Yvonne S. Eisele, PhD
Assistant Professor of Medicine

Dr. Eisele
Dr. Eisele is a member of Department of Medicine.

Office Location:
Aging Institute
562 Bridgeside Point 1
100 Technology Drive
Pittsburgh, PA 15219

Contact Information:
Office Telephone: 412-383-4438
Email: eiseley@pitt.edu

Research Interests

Research in the Eisele laboratory focuses on amyloid disorders like Alzheimer's disease and cardiac transthyretin-related amyloidosis that are caused by misfolding and aggregation of specific proteins. We characterize the protein aggregates that cause these diseases and delineate the molecular mechanisms that lead to disease progression and tissue degeneration. Our goal is to gain insights that will facilitate earlier diagnosis and inform the development of novel therapeutics. Experimentally, we use biochemical, histological, molecular, and cell biological methods in combination with model organisms and patient samples (tissue and blood samples).

Our laboratory is part of the Aging Institute (https://ai.dom.pitt.edu), the Vascular Medicine Institute (https://www.vmi.pitt.edu), the Center for Protein Conformational Disorders (https://www.proteindiseasecenter.pitt.edu) and the Multidisciplinary Cardiac Amyloidosis Center (https://cardiacamyloidosis.pitt.edu). We collaborate closely with the clinical team of the Amyloidosis Center, and are dedicated to translating basic research findings into benefits for patients.

Selected Publications

View Dr. Eisele's publications on PubMed

  • Targeting protein aggregation for the treatment of degenerative diseases. Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW.Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. PMID: 26338154 Free PMC article. Review.
  • Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Eisele YS, Duyckaerts C.Acta Neuropathol. 2016 Jan;131(1):5-25. doi: 10.1007/s00401-015-1516-y. Epub 2015 Dec 29. PMID: 26715565 Review.
  • Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M.Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. doi: 10.1073/pnas.0903200106. Epub 2009 Jul 21. PMID: 19622727 Free PMC article.
  • Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M.Science. 2010 Nov 12;330(6006):980-2. doi: 10.1126/science.1194516. Epub 2010 Oct 21.PMID: 20966215 Free PMC article.