Miguel Reyes-Múgica, MD
Marjory K. Harmer Endowed Chair in Pediatric Pathology

Miguel Reyes-Múgica, MD
Dr. Reyes-Múgica is the Chief of the Division of Pediatric Pathology.
Office Location:
Department of Pathology
Children's Hospital of Pittsburgh
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh PA 15224
Contact Information:
Office Telephone: 412-692-5650
Fax: 412-692-6550
Email: miguel.reyes@chp.edu

Jinmi Kim - Administrative Coordinator
Office Telephone: 412-692-6543
Email: kimj31@upmc.edu


  • MD - National Autonomous University of Mexico (UNAM), México City, México, 1982

Clinical Expertise

Neural Crest Disorders, in particular Congenital Melanocytic Proliferations, Pediatric Testicular Pathology, Pediatric Tumors and Cancer Predisposition Syndrome.

Research Interests

My main interests include the study of biological features of a group of disorders knows as "neurocristopathies". In particular, the biology of congenital nevi, and the improvement of diagnostic approaches to the complex neural crest malformation called Hirschsprung disease.

In our laboratory we concentrate in pediatric melanocytic proliferations, in particular Giant Congenital Melanocytic Nevi and a relatively rare associated entity called neurocutaneous melanocytosis (NCM). Patients with this condition are born with large pigmented nevi and later develop meningeal/brain melanocytic proliferations. Little is known about the biology of these lesions and how they compare with other, more conventional melanocytic proliferations, such as malignant melanoma. Our past efforts have centered on studying genes associated with familial melanoma, which apparently are not involved in this condition. Now we are working in collaboration with a number of clinical and surgical researchers, and with the support group Nevus Outreach, Inc., we have established a tissue repository for samples samples derived from patients afflicted with these conditions. In addition, a recent gift from a generous family was received to support our tissue repository, which has now been renamed as "The Gavin Bailey Tissue Repository for Neural Crest Disorders". At the time of this report, we have accumulated samples from approximately 130 patients afflicted with Giant Melanocytic Nevi, including 21 patients with NCM. In collaboration with Dr. Marina Nikiforova, from the Molecular Pathology Laboratory, we have interrogated our samples in regard to their NRAS, BRAF (and other target genes) status. Our results showing BRAF mutations in NCM patients, as well as a particular phenotype associated with BRAF mutations in Giant Nevi, were presented at the joint SPP/PPS meeting in Birmingham, UK, in September 2014, and published in Januray of 2015. An Editorial comment on these studies appeared in Dermatology Times. This advanced genetic and morphological characterization of NCM lesions, will improve our understanding of their biology, allowing us to discover potential targets for therapy. We have also found that not only mutations, but amplification of mutated NRAS appears to play a significant role in melanomagenesis in the context of NCM. This observation has been accepted for publication in Melanoma Research. We have ongoing collaborations with Ruth Halaban from Yale, and are working with Dr. Harper Price from Phoenix Children's Hospital to accrue more tissues from her patients. Dr. Stewart Cramer, an expert in the field of nevogenesis, and are working with a group of pediatric and adult nevi, establishing comparisons in terms of their immunophenotype and maturation patterns.

An additional field of interest is the pathology of pediatric testicular lesions. We continue working with the groups of Pediatric Endocrinology and Pediatric Urological Surgery in order to analyze patients with Disorders of Sex Development, trying to expand their characterization. This work is also in collaboration with Dr. Katja Gwin, from Southwestern University. In this context, I have recently published 20 out of 25 chapters (peer-reviewed articles) for a supplement dedicated to Pediatric Testicular Pathology, sponsored by the Society for Pediatric Pathology, the bound volume will be published in 2016, but each chapter/article will be finished (as of this writing only 5 remain in review) by the end of 2015.

Lastly, I continue collaborative work with the ELGAN (Extremely Low Gestational Age Neonate) group, and also work on other areas of General Pediatric Pathology, specifically, tumor pathology.


