Pathology Graduate Training Program
Cellular and Molecular Pathology (CMP) -

Name:Xin He

Undergraduate Degree: BS
Undergraduate Degree Year: 1997
Undergraduate Institution: Hengyang Medical College
Undergraduate Major: Clinical Medicine

Academic Status: 3rd Year

Graduate Program: Experimental Pathology

Thesis Advisor: Marie Defrances, M.D., Ph.D.

Thesis Title/Research Topic: Role of PIK3IP1 in liver development, regeneration and gene expression

Current Research Description: The Class Ia phosphatidylinositol-3-kinases (PI3Ks) are important mediators of intracellular signaling stimulated by growth factors, hormones, cytokines, neurotransmitters and other molecules. Recently, our lab identified a new PI3K regulatory protein named PI3K Interacting Protein 1 (PIK3IP1), which can directly bind p110 catalytic subunit of PI3K and inhibit PI3K activity (2). We also elucidated that PIK3IP1 inhibits activation of Ras and the mitogen activated protein kinase (MAPK) pathway, most likely in a PI3K dependent manner. Given the evidence that both the PI3K and Ras-MAPK pathways are involved in liver development, regeneration, and tumorigenesis, we hypothesize that, by regulating these pathways, PIK3IP1 influences liver homeostasis. To test this hypothesis in vivo and in vitro, we generated liver-specific PIK3IP1 overexpressing transgenic mice and intend to carry out both in vivo and in vitro studies to test the role of PIK3IP1 in liver development, regeneration and gene expression.


Graduate Honors:


  1. Wang JG*, He X*, Wang GL, et al. Family-based associations between the Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Multiple Cardiovascular Risk Factors in Chinese. Journal of Hypertension. 2004, 22(3):487-491. (*contribute equally)
  2. Zhu DL, Wang HY, Wang GL., He X, Zhao GS. et al. A genome-wide scan for hypertension susceptibility genes in Chinese families. Journal of Hypertension. 2001,19:55-61
  3. Gao PJ, Zhang KX, Zhu DL, He X, Han ZY. et al. The Diagnosis of Liddle syndrome by genetic analysis of and subunits of epithelial sodium channel-a report of five affected family members. Journal of Hypertension. 2001, 19: 885-889
  4. He X, Zhu DL, Chu SL, et al. -adducin gene and hypertension in Chinese. Clinical and Experimental Hypertension. 2001, 23(7): 579-589
  5. He X, Wang GL, Huang W, et al. Linkage analysis of five essential hypertension candidate genes in Chinese. Journal of Human Hypertension. 2003, 17(1):69-72 Meeting abstracts:
  6. He X, Zhu D, Wang G, Zhou H, and Zhang W. Family-based associations between the angiotensin-converting-enzyme gene insertion/deletion polymorphism and multiple cardiovascular risk factors in Chinese. American Journal of Human Genetics. 2003; 73 (5): Suppl 2136.
  7. Zhang K, Zhu D, He X, Wang G, Huang W. Association of human SCN6A gene with essential hypertension in Chinese. American Journal of Human Genetics. 2003; 73 (5): Suppl 2150.
  8. Zhu D, He X, Zhang K, Zhang Y, Wang G, Huang W. Genetic variations in kynureninase gene are associated with essential hypertension in Chinese. American Journal of Human Genetics. 2003; 73 (5): Suppl 2151.