Anthony J. Demetris, MD
Starzl Professor of Liver and Transplant Pathology


Dr. Demetris is the Director of the Division of Liver and Transplantation Pathology and also the Research Histology Shared Resource Laboratory of the University of Pittsburgh. He is a member of the McGowan Institute for Regenerative Medicine, Chairman of the IRB Risk Management Committee, and a member of the Thomas E. Starzl Transplant Institute IT Steering Committee.

Office Location:
Division of Transplantation Pathology
Department of Pathology
UPMC-Montefiore, Room E-741
3459 5th Avenue
Pittsburgh, PA 15213

Contact Information:
Office Telephone: 412-647-2072
Lab Telephone: 412-624-6605
Fax: 412-647-2084
Email: demetrisaj@upmc.edu

Education

  • BS - 1978, Rensselaer Polytechnic Institute
  • MD - 1982, University of Pittsburgh

Clinical Expertise

  • Native and allograft liver, kidney, and heart pathology. Autoimmune and inflammatory disorders, liver and biliary tract cancers.

Research Interests

Dr. Demetris' interests include the: 1) immunobiology of tolerance induction and chronic rejection; 2) the role of cytokines in growth control of biliary epithelium; and 3) digital pathology for enhancing liver and transplantation pathology and research. Current translational and basic research projects include: a) study and development of experimental animal and human protocols to understand mechanisms of spontaneous operational tolerance to solid organ allografts; b) biliary epithelial cell biology and chronic liver disease; and c) use of multiplexing and high resolution whole slide imaging in studying biological phenomena, including tolerance induction and biliary pathobiology.

Certifications

  • Medical License - Commonwealth of Pennsylvania, Department of State, Bureau of Professional and Occupational Affairs - 1984
  • The American Board of Pathology, Combined Anatomical and Clinical Pathology - 1987

Awards and Honors

  • International Liver Transplantation Society, Distinguished Service Award – 2012
  • PEW Scholar Program Candidate, University of Pittsburgh – 1987
  • Resident Research Award, Pittsburgh Academy of Medicine – 1984, 1985
  • Alpha Omega Alpha (Medical Honor Society) – 1982