  • Pediatric and Developmental Pathology, Editor-in-Chief
  • Society for Pediatric Pathology
  • United States and Canadian Academy of Pathology
  • International Paediatric Pathology Association, President -Elect
  • Asociación Mexicana de Patólogos
  • Sociedad Latinoamericana de Patologia Pediatrica (SLAPPE)
  • Sociedad Latinoamericana de Patologia (SLAP)
  • College of American Pathologists
  • Latin American Pathology Foundation, Ex-President

Selected Publications

View Dr. Reyes-Múgica's publications on PubMed

Peer-Reviewed Articles

  • Peterson C, Toll SA, Kolb B, Poulik JM, Reyes-Mugica M, Sood S, Haridas A, Wang ZJ, Marupudi NI. Novel Finding of Copy Number Gains in GNAS and Loss of 10q in a Child With Malignant Transformation of Neurocutaneous Melanosis Syndrome JCO Precis Oncol. 2021 Nov;5:33-38. doi: 10.1200/PO.20.00244. PMID: 34994589
  • Pfister SM, Reyes-Múgica M, Chan JKC, Hasle H, Lazar AJ, Rossi S, Ferrari A, Jarzembowski JA, Pritchard-Jones K, Hill DA, Jacques TS, Wesseling P, López Terrada DH, von Deimling A, Kratz CP, Cree IA, Alaggio R. A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era. Cancer Discov. 2021 Dec 17. doi: 10.1158/2159-8290.CD-21-1094. PMID: 34921008 Review.
  • Przybycin CG, Williamson SR, Kao CS, Reyes-Múgica M, Ulbright TM, McKenney JK. Nodular Maturation of the Testis: A Non-neoplastic Lesion of Boys That May Present as a Mass on Clinical and Ultrasound Examination. Am J Surg Pathol. 2022 Feb 1;46(2):220-225. doi: 10.1097/PAS.0000000000001775.PMID: 34881635
  • Ningappa M, Adenuga M, Ngo KA, Mohamed N, Narayanan T, Prasadan K, Ashokkumar C, Das J, Schmitt L, Hartman H, Sehrawat A, Salgado CM, Reyes-Mugica M, Gittes GK, Lo CW, Subramaniam S, Sindhi R. Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants. Front Physiol. 2021 Jul 14;12:658518. doi: 10.3389/fphys.2021.658518. eCollection 2021.PMID: 34366878 Free PMC article.
  • Henkel SAF, Salgado CM, Reyes-Mugica M, Soltys KA, Strauss K, Mazariegos GV, Squires RH, McKiernan PJ, Zhang X, Squires JE. Long-term liver transplant outcomes for progressive familial intrahepatic cholestasis type 1: The Pittsburgh experience. Pediatr Transplant. 2021 Dec;25(8):e14108. doi: 10.1111/petr.14108. Epub 2021 Aug 2. PMID: 34339082
  • El Khoudary SR, Fabio A, Yester JW, Steinhauser ML, Christopher AB, Gyngard F, Adams PS, Morell VO, Viegas M, Da Silva JP, Da Silva LF, Castro-Medina M, McCormick A, Reyes-Múgica M, Barlas M, Liu H, Thomas D, Ammanamanchi N, Sada R, Cuda M, Hartigan E, Groscost DK, Kühn B. Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot. Int J Cardiol. 2021 Sep 15;339:36-42. doi: 10.1016/j.ijcard.2021.07.020. Epub 2021 Jul 12. PMID: 34265312
  • Basu D, Salgado CM, Bauer B, Hoehl RM, Moscinski CN, Schmitt L, Reyes-Múgica M. Histone deacetylase inhibitor Vorinostat (SAHA) suppresses micropthalmia transcription factor expression and induces cell death in nevocytes from large/giant congenital melanocytic nevi. Melanoma Res. 2021 Aug 1;31(4):319-327. doi: 10.1097/CMR.0000000000000749.PMID: 34054057
  • Schutt C, Mirizio E, Salgado C, Reyes-Mugica M, Wang X, Chen W, Grunwaldt L, Schollaert KL, Torok KS. Transcriptomic Evaluation of Juvenile Localized Scleroderma Skin With Histologic and Clinical Correlation. Arthritis Rheumatol. 2021 Oct;73(10):1921-1930. doi: 10.1002/art.41758. Epub 2021 Aug 31. PMID: 33844442
