Joseph T. Newsome, DVM
Research Associate Professor of Pathology

Dr. Newsome is Associate Professor of Pathology and the Director of the Division of Laboratory Animal Resources (DLAR), Health Sciences and also the Director for the UPMC Hillman Cancer Center Animal Facility shared resource. He has over 31 years of coordinating preclinical and translational research with the use of animal models. He is a central reference resource for the Division of Laboratory Animal Resources and the University concerning collaborative integration between disparate research groups using a wide range of animal models. Knowledge of available programmatic animal based resources such as animal modeling, facility design and management, clinical study design, imaging, veterinary immunopathology, and veterinary surgery are key supports to the institution. This oversight of research using animal models occurs at the various branches of the University including the Six Schools of the Health Sciences, and Schools of the Arts and Sciences. His support extends but is not limited to animal model research at the Hillman Cancer Center being a member of the Cancer Virology and Colon Cancer research teams, McGowan Institute of Regenerative Medicine, the Starzl Transplant Institute, to name a few.

Office Location:
1050 South TE
DLAR
Starzl Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-648-8950
Lab Telephone: 412-864-7558
Email: jnewsome@pitt.edu

As a veterinarian with a masters and post-doctoral training in experimental pathology and director of the Division of Laboratory Animal Resources I assist, consult, educate, participate, and facilitate departmental activities when preclinical animal modeling is required.

Clinical Expertise

Laboratory animal Medicine including: Preclinical animal modeling, anesthesia, euthanasia, immunopathology, dermatopathology, comparative medicine and pathology, laboratory animal management, aquatic medicine, and surgery.

Research Interests

Expertise in immunopathology, vaccinology, device testing, dermatopathology, Papillomavirus, Polyomavirus, other infectious disease animal modeling, biocontainment, biosecurity, cancer, and virology preclinical modeling research.

NIH Research

View Dr. Newsome's NIH RePORT on nih.gov

Selected Publications

View Dr. Newsome's publications on PubMed

  • Janssen CF, Maiello P, Wright MJ Jr, Kracinovsky KB, Newsome JT. Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ketamine and Xylazine. J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):142-147. PMID: 28315642
  • Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay. mSphere. 2016 Dec 21;1(6). pii: e00334-16. doi: 10.1128/mSphere.00334-16. eCollection 2016 Nov-Dec.PMID: 28028546 .
  • Kessler MC, Jackson E, Newsome JT. Response to Protocol Review Scenario: Loose lips can sink ships-and potentially careers and institutions. Lab Anim (NY). 2016 Aug 23;45(9):328-9. . PMID: 27551799
  • Reactivation of Macacine herpesvirus 1 In Non-Human Primates: A Case Study in Risk Assessment and Institutional Response .MS. Stitt-Fischer,Kelly Hopper, Joseph Newsome, Jay Frerotte, MBA ABSA Orlando Orlando, FL. Presented at: National ABSA 2012 Oct 19 - 24. Orlando. FL.
  • Weiland L, Yothers R, Janssen C, Newsome JT. The Toy Menu: Photo Chart to Concisely Communicate Critical Details When Utilizing a Large Number of Diverse Enrichment Devices Across Multiple Species and Multiple Facilities (abstract). Journal of the American Association for Laboratory Animal Science. 2011 Sep;50(no5):Pages 722-820.
  • McDonald K, Newsome JT, Heflin D, Keller C. Using Total Quality Management Techniques to Manage Nonhuman Primate Obesity in a Multifacility Animal Program (abstract). JAALAS. 2012 Sep;51(5):676. Abstract no. P93.
  • Adusumilli S, Wagner R, Newsome J. Authority to establish housing requirements. Performance standards for housing. Lab Anim (NY) Sep 2011; 40(9): 270 PMID: 21857641. (Invited)
  • Yates BJ, Newsome J. IACUC evaluation and external scientific review. Study section's opinion matters. Lab Anim (NY) Sep 2010; 39(9): 259-60. PMID: 20729821. (Invited)
  • Yuan H, Ghim S, Newsome J, Apolinario T, Olcese V, Martin M, Delius H, Felsburg P, Jenson B, Schlegel R. An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Virology. 2007 Mar 1;359(1):28-36. PMID: 17034826
  • Kuntsi-Vaattovaara H, Verstraete FJ, Newsome JT, Yuan H Resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papillomavirus vaccine.. Vet Comp Oncol. 2003 Mar;1(1):57-63. doi: 10.1046/j.1476-5829.2003.00005.x. PMID: 19379331
  • Gokhale PC, Zhang C, Newsome JT, Pei J, Ahmad I, Rahman A, Dritschilo A, Kasid UN. Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clinical cancer research: an official journal of the American Association for Cancer Research. 2002 Nov;8(11):3611-21.PMID: 12429653.
  • Hopper K, Ness RJ, Newsome JT, Capozzi D. Retrospective Cohort Analysis of Reproductive Outcomes in a Colony of Rhesus Macaques (abstract). CONTEMPORARY TOPICS. 2003 Jul;42(4):64-123. Abstract no. PS14
  • Ghim S, Newsome J, Bell J, Sundberg JP, Schlegel R, Jenson AB. Spontaneously regressing oral papillomas induce systemic antibodies that neutralize canine oral papillomavirus. Experimental and molecular pathology. 2000 Jun;68(3):147-51. PMID: 10816383.
  • Hunter WD, Martuza RL, Feigenbaum F, Todo T, Mineta T, Yazaki T, Toda M, Newsome JT, Platenberg RC, Manz HJ, Rabkin SD. Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates. Journal of virology. 1999 Aug;73(8):6319-26. PMID: 10400723. PMCID: PMC112710.
  • Newsome JT, Portnoy LG. Neuromuscular weakness in a baboon Lab Anim Sci. 1999 Aug;49(4):349-57. PMID: 10480638
  • Leung SW, Mitchell JB, al-Nabulsi I, Friedman N, Newsome J, Belldegrun A, Kasid U Effect of L-buthionine sulfoximine on the radiation response of human renal carcinoma cell lines. Cancer. 1993 Apr 1;71(7):2276-85. PMID: 8095848
  • Sobel DO, Newsome J, Ewel CH, Bellanti JA, Abbassi V, Creswell K, Blair O. Poly I:C induces development of diabetes mellitus in BB rat. Diabetes. 1992 Apr;41(4):515-20. PMID: 1535056.
  • Iverson SJ, Kirk CL, Hamosh M, Newsome J. Milk lipid digestion in the neonatal dog: the combined actions of gastric and bile salt stimulated lipases. Biochimica et biophysica acta. 1991 Apr 24;1083(1):109-19.PMID: 2031934.