Parmjeet S. Randhawa, MD
Professor of Pathology

Dr. Randhawa
Dr. Randhawa is a member of the Division of Transplantation Pathology.

Office Location:
Division of Transplantation Pathology
Department of Pathology
UPMC-Montefiore, Room E-737
3459 5th Avenue
Pittsburgh, PA 15213
Contact Information:
Office Phone: 412-647-7646
Fax: 412-647-5237
Email: randhawapa@upmc.edu

Dr. Randhawa is one of five pathologists in the Division of Transplant Pathology. He has special expertise in the evaluation of native and kidney transplant biopsies. Difficult consult cases in this area are regularly referred to him for his opinion. He is the Course Director of a weekly multidisciplinary clinical conference on kidney allograft pathology. He is an established investigator with a long history of successful funding in the area of polyomavirus infections after kidney transplantation. He teaches medical students, residents and fellows and is regular speaker in national and international meetings focusing on renal transplantation.

Clinical Expertise

Pathologic evaluation of native, donor and allograft liver, kidney and heart, allograft small intestine and pancreas biopsies and surgical resections. He is lead patholgist for the University of Pittsburgh Kidney Transplantation Program with unmatched experience in the light microscopic, immunofluorescence and ultratructural evaluation of kidney biopsies.

Research Interests

The clinical profile of patients with BK virus infection in the renal allograft is being defined. Next generation sequencing of the T-cell receptor is being used to develop tests that can distinguish anti-viral and anti-graft immune responses. DNA sequencing of viral strains is being used to define mutations and genomic rearrangements, which may be relevant to the pathogenesis of an extremely refractory interstitial nephritis seen in these individuals. Quantitative PCR assays have been developed to measure viral load in biopsy samples and body fluids to better manage the immunosuppression levels in these patients. The interplay between host and viral immune factors in this disease is being investigated by cellular immunology, miRNA and RNAseq techniques. Drugs with antiviral activity are being screened in an in-vitro culture model for possible future use in the clinical arena. Efforts are underway to develop a mouse model of polyomavirus nephropathy that better mimics human disease than currently available models.

Specialties

Anatomic Pathology, Transplantation Pathology, Hepatic Pathology, Renal Pathology

Honors and Awards

  • American Society of Transplantation, Established Clinical Investigator Award, 2014
  • Renal Pathology Society Jacob Churg Award for outstanding contributions in Pathology, 2016
  • Chair, Transplant Diagnostics Community of Practice, Executive Committee, American Transplant Society, June 2014- May 2016
  • Member, Scientific Advisory Board, Transplant Genomics Inc, June 2015 onwards.
  • Chair Finance Committee, and Member Board of Advisors, The Renal Pathology Society, January 2014- December 2015; Member Board of Directors 2017- Present.
  • Associate Editor, American Journal of Transplantation (2012-2014).
  • Associate Editor, American Journal of Kidney Diseases (2012- present)

NIH Research

View Dr. Randhawa's NIH RePORT on nih.gov

Selected Publications

View Dr. Randhawa's publications on PubMed

  • Hirsch HH, Randhawa P: AST Infectious Diseases Community of Practice. BK polyomavirus in solid organ transplantation. Am J Transplant 2013:13 (suppl 4): 179-188.
  • Masutani K, Ninomiya T, Randhawa P. HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia. Nephrol Dial Transplant 28:3119-3126, 2013.]
  • Randhawa PS and Borislav Alexiev (equal contribution authors, Gang Zeng, Chunquing Luo, Eduardo Vazquez Martul,Cinthia B. Drachenberg,and John C. Papadimitriou. BK Virus Associated Urinary Bladder Carcinoma in Transplant Recipients: Proposed pathogenetic model. Human Pathology. 44: 908-917, 2013.
  • Mengel M, Samantha Chan, Jessie Climenhaga, Yael B Kushner, Heinz Regele, Robert B Colvin, Randhawa PS. Banff Initiative For Quality Assurance in Transplantation (BIFQUIT): Reproducibility assessment for C4d immunohistochemistry in kidney allografts. Am J Transplant. 13: 1235-45, 2013.
  • Randhawa PS. Mechanistic aspects of cell mediated rejection. In: Pathobiology of Human Disease: A Dynamic Encylopedia of Disease Mechanisms, (Linda McManus and Richard Mitchell, Editors), 2013, Elsevier Ltd, Oxford, UK.
  • Zeng Q, Sheriff KA, Ng Y-H, Zahalka S, Li Q, Ramaswami B, Randhawa P, Hoffman R, Lund FE, Chalasani G: B cells mediate chronic allograft rejection independent of antibody production. J Clin Invest. 2014, 124: 1052-56.
  • Randhawa P*, Adam B*, (*Equal Contribution Authors) Chan S, Zeng G, Regele H, Kushner Y, Colvin RB, Reeve J and Mengel M: Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of Polyomavirus Immunohistochemistry in Kidney Allografts. Am J Transplant 2014, 14: 2147-47
  • P. Randhawa, G. Zeng, M. Bueno-Fernandez, A. Salgarkar, A. Lesniak, MS, K. Isse, K. Seyb, A. Perry, I. Charles, C.Hustus, M. Huang, M.Smith, M. Glicksman. Inhibtion of large T antigen ATPase activity a potential strategy to develop anti-JCV drugs. Antiviral Research, 2014: 112: 113-119.
  • Zeng G, Huang Y, Huang Y, Lyu Z, Lesniak D, Randhawa P: Antigen-specificity of T-cell Infiltrates in Biopsies with T-cell Mediated Rejection and BK Polyomavirus Viremia: Analysis by Next Generation Sequencing. Am J Transplant. 2016, 16: 3131.
  • Gang Huang, Gang Zeng, Yuchen Huang, Bala Ramaswami, Parmjeet Randhawa. Evaluation of the Gastrointestinal Tract as a Potential Route of Primary Polyomavirus Infection in Mice. PLOS ONE, 2016, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150786
  • Xiaomu Zhao, Gang Huang, Simrath Randhawa, Gang Zeng, John Lunz, Parmjeet Randhawa. The Deleterious Effect of T-cell Infiltrates on the Allograft Kidney in the Absence of Antibody and Complement. Transplantation, 2017, 101: 395.
  • Pan L, Lyu Z, Adam A, Zeng G, Wang Z, Huang Y, Abedin Z, Randhawa P. polyomavirus BK nephropathy-associated transcriptomic signatures: a critical re-evaluation. Transplantation Direct. 2018, 4: e339.
  • Becker JU, Chang A, Nickeleit V, Randhawa P, Roufosse C. Banff borderline changes suspicious for acute T-cell mediated rejection: where do we stand? Am J Transplant, 2016, 16: 2654.
  • H. Liapis, J. Gaut, C. Klein, S. Bagnasco, E. Kraus, A.B. Farris, E. Honsova, A. Perkowska-Patasinka, D. David, J. Goldberg, M. Smith, M. Mengel, M. Haas, S. Seshan, K. Pegas,Y. Paliwal, D. Landsitel, .P. Randhawa on behalf of the Banff Working Group. Banff histopathological consensus criteria for pre-implantation kidney biopsies. 2017, 17: 140.