Ling Lin, PhD
Research Instructor of Pathology



Office Location:
University of Pittsburgh Cancer Institute
Research Pavilion, Room G1
Hillman Cancer Center, 5117 Centre Ave.
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-623-1000
Email: lil141@pitt.edu

Education

  • PhD - Graduate School of Medicine, Chiba University. Japan, 1999
  • MSc - Zhejiang Chinese Medical University, China, 1988
  • MD- Zhejiang Chinese Medical University, China, 1982

Research Interests

Dr. Lin is interested in understanding the molecular mechanisms of the pathogenesis of cancer, and based on the basic studies, to design and explore treatment strategies for controlling the malignancies. Current research focus is to discover driving genetic aberrations in breast and ovarian cancers and develop novel therapeutics and predictive biomarkers.

Selected Publications

View Dr. Lin's complete bibliography on PubMed
  • Lin L, Zhi XL, Wang H, Bin G, Kallakury B, Krithika B, Cahn K, Yuriy G, Wu Y, Marshall JL and He AR. (2019) Mechanistic analysis of liver inflammation in mice with heterozygous lose of SPTBN1. Theranostics (In Revision).
  • Zhi X, Lin L, Yang S, Bhuvaneshwar K, Wong H, Gusev Y, Kallakury B, Shivapurkar N, Cahn K, Tian X, Marshall JL, Byers SW, and He AR. (2014) βII-spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling via regulation of Wnt inhibitor kallistatin. Hepatology. Oct 12. doi: 10.1002/hep.27558.
  • Lin L, Yao Z, Bhuvaneshwar K, Gusev Y, Yang S, Jogunoori W, Mishra L, and He AR. (2014) Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC Through cAMP-Response Element-Binding Proteins ATF3 and CREB2. Carcinogenesis. 35(11):2393-2403
  • Zhang JH, Panicker L, Seigneur EM, Lin L, House CD, Morgan W, Chen WC, Mehta H, Haj-Ali M, Yu ZX and Simonds WF. (2010) Cytoplasmic polyadenylation element binding protein is a conserved target of the tumor suppressor gene HRPT2/CDC73. Cell Death & Differentiation. 17(10): 1551-1565.
  • Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, Zasloff M, Marshall JL, Shetty K, Johnson L, Mishra L, He AR. (2009). The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF- signaling. Oncogene, 28: 961-972.
  • Lin L, Zhang JH, Panicker L and Simonds WF. (2008). The parafibromin tumor supperssor protein inhibits cell proliferation by repressio of the c-myc proto-oncogene. Proc Natl Acad Sci USA., 105 (45): 17420-17425.
  • Lin L, Czapiga M, Nini L, Zhang JH and Simonds WF. (2007). Nuclear localization of the parafibromin tumorsuppressor protein implicated in parathyroid cancer and the hyperparath-yroidism-jaw tumor syndrome enhances its pro-apoptotic function. Molecular Cancer Research. 5 (2): 183-193.
  • Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A and Koseki H. (2005). topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in cell growth suppression and apoptotic response to DNA damage. Oncogene. 24: 3385-3396.