Selected Publications

View Dr.Demetris' publications on PubMed

  1. Isse K, Lesniak A, Grama K, Roysam B, Minervini MI, Demetris AJ. Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining, and Automated Image Analysis. Am J Transplant. 2012 Jan;12(1):27-37. doi: 10.1111/j.1600-6143.2011.03797.x
  2. Zhu X, Shiba H, Fung JJ, Wang LF, Arakawa Y, Irefin S, Demetris AJ, Kelly DM: The Role of the A2a Receptor Agonist, Regadenoson, in Modulating Hepatic Artery Flow in the Porcine Small-for-Size Liver Graft. J Surg Res. 2012 May 1;174(1):e37-45. Epub 2011 Oct 27.
  3. Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG: Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology. Transpl Immunol. 2012 Mar;26(2-3):113-8.
  4. Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA and Tchao NK: Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA. 2012 Jan 18;307(3):283-93.
  5. Mengel M, Sis B, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K, Cendales L, Demetris AJ, Drachenberg CB, Farver CF, Rodriguez ER, Wallace WD, Glotz D; as the Banff meeting report writing committee: Banff 2011 Meeting Report: New Concepts in Antibody-Mediated Rejection. Am J Transplant. 2012 Mar; 12(3):563-70. doi: 10.1111/j.1600-6143.2011.03926.x.
  6. Macedo C, Walters JT, Orkis EA, Isse K, Elinoff BD, Fedorek SP, McMichael JM, Chalasani G, Randhawa P, Demetris AJ, Zeevi A, Tan H, Shapiro R, Landsittel D, Lakkis FG, Metes D: Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation. Transplantation. 2012 Apr 27;93(8):813-21.
  7. Mizuguchi, Y, Specht, S, Lunz, J, Isse, K, Corbitt, N, Takizawa, T, Demetris, AJ. Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. PLOS One 2012;7(2):e32449. Epub 2012 Feb 22
  8. Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD: Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction. J Immunol. 2012 Apr 15;188(8):3804-11.
  9. Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ: SPRR2a enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity. BMC Mol Biol. 2012 Jun 25;13:20. doi: 10.1186/1471-2199-13-20.
  10. Adeyi O, Alexander G, Baiocchi L, Balasubramanian M, Batal I, Bellamy C O C, Bhan A, Bridges N, Bucuvalas J, Charlotte F, Colvin B, Czaja A, Demetris A, DeVera M, El-Monayeri MS, Feng S, Ferrell L, Fiel Maria I, Fontes P, Fung J, Haga H, Hart J, Honsova E, Hubscher S, Wesam I, Itoh T, Jhala N, Jungmann P, Khettry U, Koshiba T, Lassman C, Lerut J, Ligato S, Lunz J, Mazariegos G, McCaughan G, McClelland SA, Minervini MI, Misdraji J, Mohanakumar T, Molne J, Musat A, Nalesnik M, Nasser I, Neil D, Neuberger J, Pappo O, Petrovic L, Randhawa P, Reinholt FP, Rubin E, Ruiz P, Sagol O, Sanchez-Fueyo A, Sasatomi E, Schiano T, Sebagh M, Shaked A, Sharkey FE, Shimizu T, Sis B, Smith M, Sonzogni A, Tchao N, Thung S, Tisone G, Tsamandas A, Wernerson A, Wu T, Yilmaz F; The Banff Working Group on Liver Allograft Pathology. Importance of liver biopsy findings in immunosuppression management: Biopsy monitoring and working criteria for patients with operational tolerance (OT). Liver Transpl. Oct;18(10):1154-70, 2012.
  11. Pantanowitz L, Wiley CA, Demetris A, Lesniak A, Ahmed I, Cable W, Contis L, Parwani AV: Experience with multimodality telepathology at the University of Pittsburgh Medical Center. J Pathol Inform. 2012;3:45. doi: 10.4103/2153-3539.104907. Epub 2012 Dec 20.
  12. Schneeberger S, Gorantla VS, Brandacher G, Zeevi A, Demetris AJ, Lunz JG, Metes DM, Donnenberg AD, Shores JT, Dimartini AF, Kiss JE, Imbriglia JE, Azari K, Goitz RJ, Manders EK, Nguyen VT, Cooney DS, Wachtman GS, Keith JD, Fletcher DR, Macedo C, Planinsic R, Losee JE, Shapiro R, Starzl TE, Lee WP. Upper-Extremity Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression. Ann Surg. 2013 Feb;257(2):345-51. doi: 10.1097/SLA.0b013e
  13. Isse K, Lesniak A, Grama K, Maier J, Specht S, Castillo-Rama M, Lunz J, Roysam B, Michalopoulos G, Demetris AJ: Pre-existing epithelial diversity in normal human livers: A tissue-tethered cytometric analysis in portal/periportal epithelial cells. Hepatology. 2013 Apr;57(4):1632-43. doi: 10.1002/hep.26131.
  14. Corbitt N, Kimura S, Isse K, Specht S, Chedwick L, Rosborough BR, Lunz JG, Murase N, Yokota S, Demetris AJ: Gut Bacteria Drive Kupffer Cell Expansion via MAMP-Mediated ICAM-1 Induction on Sinusoidal Endothelium and Influence Preservation-Reperfusion Injury after Orthotopic Liver Transplantation. Am J Pathol. 2013 Jan;182(1):180-91 doi: 10.1016/j.ajpath.
