Jihong Ma, MD
Research Assistant Professor of Pathology

Dr. Ma is a member of the Division of Experimental Pathology.

Office Location:
S447 BST
200 Lothrop Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-648-8072
Fax: 412-648-1916
Email: jim8@pitt.edu

Research Interests

My recent research projects include two major projects.

The first project is to explore the mechanism of aberrant HGF expression in human cancers. We mainly focus on (1) Identifying the mutation in human HGF gene and studying the mechanism of the mutation causing HGF aberrant expression in human cancers. (2) Developing a potential genetic marker in the diagnosis and prognosis of human cancers in early stage. (3) Exploring the therapeutic strategy in treatment of human cancers that harbor HGF gene mutations.

The second project is: to explore the novel mechanism that Met inhibits caspase-3 and contributes to cell survival. We found a new caspase-3 cleave site (we call it Death Defying Domain, or DDD) on Met, we mainly focus on studying the mechanism how this DDD site inhibits apoptosis and promotes cell survival.

Selected Publications

View Dr. Ma's publications on PubMed

  • Ma J, DeFrances M, Zou C, Johnson C, Ferrell R, Zarnegar R. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. J. Clin. Invest., 2009, 3: 478-479.

  • Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, Eaker A, Johnson C, Strom S, Michalopoulos G, DeFrances M & Zarnegar R. Lack of Fas antagonism by Met in human fatty liver disease. Nature Medicine, 2007, 13: 1078-1085.