Clayton A. Wiley, MD, PhD
PERF Professor of Pathology

Dr. Wiley
Dr. Wiley is Director of the Division of Neuropathology. In addition to clinical sign out, Dr. Wiley directs the Neuropathology fellowship program and runs an NIH funded research program studying neuroinflammation and viral encephalitis in particular.

Office Location:
S701.4 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-624-0764
Fax: 412-624-5610
Email Address:


  • MD - University of California, San Diego, 1981
  • PhD - University of California, San Diego, 1981


Board certified in AP and NP 1985



Awards and Honors

Fellow American Association for Advancement of Science

Clinical Expertise

Dr. Wiley is board certified in Neuropathology with specific expertise in infectious disease.

Research Interests

Dr. Wiley's research concentrates on the pathogenesis of neurodegenerative disorders and in particular on viral induced nervous system diseases. Viruses damage the nervous system either by direct infection of neural cells or by secondary effects of an immune response. In recent years his studies have focused on central nervous system lentiviral, arboviral, enteroviral and influenzal infections and have pioneered the use of molecular and imaging techniques to quantitatively assess viral burden and neuroinflammation. This same technology is now being applied to quantify neurological damage and the immune response. In addition to human studies of AIDS and Alzheimer’s dementia, Dr. Wiley’s lab uses H5N1 and H1N1 infected mice, ferrets and non-human primates to model viral encephalitis. Using MRI, PET and laser confocal microscopy they are investigating the evolution of the innate immune response, extracellular matrix degradation and macrophage trafficking in mediating neurological disease. Recent studies have focused on the role of immunization to modulate infectious (West Nile Virus, Influenza, Rift Valley Fever Virus, Human Parechovirus) and non-infectious (Alzheimer’s) neurological disease. Through extensive collaborations with neuroscientists throughout the Pittsburgh community, Dr. Wiley leads a team studying the interactions between aging and lentiviral infection on physiology and pathology of the nervous system.

NIH Research

View Dr. Wiley's NIH RePORT on

Selected Publications

View Dr. Wiley's publications on PubMed

  • Clark KH, Wiley CA and Bradberry CW: Psychostimulant abuse and neuroinflammation: Emerging evidence of their interconnection. (2013) Neurotoxicity Research 23:174-188. PMID: 22714667.
  • Wiley CA and Cysique LA: The cost of silencing HIV in the brain. Neurology 80:1363-1364, 2013. doi: 10.1212/WNL.0b013e31828c3077. PMID: 23486870.
  • Venneti S, Lopresti BJ, and Wiley CA: Molecular imaging of microglia/macrophages in the brain. Glia 61:10-23, 2013. doi: 10.1002/glia.22357. Epub 2012 May 21. PMCID: PMC3580157.
  • Bissel SJ, Wang G, Carter DM, Crevar CJ, Ross TM, Wiley CA. H1N1, but Not N3N2, Influenza A Virus Infection Protects Ferrets from H5N1 Encephalitis. J Virol (2014) 88(6):3077-3091. PMCID: PMC3957958.
  • Bissel SJ, Winkler CC, DelTondo J, Wang G, Williams K, and Wiley CA. Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins. Neuropathology (2014) 34, 429–437 Apr 7. doi: 10.1111/neup.12121. PMCID: PMC4188796.
  • Wiley CA, Bonneh-Barkay D, Dixon CE, Lesniak A, Wang G, Bissel SJ, and Kochanek PM: Role for mammalian chitinase 3-like protein 1 in traumatic brain injury. Neuropathology (2015) 35:95-106. PMID: 25377763.
  • Mardekian SK, Fortuna D, Nix A, Bhatti T, Wiley CA, Flanders A, Urtecho J, Sloane J, Ahmad J, and Curtis MT. Severe Human Parechovirus Type 3 Myocarditis and Encephalitis in an Adolescent with Hypogammaglobulinemia. International Journal of Infectious Diseases 2015.doi: 10.1016/j.ijid.2015.05.008. PMID: 25975649.