPP+ models; 2.involvement of autophagy-lysosome dysfunction in the pathogenesis of neurotoxic and genetic models of Parkinson's disease.

Selected Publications

View Dr. Zhu's publications on PubMed

  • Zhu JH and Chu C (2010) Mitochondrial dysfunction in Parkinson's disease: J Alzheimer's Dis. 20: S325-S334
  • Hu XM, Weng ZF, Chu CT, Zhang LL, Cao GD, GaoYQ, Signore A, Zhu JH, Hastings T, Greenamy JT and Chen J (2011) Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the ASK1 signaling cascade. J Neurosci. 5;31(1):247-61
  • Zhu JH, Dagda RK and Chu CT (2011) Monitoring mitophagy in neuronal cell cultures. Methods in Mol Biol. 793: 325-39
  • Gusdon AM, Zhu JH, Van Houten B, Chu CT (2012) ATP13A2 regulates mitochondrial bioenergetics through macroautophagy, Neurobiol. Dis, doi:10.1016/j.nbd.2011.12.015.
  • Zhu JH, Gusdon AM, Cimen H, Van Houten B, Koc E, Chu CT (2012) Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2. Cell Death & Disease. doi: 10.1038/cddis.2012.46