Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -
Faculty and Their Research Interests

  • Wendy M. Mars, PhD, Director
    - The roles of hepatocyte growth factor (HGF), IL-6, and elements of the plasminogen activator system in normal tissue regeneration, type 2 diabetes, fatty liver, and cirrhosis.
  • Jonathan K. Alder, PhD
    - Telomeres in human health and disease.
  • Stephen F. Badylak, DVM, PhD, MD
    - Tissue engineering and regenerative medicine.
  • Yaacov Barak, PhD
    - Placenta and adipose tissue .
  • Michael J. Becich, MD, PhD
    - Pathology informatics.
  • Aaron W. Bell, PhD, Assistant Professor
    - Understanding the role of transcription factors in control and regulation of liver growth, regeneration, differentiation and carcinogenesis.
  • Sarah Berman, MD, PhD
    - The role of mitochondria in neurodegenerative diseases, particularly Parkinson's disease.
  • Timothy R. Billiar, PhD
    - Regulation and function of inducible nitric oxide synthase.
  • Harry C. Blair, MD
    - Bone physiology and pathology.
  • Bryan Brown, PhD
    - Inductive, Scaffold Based Regenerative Medicine, Host Innate Immune Interactions in Tissue Engineering and Regenerative Medicine.
  • Grant Carl Bullock, MD, PhD
    - Hematopathology, Molecular Hematopathology, Hematopoiesis, Iron Metabolism.
  • J. Richard Chaillet, MD, PhD
    - Epigenetic inheritance in mammalian species.
  • Stephen Y. Chan, MD, PhD
    - The molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH).
  • Yuan Chang, MD
    - Viral oncogenesis.
  • Charleen T. Chu, MD, PhD
    - Neurodegeneration, neuroprotection and mitochondrial homeostasis; Parkinson's disease, Alzheimer's disease, Frontotemporal dementia; ophthalmic pathology.
  • Paula R. Clemens, MD
    - Pathogenesis of inherited muscular dystrophies, inflammatory myopathies, and cancer cachexia.
  • Lan G. Coffman, MD, PhD
    - Investigating the role of the stromal microenvironment on ovarian cancer initiation, metastasis and treatment resistance.
  • Marie C. DeFrances, MD, PhD
    - PI3K signaling mechanisms in hepatocytes.
  • Anthony J. Demetris, MD
    - The role of inflammatory cytokines and growth factors in the development of cirrhosis & tolerance induction and chronic tissue rejection.
  • Steven F. Dobrowolski, PhD
    - Intoxicating type inborn errors of metabolism: genetics, genomic assessment to identify genetic modifiers of the primary phenotype(s), and the role of epigenetic modification in disease presentation.
  • H. Henry Dong, PhD
    - Insulin resistance to diabetic dyslipidemia and insulin replacement.
  • Chris Donnelly, PhD
    - the molecular pathogenesis of neurodegeneration and aging.
  • Albert D. Donnenberg, PhD
    - Identification of therapeutic targets on cancer stem cells.
  • Anette U. Duensing, MD
    - New therapeutic strategies for gastrointestinal stromal tumors (GIST) and other sarcomas.
  • Andrew W. Duncan, PhD
    - Liver development, homeostasis and regeneration.
  • Toren Finkel, MD, PhD
    - Mitochondrial function, cellular metabolism, oxidative stress, and aging.
  • Ira J. Fox, MD
    - Experimental therapies for liver disease.
  • Mark T. Gladwin, MD
    - Pulmonary hypertension and pulmonary complications of sickle cell disease.
  • Delphine Gomez, PhD
    - The functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis.
  • Elena A. Goncharova, PhD
    - The molecular and cellular mechanisms of pulmonary arterial hypertension with specific focus on mTOR and HIPPO signaling networks.
  • Hun-Way Hwang, MD, PhD
    - mRNA regulation in both physiologic and disease scenarios with a special emphasis on 3-prime UTR-mediated regulation.
  • John M. Kirkwood, MD
    - To develop improved therapy for inoperable advanced melanoma.
  • Corrine Kliment, MD, PhD
    - COPD, Epithelial biology, airway and ciliary function, mitochondrial biology.
  • Scott Kulich, MD, PhD
    - the interaction between oxidative neurotoxins and intracellular signal transduction.
  • Robert Lafyatis, MD
    - Pathogenesis of systemic sclerosis, and its skin and pulmonary complications.
  • Eric Lagasse, PharmD, PhD
    - Human stem/progenitor cells for liver diseases.
  • Janet S. Lee, MD
    - Pulmonary host defense and molecular pathogenesis of acute lung injury from microbial infection.
  • Hang Lin, PhD
    - The etiology and pathogenesis of osteoarthritis, and aging-associated changes in the articular cartilage.
  • Youhua Liu, PhD
    - Dissecting cellular and molecular pathways leading to chronic renal fibrosis.
  • Joseph Locker, MD, PhD
    - Control of hepatocyte cell proliferation.
  • Anna E. Lokshin, PhD
    - Identification of cancer biomarkers for screening, diagnosis, prognosis, and disease monitoring of solid tumor cancers.
