Adriana Zeevi, PhD, ABHI (D)
Professor of Pathology


Dr. Zeevi is a professor of Pathology, Surgery and Immunology, Clinical Director of the the Tissue Typing Laboratory, and a member of the Division of Transplantation Pathology.

Office Location:
Division of Transplant Pathology
Department of Pathology
W1551 Biomedical Science Tower
Pittsburgh, PA 15261

Contact Information:
Office Phone: 412-624-1073
Fax: 412-624-6666
Email: zeevi@pitt.edu

Education

  • BA - 1973, Bar-llan University, Ramat-Gan, Israel
  • MS - 1974, Bar-llan University, Ramat-Gan, Israel
  • PhD - 1979, Bar-llan University, Ramat-Gan, Israel

Clinical Expertise

My clinical expertise is in the area of Immunogenetics and Histocompatibility. I am the Clinical Director of Tissue Typing Laboratory that serves the transplant program and I provide consultation for all solid organ and bone marrow transplantation. An important aspect of my clinical expertise is to characterize the humoral sensitization and rejection in solid organ transplants. I have over 25 years of experience with immune monitoring of solid organ transplant recipients and implementation of various assays and novel approaches to evaluate the efficacy of protocols used to desensitize transplant candidates and/or to treat antibody mediated rejection in solid organ transplant recipients.

Research Interests

Despite improved immunosuppression protocols, most transplant recipients face a variety of complications. Early post-transplant is important to discriminate between infection and rejection. Drug toxicity, chronic rejection and malignancies are long-term complications. Dr. Zeevi's research interests are focused in the area of immunologic monitoring of solid organ transplant recipients:
  1. Cellular assay to determine the host immune competence and responses to recall antigens (CMV, EBV and other)
  2. Evaluation of T helper cell function and cytokine profile upon stimulation with donor-specific alloantigen.
  3. The impact of cytokine gene polymorphism in solid organ transplantation and its predictive value for individualized immunosuppressive protocols
  4. The role of HLA-specific and non-HLA antibodies in solid organ transplantation.
  5. The implementation of novel Luminex platform C1q binding assay to detect complement fixing donor-specific anti HLA antibodies in patient sera and to correlate this functional assay with clinical outcomes including the efficacy of protocols used to desensitize transplant candidates and/or to treat antibody mediated rejection in solid organ transplant recipients.

