Dong Hu, PhD
Research Instructor

Dr. Hu is a member of the Division of Experimental Pathology.

Office Location:
Rangos Research Center
Floor 5, Bay 14
4410 Penn Avenue
Pittsburgh, PA 15213
Contact Information:
Telephone: 412-692-9406


  • PhD - Chinese Academy of Sciences and Peking Union Medical College, Beijing, 2005
  • MD - Chinese Academy of Sciences, Beijing, 2001

Research Interests

Signal transduction including Wnt, TGF-β, ER and NF-κB in carcinogenesis; Cell Cycle; Protein post-translational modification

Selected Publications

View Dr. Hu's publications on PubMed

  1. Hu D, Zhou Z, Davidson NE, Huang Y, Wan Y. Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. J. Biol. Chem., 2012; 287(17): 13584-97. PMID: 22389506
  2. Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K. Critical and reciprocal regulation of KLF4 and SLUG in TGFβ-initiated prostate cancer EMT. Mol. Cell Biol., 2012; 32(5): 941-53. PMID: 22203039
  3. Hu D, Qiao X, Wu G, Wan Y. The emerging role of APC/C-Cdh1 in development. Semin. Cell Dev. Biol., 2011; 22(6): 579-85. PMID: 21497201
  4. Hu D, Wan Y. Regulation of Kruppel-like factor 4 by the Anaphase Promoting Complex pathway is involved in TGF-β Signaling. J. Biol. Chem., 2011; 286(9): 6890-901. PMID: 21177849
  5. Hu D*, Liu W*, Wu G, Wan Y. Nuclear translocation of Skp2 facilitates its destruction in response to TGF-β signaling. Cell Cycle, 2011; 10(2): 285-92. (* equal contribution) PMID: 21212736
  6. Benavides MA, Hu D, Baraoidan MK, Bruno A, Du P, Lin S, Yang W, Bland KI, Grizzle WE, Bosland MC. L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells. J Cancer Res. Clin. Oncol., 2011; 137(3): 441-53. PMID: 20454975