  15. Zhang M, Ueki S, Kimura S, Yoshida O, Castellaneta A, Ozaki KS, Demetris AJ, Ross M, Vodovotz Y, Thomson AW, Beer Stolz D, Geller DA, Murase N: Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology. 2012 Nov 26. doi: 10.1002/hep.26129. [Epub ahead of print] Hepatology. 2013 Apr;57(4):1585-96. doi: 10.1002/hep.26129.
  16. Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG: Allograft Outcomes in Outbred Mice. Am J Transplant. 2013 Mar;13(3):580-8. doi: 10.1111/ajt.12056.
  17. Demetris AJ, Isse K: Tissue biopsy monitoring of operational tolerance in liver allograft recipients. Curr Opin Organ Transplant. 2013 Jun;18(3):345-53.
  18. Specht S, Isse K, Nozaki I, Lunz JG 3rd, Demetris AJ: SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis. 2013 Oct;30(7):877-90.
  19. Ezzelarab MB, Zahorchak AF, Lu L, Morelli AE, Chalasani G, Demetris AJ, Lakkis FG, Wijkstrom M, Murase N, Humar A, Shapiro R, Cooper DK, Thomson AW: Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates. Am J Transplant. 2013 Aug;13(8):1989-2005. doi: 10.1111/ajt.12310.
  20. Sebagh M, Castillo-Rama M, Azoulay D, Coilly A, Delvart V, Allard MA, Dos Santos A, Johanet C, Roque-Afonso AM, Saliba F, Duclos-Vallée JC, Samuel D, Demetris AJ: Histologic Findings Predictive of a Diagnosis of De novo Autoimmune Hepatitis After Liver Transplantation in Adults. Transplantation. 2013 Oct 15;96(7):670-8. doi: 10.1097/TP.0b013e31829eda7f.
  21. Castillo-Rama, M, Sebagh, M, Sasatomi, E, Randhawa, P, Isse, K, Salgarkar, A.D, Ruppert, K, Humar, A, Demetris, A.J: "Plasma cell hepatitis" in Liver Allografts: Identification and Characterization of an IgG4-rich Cohort. Am J Transplant. 2013 Nov;13(11):2966-77. doi: 10.1111/ajt.12413.
  22. Nachmany I, Dvorchik I, Devera M, Fontes P, Demetris A, Humar A, Marsh JW: A validated model for predicting outcome after liver transplantation: implications on transplanting the extremely sick. Transpl Int. Transpl Int. 2013 Nov;26(11):1108-15. doi: 10.1111/tri.12171.
  23. Mizuguchi Y, Isse K, Specht S, Iii JG, Corbitt N, Takizawa T, Demetris AJ: Small Proline Rich Protein 2a in Benign and Malignant Liver Disease. Hepatology. 2014 Mar;59(3):1130-43.
  24. O'Leary JG, Kaneku H, Demetris AJ, Marr JD, Shiller SM, Susskind BM, Tillery GW, Terasaki PI, Klintmalm GB.Antibody-mediated rejection as a contributor to previously unexplained early liver allograft loss. Liver Transpl. 2014 Feb;20(2):218-27. doi: 10.1002/lt.23788. Epub 2014 Jan 2.
  25. Haas M, Sis B, Racusen LC, Solez K, Glotz D, Colvin RB, Castro MC, David DS, David-Neto E, Bagnasco SM, Cendales LC, Cornell LD, Demetris AJ, Drachenberg CB, Farver CF, Farris AB 3rd, Gibson IW, Kraus E, Liapis H, Loupy A, Nickeleit V, Randhawa P, Rodriguez ER, Rush D, Smith RN, Tan CD, Wallace WD, Mengel M; as the Banff meeting report writing committee: Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant. 2014 Feb;14(2):272-83. doi: 10.1111/ajt.12590.
  26. O'Leary JG, Demetris AJ, Friedman LS, Gebel HM, Halloran PF, Kirk AD, Knechtle SJ, McDiarmid SV, Shaked A, Terasaki PI, Tinckam KJ, Tomlanovich SJ, Wood KJ, Woodle ES, Zachary AA, Klintmalm GB: The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation. Am J Transplant. 2014 Apr;14(4):779-87.
  27. Neil DA, Demetris AJ. Digital pathology services in acute surgical situations. Br J Surg. 2014 Sep;101(10):1185-6. doi: 10.1002/bjs.9576.
  28. O'Leary JG, Shiller SM, Bellamy C, Nalesnik MA, Kaneku H, Jennings LW, Isse K, Terasaki PI, Klintmalm GB, Demetris AJ: Acute liver allograft antibody-mediated rejection: an inter-institutional study of significant histopathological features. Liver Transpl. 2014 Oct;20(10):1244-55. doi: 10.1002/lt.23948.
  29. Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey SA, Wang J, Starzl TE: Liver-Specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steatohepatitis and Hepatocellular Carcinoma in Mice. Gastroenterology. 2015 Feb;148(2):379-391.e4. doi: 10.1053/j.gastro.2014.10.008.
  30. Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, Soltys K, Shiva S, Paranjpe S, Sadowsky D, Barclay D, Zamora R, Stolz D, Demetris A, Michalopoulos G, Marsh JW. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant. 2015 Feb;15(2):381-94.
  31. IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15/IL-15R? Production. Yokota S, Yoshida O, Dou L, Spadaro AV, Isse K, Ross MA, Stolz DB, Kimura S, Du Q, Demetris AJ, Thomson AW, Geller DA: J Immunol. 2015 Jun 15;194(12):6045-56. doi: 10.4049/jimmunol.1402505. Epub 2015 May 11.