Certifications

DIPLOMAT, Laboratory Specialty of Histocompatibility Testing

Selected Publications

View Dr. Zeevi's publications on PubMed

  1. Abu-Elmagd KM, Costa G, BondGJ, Wu T, Murase N, Zeevi Adriana, Simmons R, Soltys K, Sindhi R, Stein W, Demetris A, Mazariegos G. Evolution of the immunosuppressive strategies for the intestinal and multvisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int 2009; 22: 96-19
  2. Husain S, Pietrangeli CE, Zeevi Adriana. Delayed onset CMV disease in solid organ transplant recipients. Transplant Immunology. 2009; 21: 1-9
  3. Kobashigawa J, Mehra M, West L, Kerman R, George J, Rose M, Zeevi A, Reinsmoen N, Patel J, Reed EF; Consensus Conference Participants. Report from a consensus conference on the sensitized patient awaiting heart transplantation. J Heart Lung Transplant. 2009; 28: 213-25
  4. Batal I, Franco ZM, Shapiro R, Basu A, Tan H, Kayler L, Zeevi Adriana, Morgan C, Randhawa P. Clinicopathologic analysis of patients with BK viruria and rejection –like graft dysfunction. Hum Pathol. 2009; 40: 1312-9
  5. Ramawami B, Popescu I, Macedo C, Metes D, Bueno M, Zeevi Adriana, Shapiro R, Viscidi R, Randhawa PS. HLA-A01-A03-and A024-binding nanomeric epitopes in polyomavirus BK large T-antigen. Hum Immunol 2009; 70: 722-8
  6. Shapiro R, Zeevi Adriana. Donor-specific reactivity and Th1 cytokines-implications for immunologic monitoring. Transplan 2009; 10: 87-1436
  7. Zeevi Adriana, Lunz J3rd, Shapiro R, Randhawa P, Mazarigos G, Webber S, Girnita A. Emerging role of donor-specific anti-human leukocyte antibody determination for clinical management after solid organ transplantation. Hum Immunol 2009; 70: 645-50
  8. Girnita DM, Webber SA, Brooks MM, Ferrell R, Girnita AL, Burckart GJ, Chinnock P, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel D, Zeevi Adriana. Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms. Transplantation 2009; 87: 1801-8
  9. Husain S, Raza K, Pilewski JM, Zaldonis DM Crespo M, Toyda Y, Shutt K, Spichty K, Bentlejewski C, Pakstis DL, Carey ME, McCurry KR, Zeevi Adriana. Experience with immune monitoring in lung transplant recipients: correlation of low immune function with infection. Transplantation 2009; 27: 1852-7
  10. Husain S, Raza K, Pilewski JM, Zaldonis DM Crespo M, Toyda Y, Shutt K, Spichty K, Bentlejewski C, Pakstis DL, Carey ME, McCurry KR, Zeevi Adriana. Experience with immune monitoring in lung transplant recipients: correlation of low immune function with infection. Transplantation 2009; 27: 1852-7
  11. Macedo C, Zeevi Adriana, Bentlejewski C, Popescu I, Green M, Rowe D, Smith L, Webber S, Metes D. The impact of EBV loads on T-cell immunity in pediatric thoracic transplant recipients Transplantation 2009; 88: 123-8
  12. Macedo C, Orkis EA, Popescu I, Elinoff BD, Zeevi Adriana, Shapiro R, Lakkis FG, Metes D. Contribution of naïve and memory T-cell populations to the human alloimmune response. Am J Transplant. 2009; 9: 2057-66
  13. Gupta A, Kumar CA, Ningappa M, Sun Q, Higgs BW, Snyder S, Zeevi Adriana, Thomson AW, Mazariegos GV, Sindhi R. Elevated myeloid: plasmacytoid dendritic cell ratio associates with late but not early, liver rejection in children induced with rabbit anti-human thymocyte globulin. Transplantation 2009; 88: 589-94
  14. Abu-Elmagd KM, Costa G, Bond GJ, Soltys K, Sindhi R, Wu T, Koritsky DA, Schuster B, Martin L, Cruz RJ, Murase N, Zeevi Adriana, Irish W, Ayyash MO, Matarese L, Humar A, Mazariegos G. Five hundred intestinal and multivisceral transplantations at a single center: Major advances with new challenges. Ann Surg.(in press)
  15. Batal I, Zainah H, Stockhausen S, Basu A, Tan H, Shapiro R, Zeevi Adriana, Girnita A, Randhawa P. The significance of renal C4d staining in patients with BK viruria, viermia, and nephropathy. Mod Pathol 2009; 22:1468-76
  16. Lomago J, Jelenik L, Zern D, Howe J, Martell J, Zeevi Adriana, Duquesnoy RJ. How did a patient who types for HLA-B*4403 develop antibodies that react with HLA-B*4402? Hum Immunol ; 2010 71: 176-8
