Michelle A. Wood-Trageser, PhD
Research Instructor

Dr. Wood-Trageser
Dr. Wood-Trageser is a Research Assistant Professor with the Division of Transplant Pathology. She serves as a co-director for the CAP/CLIA certified Research Histology Services Laboratory.
Office Location:
200 Lothrop Street
BST E1503
Pittsburgh, PA 15213
Contact Information:
Lab Telephone: 412-624-1402
Email: woodma4@upmc.edu

Education

  • BS - Elizabethtown College, 2004
  • PhD - University of Pittsburgh, 2009

Research Interests

As co-director of the Research Histology Services Laboratory, Dr. Wood-Trageser's research interests revolve around using traditional histopathological approaches in conjunction with multiplex immunohistochemistry and digital analysis of images to enhance understanding of disease processes within the tissue. The focus of the laboratory, under direction with Dr. A. Jake Demetris, is understanding the immune microenvironment within biopsy tissues. More recent endeavors by the laboratory will focus on bringing genomic capabilities to the laboratory for development of novel clinical tests that will correlate geographical information from biopsies with molecular signatures.

Dr. Wood-Trageser's research expertise is in:

  • Molecular Biology
  • Genomics
  • Cell Biology
  • Mouse Models

Awards and Honors

  • Dorothy Lyet Research Endowment, Summer Research Stipend, Elizabethtown College, 2002, 2003
  • Beta Beta Beta, Biological Honors Society, Elizabethtown College, 2003 - 2004
  • Distinguished Student Award, Elizabethtown College, 2003, 2004
  • Stephen L. Phillips Scientific Achievement Award, University of Pittsburgh, School of Medicine, 2008
  • Gary Betty Scholar, University of Michigan, 2009
  • Trainee Day Travel Award, Endocrine Society, 2009
  • Outstanding Abstract Award, Endocrine Society, 2011
  • Lalor Foundation Travel Fellow, Society for the Study of Reproduction, 2014
  • Cornelia Post Channing New Investigator Award, Society for the Study of Reproduction, 2014
  • Dr. Paul M. Rike Fellowship Award, Magee-Womens Research Institute, University of Pittsburgh, 2014

Selected Publications

View Dr. Wood-Trageser's publications on PubMed

Multiplex IHC and Digital Pathology

  1. Feingold, B., J. Picarsic, A. Lesniak, B.A. Popp, M.A. Wood-Trageser, A.J. Demetris. Late graft dysfunction after pediatric heart transplantation is associated with fibrosis and microvasculopathy by automated, digital whole-slide analysis. J Heart Lung Transplant; 36:1336-43, 2017.
  2. Wood, M.A., A. Acharya, I. Finco, M.J. Elston, M.D. Tallquist, G.D. Hammer. Fetal Adrenal Capsular Cells Serve as a Progenitor Cell Niche for Steroidogenic and Stromal Adrenocortical Cell Lineages in Mice. Development. 140:4522-4532, 2013.

Genomics

  1. Ren, R., F. Diao, S. Katari, S. Yatsenko, H. Jiang, M.A. Wood-Trageser, and A. Rajkovic. Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian failure. Molecular Genetics & Genomic Medicine. 2018 Mar;6(2):276-281
  2. Gurbuz, F., S. Desai, F. Diao, F. Wranitz, M.A. Wood-Trageser, Y.H. Shin, L.D. Kotan, H. Jiang, S. Witchel, N. Gurtunca, S. Yatsenko, D. Mysliwec, K. Topaloglu, A. Rajkovic. Novel Inactivating Mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model. Clinical Genetics, 2018 Apr;93(4):853-859.
  3. Desai, S.*, M. Wood-Trageser*, J. Matic, J. Chipkin, H. Jiang, A. Bachelot, J. Dulon, C. Sala, C. Barbieri, M. Cocca, D. Toniolo, T. Philippe, S. Witchel, A. Rajkovic. MCM8 and MCM9 nucleotide variants in women with primary ovarian insufficiency. Journal of Clinical Endocrinology & Metabolism. 102(2):576-582, 2017. *Authors contributed equally to this work.
  4. Yatsenko, S.A., P. Mittal, M.A. Wood-Trageser, M. McGuire, S. Cercone, M. Jones, L. Hoffner, U. Surti, R. Edwards, A. Sood, H. Jiang, A. Rajkovic. Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays. Fertility and Sterility, 107(2):457-466, 2017
  5. Yatsenko, S.A., H.A. Bakos, K. Vitullo, M. Kedov, A. Kishore, B.J. Jennings, U. Surti,
  6. , S. Cercone, A.N. Yatsenko, A. Rajkovic, and A. Iannaccone. High-resolution microarray analysis unravels complex Xq28 aberrations in patients and carriers affected by X-linked blue cone monochromacy. Clinical Genetics, 89(1): 82-87, 2016.
  7. Katari S., M.A. Wood-Trageser, H. Jiang, E. Kalynchuk, R Muzumdar, S.A. Yatsenko, and A. Rajkovic. Novel Inactivating Mutation of the FSH Receptor in Two Siblings of Indian Origin with Premature Ovarian Failure. Journal of Clinical Endocrinology and Metabolism. 100(6):2154-2157, 2015.
  8. Al Asiri, S.*, S. Basit*, M.A. Wood-Trageser*, S.A. Yatsenko, E.P. Jeffries, U. Surti, D.M. Ketterer, S. Afzal, K. Ramzan, M. Faiyaz-Ul Haque, H. Jiang, M.A. Trakselis, and A. Rajkovic. Exome sequencing identifies MCM8 mutation in ovarian failure and chromosomal instability. Journal of Clinical Investigation. 125(1):258-262, 2015. *Authors contributed equally to this work.
  9. Wood-Trageser, M.A., F. Gurbuz, S.A. Yatsenko, E.P. Jeffries, L. D. Kotan, U. Surti, D.M. Ketterer, J. Matic, J. Chipkin, H. Jiang, M.A. Trakselis, A.K. Topaloglu, and A. Rajkovic. MCM9 mutations are associated with ovarian failure, short stature and chromosomal instability. American Journal of Human Genetics. 95(6):754-62, 2014.