  • Mazariegos GV, Shneider BL, Shemesh E, Schady D, Melin-Aldana H, Cho SJ, Anand R, Erinjeri J, Annunziato R, Reyes-Mugica M. Approaches to Research Determination of Late Acute Cellular Rejection in Pediatric Liver Transplant Recipients. Liver Transpl. 2021 Jan;27(1):106-115. doi: 10.1002/lt.25903. Epub 2020 Nov 27. PMID: 32978871
  • Veras LV, Arnold M, Avansino JR, Bove K, Cowles RA, Durham MM, Goldstein AM, Krishnan C, Langer JC, Levitt M, Monforte-Munoz H, Rabah R, Reyes-Mugica M, Rollins MD 2nd, Kapur RP, Gosain A; American Pediatric Surgical Association Hirschsprung Disease Interest Group. Guidelines for synoptic reporting of surgery and pathology in Hirschsprung disease. J Pediatr Surg. 2019 Oct;54(10):2017-2023. doi: 10.1016/j.jpedsurg.2019.03.010. Epub 2019 Mar 21 PMID: 30935730.
  • Basu D, Salgado CM, Patel JR, Zabec J, Hoehl RM, Bauer B, Reyes-Múgica M. Pluripotency markers are differentially induced by IGF1 and bFGF in cells from patients' lesions of large/giant congenital melanocytic nevi. Biomark Res. 2019 Jan 14;7:2. doi: 10.1186/s40364-018-0152-9. eCollection 2019. PMID: 30675361.
  • Mirizio E, Marathi A, Hershey N, Ross C, Schollaert K, Salgado C, Reyes-Mugica M, Torok KS. Identifying the Signature Immune Phenotypes Present in Pediatric Localized Scleroderma. J Invest Dermatol. 2019 Mar;139(3):715-718. doi: 10.1016/j.jid.2018.09.025. Epub 2018 Oct 25. PMID: 30616925.
  • Herlitz L, Hes O, Michal M, Tretiakova M, Reyes-Múgica M, Nguyen JK, Troxell ML, Przybycin CG, Magi-Galluzzi C, McKenney JK. "Atrophic Kidney"-like Lesion: Clinicopathologic Series of 8 Cases Supporting a Benign Entity Distinct From Thyroid-like Follicular Carcinoma. Am J Surg Pathol. 2018 Dec;42(12):1585-1595. doi: 10.1097/PAS.0000000000001157. PMID: 30285996.
  • Mazer BL, Fuller MY, Lepe M, Reyes-Múgica M, Crane GM, Mukhopadhyay S, Gardner JM. Social Media in Pathology: Continuing a Tradition of Dialogue and Education. Arch Pathol Lab Med. 2018 Aug;142(8):889-890. doi: 10.5858/arpa.2018-0057-LE.PMID: 30040463.
  • Basu D, Salgado CM, Bauer B, Khakoo Y, Patel JR, Hoehl RM, Bertolini DM, Zabec J, Brzozowski MR, Reyes-Múgica M. The Dual PI3K/mToR Inhibitor Omipalisib/GSK2126458 Inhibits Clonogenic Growth in Oncogenically-transformed Cells from Neurocutaneous Melanocytosis. Cancer Genomics Proteomics. 2018 Jul-Aug;15(4):239-248. doi: 10.21873/cgp.20082. PMID: 29976629


  • Zambrano EV, DeStefano D, Reyes-Múgica M. Pediatric Germ Cell Tumors. Pathology and Biology of Cell Tumors. Nogales F, Jimémez R. Springer (submitted).


  • Alaggio R, Cree IA, Hasle H, Hill DA, Jacques TS, Jarzembowski JA, López-Terrada DH, Pfister SM, Pritchard-Jones K, Reyes-Múgica* MRM, Steliarova-Foucher E, Wesseling P. WHO Classification of Paediatric Tumours (PAED5). In preparation. Expected publication in the fall of 2021.
  • Nistal M. and Reyes-Múgica M, Editors. Development and Pathology of the Pediatric Testis (see above- 25 chapters). Series: Perspectives in Pediatric Pathology, Vol #30. A peer-reviewed publication. Society for Pediatric Pathology. Wisconsin University Press, 2017
  • Chou P, Gattuso P, Reddy VB, Reyes-Múgica M, Editors. Diagnostic Pediatric Cytopathology and Histopathologic Correlation. Cambridge University Press, 2016.