  • Thomas Lozito, PhD
    - Understanding of divergent regenerative capabilities among vertebrates.
  • Peter C. Lucas, MD, PhD
    - the role of an NF- κB signaling pathway that is controlled by the "CBM signalosome".
  • Jianhua Luo, MD, PhD
    - Cancer Genomics.
  • Kacey G. Marra, PhD
    - Tissue engineering peripheral nerve repair.
  • George K. Michalopoulos, MD, PhD
    - Use the differentiated cells of the liver (hepatocytes) as models to understand the mechanisms that regulate growth of complex differentiated cells and whole organs.
  • Satdarshan P. Singh Monga, MD
    - Molecular mechanisms of liver growth and development, in health and disease.
  • Mike Morowitz, MD
    - Diet, the microbiome, and intestinal inflammation
  • Kari Nejak-Bowen, PhD
    - The cellular and molecular basis of liver injury, regeneration, and cholestatic liver disease.
  • Yuri E. Nikiforov, MD, PhD
    - Molecular mechanisms of radiation-induced carcinogenesis and chromosomal rearrangements in human cells and molecular basis of thyroid cancer.
  • Michael Oertel, PhD
    - Hepatic (stem) cell transplantation and tissue replacement in fibrotic liver.
  • Steffi Oesterreich, PhD
    - Endocrine resistance in breast cancer.
  • Zoltan Oltvai, MD, PhD
    - Systems biology.
  • Tim D. Oury, MD, PhD
    - Oxidative stress and innate immunity in pulmonary disease.
  • Julie Phillippi, PhD
    - The role perivascular progenitor cells, adventitial biology/biomechanics.
  • Jon D. Piganelli, PhD
    - Oxidative stress and free radical generation.
  • Reben Raeman, MS, PhD
    - Hepatic inflammation and fibrosis in non-alcoholic steatohepatitis (NASH).
  • Iain Scott, PhD
    - Mitochondrial metabolism and bioenergetics.
  • Melanie J Scott, MD, PhD
    - Innate immune responses after surgery, trauma, hemorrhagic shock and infection.
  • Steven D. Shapiro, MD
    - Biological functions of matrix degrading proteinases.
  • Alejandro Soto-Gutierrez, MD, PhD, Associate Director
    - Development of new technologies for liver function replacement using regenerative medicine approaches.
  • Cynthia St. Hilaire, PhD
    - The mechanisms that drive cell phenotype transitions and the interplay between extracellular matrix remodeling and vascular calcification in the context of both rare and common cardiovascular diseases.
  • Donna Beer Stolz, PhD
    - Angiogenesis and vascular function.
  • Kenichi (Ken) Tamama, MD, PhD, FCAP
    - Cellular and molecular biology of mesenchymal stem cells.
  • Roderick J. Tan, MD, PhD
    - The molecular mechanisms underlying the development of acute kidney injury and chronic kidney disease.
  • Angus W. Thomson, PhD, DSc
    - Regulatory immune cells, mTOR and transplant tolerance.
  • Bryan W. Tillman, MD, PhD
    - Novel therapies for vascular graft failure resulting from graft stenosis.
  • Ivona Vasile-Pandrea, MD, PhD
    - SIV pathogenesis in progressive and nonprogressive hosts. Immune therapies for HIV infection.
  • Nam Viet Vo, PhD
    - To understand the mechanisms of degeneration of matrix in the intervertebral discs and explore therapeutic strategies to minimize disc matrix loss.
  • Yoram Vodovotz, PhD
    - Systems approaches to the biology of shock states, host-pathogen interactions, wound healing, and chronic inflammatory diseases.
  • David Alan Vorp, PhD
    - Vascular biomechanics.
  • Xiaosong Wang, MD, PhD
    - Integrative bioinformatics, cancer genetics, molecular cancer biology, and translational studies to identify genetic aberrations and appropriate cancer targets.
  • Zhou Wang, PhD
    - Androgen action and the roles of androgens in benign and cancerous prostate growth.
  • Alan Wells, MD, DMS
    - Cell and matrix communication in tissue physiology and pathology: exploring tumor progression and wound healing from molecular interactions through organismal biology using novel engineered models with a focus on all human systems.
  • Sally E. Wenzel, MD
    - Pathobiology of asthma.
  • Clayton A. Wiley, MD, PhD
    - Pathogenesis of neurodegenerative diseases and in particular on viral induced nervous system diseases.
  • Cary Wu, PhD
    - Cell adhesion: molecular mechanism and the roles in the pathogenesis of cancer and diabetic nephropathy.
  • Dean Yimlamai, MD, PhD
    - Human liver development and injury.
  • Jian Yu, PhD
    - The molecular mechanisms of apoptosis in mammalian cells and its role in cancer therapy and carcinogenesis.
  • Reza Zarnegar, PhD
    - The analysis of hepatocyte growth factor (HGF) and HGF receptor (a protooncogene) function and their genetic regulation at the molecular level in vivo.
  • Yingze Zhang, PhD
    - The molecular and genetic basis of pulmonary and vascular diseases.