  17. Girnita A, Mazariegos GV, Castellaneta A, Reyes J, Bentlejewski C, Thomson AW, Zeevi A. Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies. Hum Immunol; 2010; 71: 274-6
  18. Ohmann EL, Burckart GJ, Brooks MM, Chen Y, Pravica V, Girnita DM, Zeevi Adriana, Webber SA. Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients. J Heart Lung Transplant: 2010; 29: 509-16
  19. Gupta A, Ashokkumar C, Ningappa M, Sun Q, Higgs BW, Snyder S, Johnson M, Zeevi Adriana, Abu-Elmagd KM, Thomson AW, Mazariegos GV, Sindhi R. Elevated myeloid: plasmacytoid dendritic cell ratio associates with early acute cellular rejection in pediatric small bowel transplantation. Transplantation 2010 15: 55-60
  20. Zeevi Adriana, Lunz JG 3rd. Human leukocyte antigen antibodies in liver retransplantation Liver Transplant 2010: 16: 259-61
  21. Jayaram A, Zeevi Adriana, Bentlejewski C, Lin Y, Michaels MG. Immune response of young children using ATP-based Cylex assay: A brief report. Pediatr Transplantation 2010: 14:664–666.
  22. Batal I, Zeevi Adriana, Lunz JG 3RD, Aggarwal N, Shapiro R, Randhawa P, Girnita A. Antihuman leukocyte antigen-specific antibody strength determined by complement-dependent or solid –phase assays can predict positive donor-specific crossmatches. Arch Pathol Lab Med. 2010: 134: 1534-40
  23. Bon JM, Zhang Y, Duncan SR, Pilewski JM, Zaldonis D, Zeevi Adriana, McCurry KR, Greenspan SL, Sciurba FC. Plasma inflammatory mediators associated with bone metabolism in COPD. COPD 2010 : 7: 186-91
  24. Sindhi R, AsholLumar C, Mazariegos G, Nayyar N, Ningappa M, Soltys K, Bond G, Sunw Q, Humar A, Abu-Elmagd, Zeevi Adriana. Immune monitoring in small bowel transplantation. Curr Opin Organ Transplant 2010: 15: 349-56
  25. Shapiro R, Zeevi Adriana. Why does combined liver and kidney transplantation confer an immunologic benefit to a kidney? Pediatr Transplant 2010: 14: 349-56
  26. Ohmann EL, Burckart GJ, Chen Y, Pravica V, Brooks MM, Zeevi Adriana, Webber SA. Inosaine 5’-monophosphate dehydrogenase 1 haplotypes and association with mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients. Pediatr Transplant 2010: 14: 891-5
  27. Ohmann EL, Brooks MM, Webber SA, Girnita DM, Ferrell RE, Burckart GJ, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi Adriana. Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients. J Heart Lung Transplant 2010: 29: 1342-51
  28. Ashokkumar C, Bentlejewski C, Sun Q, Higgs BW, Snyder S, Mazariegos GV, Abu-Elmagd K, Zeevi Adriana, Sindhi R. Allospecific CD154+ B cells associate with intestine allograft rejection in children. Transplantation 2010: 15: 1226-31
  29. Batal I, Zeevi Adriana, Lunz JG 3RD, Aggarwal N, Shapiro R, Randhawa P, Girnita A. Antihuman leukocyte antigen-specific antibody strength determined by complement-dependent or solid-phase assays can predict positive donor-specific crossmatches. Arch Pathol Lab Med 2010: 134: 1534-40
  30. Xue J, Gochuico BR, Alawad AS, Feghali-Bostwick CA, Noth I, Nathan SD, Rosen GD, Rosas IO, Dacics S, Fuhrman CR, Cuenco KT, Smith MA, Jacobs SS, Zeevi Adriana, Morel PA, Pilewski JM, Valentine VG, Gibson KF, Kaminski N, Sciurba FA, Zhang Y, Duncan SR. The HLA class II allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. PLos One. 2011 23: 6-e14715
  31. Kobasgigawa, J Crespo-Leiro MG, Ensminger SM, Reichenspurner H, Angelini A, Berry G, Burke M, Czer L, Hiemann N, Kfoury AG, Mancini D, Mohacsi P, Patel J, Pereira N, Platt JL, Reed F, Reinsomen N, Rodriguez ER, Rose ML, Russell SD, Suciu-Foca N, Tallaj J, Taylor DO, Van Bakel A, West L , Adriana Zeevi, Zuckermann A; Consensus Conference Participant. Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 2011: 30: 252-69
  32. Mitsani D, Nyguyen MH, Girnita DM, Spichty K, Kwak EJ, Silveria FP, Toyoda Y, Pilewski JM, Crespo M, Bhama JK, Abdel-Massih R, Zaldonis D, Zeevi Adriana, Clancy CJ. A polymorphism linked to elevated levels of interferon-y is associated with increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center. J Heart Lung Transplant 2011: 30: 523-9