Michael A. Nalesnik, MD
Professor of Pathology

Dr. Nalensnik
Dr. Nalesnik is a member of the Division of Transplantation Pathology.
Office Location:
Division of Transplantation Pathology
Department of Pathology
UPMC Montefiore, Room E-738
3459 5th Avenue
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-647-2094
Fax: 412-647-5237
Email: nalesnikma@upmc.edu


  • MD - UMDNJ Rutgers Medical School, 1977

Clinical Expertise

Dr. Nalesnik has over 30 years of experience in transplantation pathology covering all organs and remains an active service pathologist. He has made contributions in the area of posttransplant lymphoproliferative disorders and recently headed a UNOS-based initiative to establish a systematic manner of dealing with the problem of transmission risk of organ donor-associated malignancy.

Research Interests

In collaboration with Drs. G. Michalopoulos, J. Luo and others, we are examining the distribution and associations of several proteins (LSP1, PTPRD) that we recently described as being dysregulated in hepatocellular carcinoma. This may allow for the development of correlative diagnostic approaches to define subsets of patients with HCC that would benefit from specific forms of therapy.

Selected Publications

View Dr. Nalesnik's publications on PubMed

  • Nalesnik MA: Plasma cell tumors in transplant patients. Inside Blood Commentary.: 2013 Blood. 2013 Feb 21;121(8):1247-9. doi: 10.1182/blood-2013-01-475947. PMID: 23429983.
  • Sasatomi E, Nalesnik MA, Marsh JW: Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review. World J Gastroenterol. 2013 Jul 28;19(28):4616-23. doi: 10.3748/wjg.v19.i28.4616. PMID: 23901240. PubMed Central PMCID: PMC3725389.
  • Engels EA, Castenson D, Pfeiffer RM, Kahn A, Pawlish K, Goodman MT, Nalesnik MA, Israni AK, Snyder J, Kasiske B. Cancers among US organ donors: a comparison of transplant and cancer registry diagnoses. Am J Transplant. 2014 Jun;14(6):1376-82. doi: 10.1111/ajt.12683. Epub 2014 Apr 8. PubMed PMID: 24712385.
  • O'Leary JG, Shiller SM, Bellamy C, Nalesnik MA, Kaneku H, Jennings LW, Isse K, Terasaki PI, Klintmalm GB, Demetris AJ. Acute liver allograft antibody-mediated rejection: an inter-institutional study of significant histopathological features. Liver Transpl. 2014 Jul 6. doi: 10.1002/lt.23948. [Epub ahead of print] PubMed PMID: 25045154.
  • Green M, Covington S, Taranto S, Wolfe C, Bell W, Biggins SW, Conti D, DeStefano GD, Dominguez E, Ennis D, Gross T, Klassen-Fischer M, Kotton C, LaPointe-Rudow D, Law Y, Ludrosky K, Menegus M, Morris MI, Nalesnik MA, Pavlakis M, Pruett T, Sifri C, Kaul D. Donor-derived transmission events in 2013: a report of the Organ Procurement Transplant Network Ad Hoc Disease Transmission Advisory Committee. Transplantation. 2015 Feb;99(2):282-7. doi: 10.1097/TP.0000000000000584. PubMed PMID: 25594557.
  • Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey SA, Wang J, Starzl TE. Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. Gastroenterology. 2015 Feb;148(2):379-391.e4. doi: 10.1053/j.gastro.2014.10.008. Epub 2014 Oct 13. PubMed PMID: 25448926.
  • Miller R, Covington S, Taranto S, Carrico R, Ehsan A, Friedman B, Green M, Ison MG, Kaul D, Kubak B, Lebovitz DJ, Lyon GM, Nalesnik MA, Pruett TL, Teperman L, Vasudev B, Blumberg E. Communication gaps associated with donor-derived infections. Am J Transplant. 2015 Jan;15(1):259-64. doi: 10.1111/ajt.12978. Epub 2014 Nov 6. PubMed PMID: 25376342.