Jansen N. Seheult, MB BCh BAO, MSc, MD, LRCP&SI
Clinical Assistant Professor of Pathology

Dr. Seheult is Assistant Medical Director of the Vitalant Diagnostics Coagulation Laboratory and a staff physician in the Division of Transfusion Medicine.

Office Location:
Institute for Transfusion Medicine
3636 Blvd. of the Allies
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-209-7157
Fax: 412-209-7325
Email: seheultjn@upmc.edu

Education

  • MB BCh BAO (Hons), LRCP&SI - Royal College of Surgeons in Ireland, 2006-2011
  • MSc in Clinical Chemistry - Trinity College Dublin, 2012-2014
  • Doctor of Medicine - Royal College of Surgeons in Ireland, 2013-2015
  • MS candidate in Analytical Chemistry - Illinois Institute of Technology, 2015-Present
  • Internship - Internal Medicine and General Surgery, Health Service Executive, Ireland, 2011-2012
  • Clinical Pathology Residency, University of Pittsburgh Medical Center, 2014-2017
  • Blood Bank/ Transfusion Medicine Fellowship, University of Pittsburgh Medical Center, 2017-2018
  • Special Coagulation Fellowship, Mayo Clinic Rochester, 2018-2019

Clinical Expertise

Dr. Seheult has expertise in the areas of transfusion medicine, laboratory coagulation, disorders of hemostasis and thrombosis, and clinical chemistry.

Research Interests

Dr. Seheult has been heavily involved in clinical and translational research, with a primary focus on the laboratory diagnosis of the antiphospholipid syndrome and a secondary focus on the use of low-titer group O+ cold-stored whole blood in damage control resuscitation to minimize trauma-induced coagulopathy. Dr. Seheult has research expertise in special coagulation, analytical chemistry, in silico modeling, machine learning and statistics.

Selected Publications

View Dr. Seheult's publications on PubMed

  • Seheult JN, Anto VP, Farhat N, Stram MN, Spinella PC, Alarcon L, Sperry J, Triulzi DJ, Yazer MH. Application of a recursive partitioning decision tree algorithm for the prediction of massive transfusion in civilian trauma: the MTPitt prediction tool. Transfusion. 2019 Mar;59(3):953-964. doi: 10.1111/trf.15078. Epub 2018 Dec 12. PMID: 30548461.
  • Seheult JN, Stram MN, Sperry J, Spinella PC, Triulzi DJ, Yazer MH. In silico model of the dilutional effects of conventional component therapy versus whole blood in the management of massively bleeding adult trauma patients. Transfusion. 2019 Jan;59(1):146-158. doi: 10.1111/trf.14983. Epub 2018 Nov 9. PMID: 30414181
  • Rasheed E, Seheult J, Gibney J, Boran G. Does thyrotoxic periodic paralysis have a genetic predisposition? A case report. Ann Clin Biochem. 2018 Nov;55(6):713-716. doi: 10.1177/0004563218785395. Epub 2018 Jul 20. PMID: 29886759.
  • Stram MN, Suciu CN, Seheult JN, McCullough MA, Kader M, Wells A, William Pasculle A, Rinaldo CR, Ismail N. Herpes Simplex Virus-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections in Organ Transplant Recipients and Critically Ill Patients. Am J Clin Pathol. 2018 Oct 24;150(6):522-532. doi: 10.1093/ajcp/aqy088. PMID: 30212869.
  • Seheult JN, Bahr M, Anto V, Alarcon LH, Corcos A, Sperry JL, Triulzi DJ, Yazer MH. Safety profile of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients. Transfusion. 2018 Oct;58(10):2280-2288. doi: 10.1111/trf.14771. Epub 2018 May 25. PMID: 29802644.
  • Seheult JN, Anto V, Alarcon LH, Sperry JL, Triulzi DJ, Yazer MH. Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation. Transfusion. 2018 Aug;58(8):1838-1845. doi: 10.1111/trf.14779. Epub 2018 Aug 30. PMID: 30160310.
  • Sulaiman I, Greene G, MacHale E, Seheult J, Mokoka M, D'Arcy S, Taylor T, Murphy DM, Hunt E, Lane SJ, Diette GB, FitzGerald JM, Boland F, Sartini Bhreathnach A, Cushen B, Reilly RB, Doyle F, Costello RW. A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma. Eur Respir J. 2018 Jan;51(1). doi: 10.1183/13993003.01126-2017. Print 2018 Jan. PMID: 29301919.
  • Sulaiman I, Seheult J, Sadasivuni N, MacHale E, Killane I, Giannoutsos S, Cushen B, Mokoka MC, Bhreathnach AS, Boland F, Reilly RB, Costello RW. The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler. J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):247-255. doi: 10.1089/jamp.2016.1334. Epub 2017 Mar 9. PMID: 28277810.
  • Seheult JN, Meyer MP, Bontempo FA, Chibisov I. The Effects of Indirect- and Direct-Acting Anticoagulants on Lupus Anticoagulant Assays: A Large, Retrospective Study at a Coagulation Reference Laboratory. Am J Clin Pathol. 2017 Jun 1;147(6):632-640. doi: 10.1093/ajcp/aqx035. PMID: 28525532.
  • Seheult JN, Triulzi DJ, Alarcon LH, Sperry JL, Murdock A, Yazer MH. Measurement of haemolysis markers following transfusion of uncrossmatched, low-titre, group O+ whole blood in civilian trauma patients: initial experience at a level 1 trauma centre. Transfus Med. 2017 Feb;27(1):30-35. doi: 10.1111/tme.12372. Epub 2016 Oct 12. PMID: 27730689.